Abstract:The quest for deepened understanding of the origin of the universe requires continued search for elementary particles, for which high-energy accelerators are necessary tools. Reducing the size, complexity, and cost for future accelerators is essential if they are ever to be built. New technologies… more
Abstract:In a two-beam accelerator, a high-current drive beam imparts energy to a low current test beam by generating microwave power that flows from one beam to the other. The largest project of this sort is CLIC, located at CERN in Geneva, Switzerland, that is being designed for operation at an… more
Abstract:Thermionic cathodes are in use in an overwhelming majority of vacuum electronics devices, including high-power RF sources used to drive particle accelerators. These cathodes do not operate reliably or have long lifetime if their current density exceeds 5-10 Amperes/cm2. Artificial diamond and… more
Abstract:Invasive, metastatic, and/or drug resistant cancers are responsible for most cancer deaths. Development of a drug that blocks these phenotypes to improve outcomes is the ultimate objective. The specific means is by inhibiting the acidification of extra-cellular and extra-tumoral environments that… more
Abstract:ABSTRACT: New energetic materials are needed for use in explosives and propellants that have a very powerful energy release yet are insensitive to handling. Safer materials that also allow development of lighter weight, longer range missiles and higher performance explosives are needed. One class… more
Abstract:Fixed and rotary winged aircraft require directed infrared counter-measures (DIRCM) systems to self-protect against heat seeking missiles, and the DIRCM multi-spectral light source is a key enabling technology and differentiator. Omni Sciences, Inc. (OSI), has developed a Mid-Infrared… more
Abstract:Mandates for biofuels have resulted in the significant increase of biodiesel production in rural communities. Hawaii's Jatropha biodiesel production will produce nearly 650-700 kg of residues, consisting of Jatropha seedcake and fruit hulls for every metric ton of seeds harvested for oil… more
Abstract:The primary objective of this project is to develop of several novel classes of inertia devices such as accelerometers for use for flight control in high-G gun-fired munitions and mortars. The proposed accelerometer concepts are intended to provide high sensitivity of better than 0.05 G while being… more
Abstract:DESCRIPTION (provided by applicant): The recent success of imatinib for the treatment of Philadelphia chromosome-positive chronic myelogenous leukemia has made tyrosine and serine/threonine kinases as major targets for cancer therapy. Currently, since only a small fraction of the human kinome has… more
Abstract:The overall goal of this proposed program (through Phase III) is to develop a chemical warfare agent analyzer capable of detecting vapor phase agents at 10-7g/m3 in less than 1 minute. This will be accomplished by developing a method to produce novel localized surface plasmon resonance (LSPR)… more
Abstract:The overall goal of this proposed program (through Phase III) is to develop a chip-scale assay that can detect, identify, and quantify the presence of Category A (or B) bioagents in water at the required sensitivity (e.g. 8000 B. anthracis spores or 50µg of ricin per liter water) within 10 minutes.… more
Abstract:The goal of this Phase II program is to bring the Marine Corps (RTA) Fuel Analyzer to a readiness level sufficient for production. This will accomplished by building three test units to establish temperature use range and validate fuel property analysis.
Abstract:Web based training has matured into fully immersive, interactive scenarios that enhance the student"s retention of critical study information through experience based simulation. Creation and use of web based Serious Games can be quite complicated, depen
Abstract:Ontar"s technical objective for this program is to develop a hardware and software solution for both understanding of and augmentation of cognitive readiness at both the individual and command levels. During Phase I we will define the following features and capabilities: Develop a detailed… more
Abstract:Advanced recycling of lithium-ion battery materials has potential to significantly reduce material costs. Current recycling technology is expensive and melts or dissolves batteries for valuable elements, leaving no potential for direct secondary material use for battery applications. These old… more
Abstract:The Phase I effort aims to demonstrate a new approach to coilable crystalline fiber lasers that builds on Onyx Optics"experience of manufacturing adhesive-free composite waveguide structures to produce bendable double-core laser ribbons. Onyx Optics proposes to focus on the manufacturing and… more
Abstract:"Operational Technology Corporation (OpTech) proposes to couple the ultrasensitivity of fluorescence-based detection with the high selectivity of synthetic DNA aptamers as replacements for antibodies to detect chemical and biological (CB) terrorism threats in 10 minutes or less from a variety of… more
Abstract:Operational Technologies Corporation (OpTech) has completed a successful Phase I SBIR contract in which 72 new candidate DNA aptamer sequences against Leishmania major were developed and screened by ELISA-like plate assay. Several pilot assays were developed from the highest affinity candidate… more
Abstract:Operational Technologies Corporation (OpTech) has completed a successful Phase I SBIR contract in which 124 new candidate DNA aptamer sequences against five different species of rickettsiae were developed and screened by ELISA-like plate assay. Several pi
Abstract:DESCRIPTION (provided by applicant): The proposed project details a biologic strategy for the therapeutic targeting of nicotinic receptors of the cholinergic system for the treatment of mental and neurological disorders. The cholinergic system is an important modulatory neurotransmitter system,… more
Abstract:DESCRIPTION (provided by applicant): Nicotine is one of the most heavily used addictive drugs and accounts for 90% of lung cancer cases in the U.S. Recent studies have implicated a specialized receptor class binding to nicotine, the CHRNA5 gene, which encodes the a5 subunit of the nicotinic receptor… more
Abstract:Ophir proposes to develop a multifunction, low-cost lidar capable of accurately measuring kinetic air hazards, and air data, simultaneously. The innovation is providing a single sensor that has dual-use functionalityÂ? air data measurement and kinetic air hazard detection in a package that is… more
Abstract:DESCRIPTION (provided by applicant): Mass spectrometry has become an important tool for understanding how molecules function in sample systems such as biological tissue. Large RandD investments have been dedicated to the technological progress of mass spectrometers. To add value to these investments… more
Abstract:ABSTRACT: Opteos Inc. is proposing a new approach to the measurement of electric fields based on the electrooptics principles. This system promises an extremely high bandwidth of operation, 50GHz to 100GHz, a wide dynamic range up to 60dB, and high accuracy better than 1% full scale. The system is… more
Abstract:Optical Physics Company is proposing to implement an interferometric angle sensor for the purpose of determining the relative angle between the two diffracting crystals. Two approaches can be pursued, namely (1) the dual grating interferometer, and (2) the angle interferometer. The estimated cost of… more
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