Abstract:An innovative approach is required for making a useful advance in the field of low power tampering detection and reverse engineering technologies. Our team's proposal is to investigate and test such an approach, utilizing near-field transduction and plasmonic components. Advantages of this… more
Abstract:The technical objectives of this proposal are: 1) the design of 3.8-4.2 micron-emitting, active-photonic-crystal (APC) quantum-cascade (QC) lasers by using passive phase-locking in a monolithic structure in order to achieve multiwatt-range, diffraction-limited powers; and 2) the development of the… more
Abstract:DESCRIPTION (provided by applicant): Our long term goal is to widespread the use of PPF technology for promoting effective production of drug-encapsulating microparticles with uniform size and physical characteristics that can be leveraged to release a specific drug at controlled rates over… more
Abstract:Currently, wide area coverage with manned aircraft, or existing unmanned air systems, requires expensive logistical operations and many flight sorties, which are made especially difficult if operating from remote airfields in inhospitable climates. There is currently a need for a low-altitude long… more
Abstract:The innovation proposed for research, and evaluation, and maturation is that of a new class of small Unmanned Air Systems (UAS) with increased payload capability, which may be well suited for use as an aerial payload platform in harsh, remote environments. In specific, the innovation proposed is the… more
Abstract:DESCRIPTION (provided by applicant): The overall goal of this application is to develop a quantitative in-vivo small animal imaging system for fluorescent reporter probes that fuses fluorescence light emitting computed tomography (FLECT) with X- ray computed tomography (CT). The proposed… more
Abstract:The function of many cancer related proteins is modulated by modifications such as phosphorylation and glycosylation. The development of antibodies that recognize site-specific phosphorylation has vastly improved our understanding of signal transductionand cancer cell physiology and regulation.… more
Abstract:DESCRIPTION (provided by applicant): The fragility of osteoporotic bones is largely due to alterations in the underlying structural geometry. Research has demonstrated that it is possible to measure the mechanical geometry of human bones in vivo using dualenergy x-ray absorptiometry (DXA) scans.… more
Abstract:The proposed project builds upon the work done in Phase I with the development of a C-SiC CMC honeycomb material that was successfully tested for mechanical properties at both ambient and high temperature. The further study expands to include the development of an SiC-SiC honeycomb using the proven… more
Abstract:DESCRIPTION (provided by applicant): Advances in protein and DNA microarrays have enabled dramatic increases in throughput and equipment standardization has made these techniques more commonplace. High density, high throughput microarrays reduce the cost of research and development in drug discovery… more
Abstract:DESCRIPTION (provided by applicant): Cryo electron microscopy is a powerful technique for generating 3-D images of macromolecules and their interactions with fine structure within cells. These materials are imbedded in their native state within a thin layer of amorphous ice for imaging in a… more
Abstract:The Project Objective is to achieve a piezoelectric energy harvesting device based on nanotechnology-enhanced materials. The power density is expected to achieve ~1-10 mW per cubic mm and are compatible with Army applications in the field to power autonomous miniaturized sensors. The novelty… more
Abstract:The proposed research effort will develop a highly efficient MEMS energy harvesters that utilize a novel nanocomposite technology recently developed by HARP Engineering LLC. Unlike existing piezoelectric nanocomposites, the material proposed here has an electromechanical coupling coefficient higher… more
Abstract:The objective of this SBIR research project is to develop a treatment for interlaminar reinforcement that maintains the composite"s in-plane properties. Because the interlaminar region is a critical component of the composite and no current technology adequately addresses its weaknesses, this… more
Abstract:Wavelength-division multiplexing has been employed to great success in long-haul transmission systems to increase capacity and provide a new means (wavelength) of routing. Their application to local-area networks (LANs) on aircraft is promising due to the light weight and narrow cross section of… more
Abstract:Fiber-optic gyroscopes (FOGs) are used as the fundamental building block for high-precision inertial and angular displacement sensors in applications ranging from missile and UAV to war-plane and satellite navigation. The nonlinearity-induced non-reciprocity in FOGs is recognized as the critical… more
Abstract:Rapid tuning of narrowband sources is inherently limited by the number of roundtrips required in the high-Q cavity, which is required for generation of a narrow lasing linewidth. We propose to break the cavity tuning/linewidth barrier presented by conventional reconfiguration of the physical cavity… more
Abstract:DESCRIPTION (provided by applicant): The overall goal of this proposal is to develop and commercialize a novel biologic therapy for the treatment of allergic disease and particularly allergic asthma. Specifically, this proposal will provide the critical immunogenicity, mechanistic and biomarker data… more
Abstract:Lightweight robotic excavators address the need for machines that dig,collect, transport and dump lunar soil. Robust and productive smallrobots enable mining rich and accessible deposits of ice and othervolatiles buried near craters at the lunar poles, delivering resources toproduce propellant, and… more
Abstract:A scalable gravity offload device simulates reduced gravity for the testing of various surface system elements such as mobile robots, excavators, habitats, and deployables in a relevant environment. The device is capable of simulating reduced gravity over an arbitrary terrain including such… more
Abstract:DESCRIPTION (provided by applicant): We propose a novel technique to identify and capture circulating tumor cells (CTCs) using engineered adenoviruses and sophisticated flow cytometry. Current techniques for detection of CTCs include reverse transcriptase-polymerase chain reaction (RT-PCR), flow… more
Abstract:DESCRIPTION (provided by applicant): Lab-on-a-chip flow cytometer using color-space-time (CoST) coding method NanoSort, LLC RESEARCH and RELATED Other Project Information 7. PROJECT SUMMARY Fluorescence-activated-cell-sorting (FACS) or flow cytometry enables clinicians and researchers to… more
Abstract:This Phase I, SBIR contract is for the development of a customized lab-on-a-chip fluorescense activated cell sorter (FACS) system that will provide on-chip antibody labeling, enumeration, and sorting of CTCs suitable for downstream molecular analysis. Theaim is to further understand cancer biology… more
Abstract:Mars Sample Return poses some of the most challenging operational activities of any NASA deep space mission. Rendezvous of a vehicle with a sample canister in order to return the canister to Earth requires a variety of complex mathematical processing on a changing data set, coupled with the need to… more
Abstract:DESCRIPTION (provided by applicant): This project will develop a dynamic quantitative phase-imaging interference 4D microscope system to enable creating phase image movies and quantifying motion of live cells and cellular processes in vitro using harmlesslight levels without the need for adding… more
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