Abstract:DESCRIPTION (provided by applicant): Deep Brain Stimulation (DBS) devices - 'brain pacemakers' - have emerged as a revolutionary new approach to the treatment of neurological disorders. DBS therapy uses controllable electrical stimulation delivered to specific deep brain structures through… more
Abstract:DESCRIPTION (provided by applicant): Cerebral ischemia is a major cause of death and long-term disability, with high accompanying social and medical costs. Approximately 795,000 Americans suffer a stroke each year at an estimated annual cost of 73.7B (American Heart Association. Heart Disease and… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will undertake engineering Escherichia coli to "breathe" (respire) using an electrode instead of oxygen. An increasing number of industrial bioprocesses use engineered E. coli strains for the production of fuels and chemicals… more
Abstract:DESCRIPTION (provided by applicant): Monoclonal antibodies (mAbs) hold great promise in human health with applications ranging from therapeutic agents that target cancer cells, to diagnostic biomarkers that can detect trace levels of a given antigen. Thispromise is best reflected in global sales of… more
Abstract:DESCRIPTION (provided by applicant): Epigenomics studies represent the next wave of efforts to decode the information embedded in genomes beyond the nucleotide sequences. Dynamic epigenomic changes, such as DNA methylation are key processes in cell differentiation, development and many pathological… more
Abstract:DESCRIPTION (provided by applicant): Developmental delays are common in early childhood, affecting at least 10 percent of children and are markers for later developmental conditions. It is well established that the tremendous adaptability of the brain in the first three years of life means that… more
Abstract:PHASE II TECHNICAL OBJECTIVE
The major objective of this Phase II proposal is to establish open source traffic simulation model and software, and to develop application programming interfaces to accommodate future traffic research needs. Objectives will be accomplished by building and demonstrating… more
Abstract:There is a growing need for new SPM techniques that provide additional information about the sample with higher data rates. In microwave harmonic scanning tunneling microscopy (MHSTM) a microwave signal is coupled to the STM, and several harmonics that are generated by the nonlinearity of the… more
Abstract:In this Phase II SBIR project, NexTech Materials will continue development of high power density solid oxide fuel cell power systems for ship-service applications. The system being developed is based on planar stacks of NexTech"s proprietary FlexCells, which offer unprecedented sulfur tolerance… more
Abstract:Demand for fuel-efficient and reliable electrical power is escalating within the U.S. military. Fuel cells, which provide compact, efficient and energy-dense power, could find immediate application as portable battery chargers, auxiliary power units for silent-watch missions, and primary power for… more
Abstract:Significant resources are required to ensure proper self-localization of submersibles without available reference signals such as GPS or LBL. This is compounded, when the vehicle remains submerged for extended periods of time which is often required for reconnaissance missions. In the case of a… more
Abstract:The goal of the proposed research is the development of a radiation-hardened gyro that reduces SWaP (size, weight, and power) and cost and demonstrates improved performance of ascent phase intercepts. During this effort, NextGen and Gray Research (formerly GH Systems, Inc.) in partnership with RMS… more
Abstract:The ultimate goal of the proposed research is the development of radiation-hardened damage-resistant self-healing synergistic interceptor or Kill Vehicle (KV). The synergistic structure will be made multifunctional by moving the Guidance System (GS) electronics and the missile harness-fairing… more
Abstract:NextGen Aeronautics has teamed with Dr. Diann Brei and Dr. Jon Luntz of University of Michigan for this proposal entitled"Smart Latching Attachment Surface (SLAS),"in response to SBIR Solicitation No. AF103-003. The University of Michigan team has over twelve years of pioneering research… more
Abstract:Leveraging the team"s expertise in conformal load-bearing antenna structures (CLAS) technology, nano-materials, and CNT fabrication, the overall objective of our program effort is to develop CLAS antenna designs with CNT antenna elements which demonstrate significantly improved system level… more
Abstract:Significant resources are required to ensure precision of flight control laws over the large flight envelope of modern aircraft. This is often compounded, when vehicle parameters change due to payload modifications, system upgrades, and degradation or failure of actuation systems. In the case of a… more
Abstract:NextGen Aeronautics Inc. has teamed with San Diego State University build on their successful Phase I effort to develop omni-directioinal antennas that perform independent of their mounting location. The planned work builds upon the team"s extensive prior experience in conformal load-bearing… more
Abstract:Under this Phase II SBIR program NextGen Aeronautics, Inc. in collaboration with Purdue University is proposing to develop and test nanoparticle enhanced high energy density propellants for guns. Our approach consists of a combination of experimental investigations and computational… more
Abstract:The main goal of this proposal is to develop novel lightweight high strength composite materials to be used as materials for next-generation transparent armor for multifunctional structural load support and mitigation of ballistic threats and blast impacts. While providing adequate protection most… more
Abstract:Superhydrophobic nanostructured coating will be developed from transparent ultrastrong materials. The coatings will be scalable, inexpensive, mechanically robust and thermally resilient. We will initially design such coatings using layered nanocomposites. Then it will be optimized for different… more
Abstract:Superconducting radio frequency (SRF) accelerating cavities are being successfully used for acceleration of electron beams worldwide. The use of superconducting structures helps maximize the accelerating gradient, which is a highly desirable trait for applications involving linear accelerators or… more
Abstract:in accelerators for light sources, first as passive cavities for stabilizing the beam and later in the accelerating sections. In this SBIR proposal, Niowave and Brookhaven National Lab will collaborate to adapt the quarter wave cavity geometry for use as an accelerating structure for light sources.… more
Abstract:The highest priority in the Nuclear Physics program is, at present, the Facility for Rare Isotope Beams. In the longer term it is likely that a high priority will be an Electron Ion Collider, and several concepts are under development. In order to achieve the high luminosities that would be required… more
Abstract:Recent advances in superconducting electron linacs have decreased the size and complexity of these systems such that they can be economically competitive with copper linacs and proton accelerators for a broad range of applications. Niowave is developing compact turn-key superconducting electron… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will result in developing novel high-power, high-efficiency Deep Ultraviolet Light Emitting Diode (DUV LED) Lamps based on an innovative and new micro-pixel device design. Deep ultraviolet light sources with emission wavelengths lambda… more
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