Abstract:This Small Business Innovation Research (SBIR) Phase I project focuses on the design of a robust and low-cost enzyme immobilization system to increase the cost-competitiveness of bio-catalytic processes. The lack of a universal, sound, and affordable enzyme immobilization technique has been a large… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project focuses on the development of a high-yield fermentation route for the production of levulinic acid (LA). LA is one of the best-suited C5 building blocks for bio-refinery production due to higher value, broad applications, and likely… more
Abstract:This Small Business Innovation Research Phase II project proposes to develop a novel ablation balloon catheter to perform radiofrequency ablation on atrial fibrillation patients. The intellectual merit of this project is in its use of an innovative approach to positioning, mapping, and ablation for… more
Abstract:This Small Business Innovation Research Phase I project will develop the technology needed for high performance neutron detectors that use Ce3+ activated 6Li glass in the form of monodisperse microspheres with strategically controlled dimensions and architecture. Current Ce3+/6Li glass scintillator… more
Abstract:Today's riverine forces employ combatant patrol/assault craft that relies on speed, acceleration, and maneuverability for survivability and multi-mission success. These capabilities are at risk because of the increasing demand to carry more extensive payloads. Current diesel propulsion systems… more
Abstract:The proposed fiber optic based array shape measurement system functions by measuring the strains of the array hose through the use of embedded fiber optic sensors. The fiber optic sensors respond to deflections (shape changes) of the array hose and these readings are processed by proprietary… more
Abstract:Currently, there are no robust software platforms available for developing and evaluating reusable, virtual, communicative spatio-temporal agents. This makes rapid development and meaningful comparative evaluation, critical requirements for military and non-military applications, infeasible. To meet… more
Abstract:This Small Business Innovation Research Phase II project aims to improve data mining technologies for location analytics. This project will focus on the analysis of semi-continuous GPS and/or WiFi-based location data generated by consumer mobile devices. The anticipated improvements would allow… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project will develop software to automatically detect a broad spectrum of websites that are fraudulent or otherwise harmful to consumers. Much work has been done on specific software capable of detecting websites hosting malware or engaged in… more
Abstract:In the proposed effort, SK Infrared LLC (SKI), a spin-off from the Krishna INfrared Detector (KIND) laboratory at the University of New Mexico (www.chtm.unm.edu/kind), in collaboration with Raytheon Vision Systems (RVS) and Intelligent Epitaxy Inc (Intelliepi) is proposing a systematic study with… more
Abstract:In the proposed effort, SK Infrared LLC, a spin-off from the Krishna INfrared Detector (KIND) laboratory at the University of New Mexico (www.chtm.unm.edu/kind), in collaboration with Raytheon Vision Systems (RVS) is proposing to develop a dual band based imager using a novel unipolar… more
Abstract:The objective of this Phase II research project is to develop a process and associated tools to generate wiring test diagrams automatically using data compliant with the IEEE Automatic Test Markup Language (ATML) family of standards. Test diagrams show the routing of signals from instruments to Unit… more
Abstract:When the stable samarium-152 (Sm-152) isotope is irradiated, radioactive samarium-153 (Sm-153) is produced through a neutron capture reaction in yields of only about 2%, and this radioactive, therapeutic isotope (Sm-153) cannot be separated from the much more abundant (~98%) non-radioactive isotope… more
Abstract:DESCRIPTION (provided by applicant): Tremendous advances in genomics during the past two decades hold great potential for the development of new health innovations. For this potential to be realized in the form of advances in biomedical research and novelprevention, diagnosis, treatment and disease… more
Abstract:DESCRIPTION (provided by applicant): Drug developers desperately need better tools in the laboratory to improve the 90% failure rate of drugs in clinical trials. Liver toxicity is still the leading cause of drug failure, despite extensive preclinical testing in surrogate animal species. HemoShear… more
Abstract:DESCRIPTION (provided by applicant): The frequent inability of in vitro assays and animal models to accurately predict human response to a new drug candidate results in costly drug development failures. HemoShear has developed a platform technology for biodiscovery and drug pharmacology screening… more
Abstract:DESCRIPTION (provided by applicant): A novel approach to discover selective small molecule inhibitors of FABP4 and FABP5 for the treatment of metabolic diseases The Western diet and lifestyle has brought an epidemic of health problems collectively referredto as metabolic syndrome. Obesity plays a… more
Abstract:DESCRIPTION (provided by applicant): Despite the availability of a safe and effective prophylactic vaccine for hepatitis B virus (HBV), each year a significant number of new infections are reported to the CDC in the United States. Worldwide more than 2 billion people have been infected with HBV,… more
Abstract:DESCRIPTION (provided by applicant): Introduction of small interfering RNAs (siRNAs) into cells with transfection reagents results in potent and specific gene silencing by RNA interference (RNAi). Unfortunately, while siRNA-based drugs represent a potentially significant therapeutic paradigm, the… more
Abstract:DESCRIPTION (provided by applicant): Project Summary / Abstract Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting motor neurons in the central nervous system. Degeneration of the motor neurons results in paralysis and eventual death, usually due to… more
Abstract:DESCRIPTION (provided by applicant): This Phase 1 SBIR will develop a non-invasive alternative to radionuclide shunt patency testing for evaluating Normal Pressure Hydrocephalus (NPH) patients with suspected shunt malfunction. Hydrocephalus is a disorder of cerebrospinal fluid dynamics that is… more
Abstract:DESCRIPTION (provided by applicant): This Phase 1 SBIR will develop Continuous Real Time (CRT) ShuntCheck, the first portable, non- invasive device for real time, continuous monitoring of flow in CSF shunts. This device will result in improved clinicalmanagement of hydrocephalus by providing a… more
Abstract:DESCRIPTION (provided by applicant): This Phase 2 SBIR will provide and clinically validate the first portable, non-invasive diagnostic test for differentiating intermittently flowing patent shunts from occluded or partially occluded shunts - ShuntCheck- Micro-Pumper. This device will result in… more
Abstract:Purpose: In prior research, prosocial behaviors in grade school have been correlated with later academic achievement while anti-social behaviors have been associated with later poor academic achievement and deviance. To help teachers monitor students' social behavior, this project will develop a… more
Abstract:Purpose: Prior research indicates that reading difficulties in childhood become more problematic as students move to middle and high school where increasingly challenging material must be learned. Although some older students still struggle with decoding, many more have difficulty constructing… more
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