Abstract:DESCRIPTION (provided by applicant): The primary objective of this Phase I proposal is to develop and evaluate a novel, brain-based and web-deliverable multimedia training program targeting the treatment of social cognition deficits in schizophrenia. Social cognition impairments have been directly… more
Abstract:DESCRIPTION (provided by applicant): The primary objective of this Phase I application is to develop and deploy a novel, neuroplasticity- based, computerized training program that has been shown to drive positive changes in attention, working memory and executive function in a vulnerable aging… more
Abstract:DESCRIPTION (provided by applicant): In comparison to standard x-ray therapy, proton therapy allows an increased dose of radiation to a tumor and by reducing the amount of radiation to healthy tissue. As a result, it provides the best possible option for using radiation to control and eliminate… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will develop an accurate, noninvasive, and cost-effective system for diagnosing and evaluating the severity of neuromuscular diseases. Millions of people in the US suffer from neuromuscular disorders, from generalized diseases like… more
Abstract:DESCRIPTION (provided by applicant): Our goal is to provide neurologists and other clinicians a method for the rapid, painless, non-invasive evaluation of children with neuromuscular disease. Pediatric neuromuscular disorders include muscular dystrophies, spinal muscular atrophy, and… more
Abstract:DESCRIPTION (provided by applicant): Fast Track SBIR Phase I and Phase II Exposure to centrally acting military nerve agents and organophosphorus (OP) pesticides are known to cause death and neurological damage (Coupland 2005, Karalliedee 1989, Buckley 2004). Improved countermeasures to intoxication… more
Abstract:DESCRIPTION (provided by applicant): People with intellectual disabilities (ID) have rates of obesity greater than the general population. They often have poor energy dense diets and tend to be inactive. This group also experiences a high prevalence of health related problems: cancer, diabetes,… more
Abstract:DESCRIPTION (provided by applicant): PSMA is an important biomarker for prostate cancer prognosis and an appropriate target for therapy due to its restricted expression mainly on late-stage, androgen-independent and metastatic prostate cancer cells. Whilecurrently there is only one clinical PSMA… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to develop thin-film high-temperature superconductors (HTS) with superior properties that do not degrade in high magnetic fields for applications as high-performance sensor coils in Magnetic Resonance Imaging (MRI). The… more
Abstract:ABSTRACT: Mycotoxins are a class of weaponizable toxic secondary metabolites of molds and fungi. No treatments exist for exposure to these lipophilic poisons. AuraSense proposes to use lipid and protein modified gold nanoparticles to develop constructs for the sequestration of toxic lipophilic… more
Abstract:ABSTRACT: Polyvalent nanoparticle constructs have unique properties that make them ideal for gene regulation applications, while overcoming many of the challenges which have prevented oligonucleotides from being developed into viable therapies. Specifically, AuraSense is developing constructs… more
Abstract:Project Abstract This Small Business Innovation Research Phase I project proposes to develop low power consumption bistable liquid crystal display (LCD) with capability of color and video display based on micro-engineered surface alignment (MESA) technology, for application of e-book/e-paper and… more
Abstract:The national demand for energy and need for economic development has been driving efforts to create a domestic biofuels industry. Significant investment by both the public and private sectors have resulted in progress but recent government rule making has set ambitious requirements for renewable… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to demonstrate 10% energy conversion efficiency for Organic Photovoltaics (OPVs) through the design and synthesis of new acceptor materials. Polymer-based OPV technology is ideal for clean and affordable energy generation because of… more
Abstract:Solar cells based on organic materials, also called organic photovoltaic cells (OPVs), have attracted broad research interest due to their low-cost, flexibility and light weight. However, OPV technology remains in pre-commercial stage primarily due to the lack of manufacturing process. Despite a lot… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will be used to optimize biofuel production. The fermentation of biofuel ethanol is frequently disrupted by the growth of competing lactic acid bacteria (LAB). LAB compete for the feedstock, produce undesirable acids and inhibit… more
Abstract:DESCRIPTION (provided by applicant): Dramatic growth of the senior population in the U.S. is widely expected to challenge the capacity of this segment of the U.S. health system. Alternative strategies to support seniors living independently will be critical in meeting the short fall. My Health Care… more
Abstract:$14.8 billion of foodservice disposables and packaging (plates, utensils, take out containers, meat trays, bowls etc.) are purchased each year in USA (Freedonia 2009). They are mostly made from Styrofoam/plastics and cause pollution and toxicity in production, usage and disposal. Cities and… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project will design, build, test, and validate a fully operational prototype disk drive incorporating a commutational ramp load actuator (CRLA). The CRLA is a unique and transformative actuator for disk drives that provides significant… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project will develop a fully functional prototype of an accelerometer-based wireless Weigh In Motion (WIM) station. The WIM system will comprise an array of battery-powered 3? cubes, embedded in the pavement, each consisting of an accelerometer… more
Abstract:The evolving understanding of cancer indicates every tumor has distinct characteristics driven by the molecular pathology of the disease. Predicted by this heterogeneity, targeted therapeutic agents are much more successful than a one size fits all approach. Currently, there are no tools to… more
Abstract:Improvement of treatment outcomes for patients with solid tissue tumors depends on the drug s ability to target the genetic mutations responsible for tumor growth. Currently, mutational analysis requires an invasive tissue biopsy, which is clinically impractical to perform repeatedly. Alternatively,… more
Abstract:Biogas & Electric LLC proposes a novel low cost approach to NOx and SO2 removal through a combination of extended absorption and selective non-catalytic reduction. If efficacy in the proposed NOx removal process can be shown, the new method will be adopted by all proposed manure based anaerobic… more
Abstract:This Phase II research expands Phase I research on Saccharina latissima and is to design and develop “seed” nursery methodologies for the development of commercial-scale production of juvenile kelp plants including Alaria esculenta and Laminaria digitata.
The project objectives include:
Abstract:There is worldwide interest in the commercialization of energy efficient, environmentally friendly, hydrogen fuel cell powered vehicles and devices. One of the key challenges in transitioning fuel cell technology to the marketplace is the development of suitable onboard hydrogen storage solutions.… more
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