Abstract:DESCRIPTION (provided by applicant): This is a Phase II proposal to advance development of disubstituted tetrahydro-triazolo-pyrimidines (TTPs) as specific inhibitors of hepatitis B virus surface antigen (HBsAg) secretion in chronic infection. High serum levels of HBsAg (antigenemia) are believed to… more
Abstract:DESCRIPTION (provided by applicant): PharmacoPhotonics (DBA FAST, Inc.) proposes Fast-Track research to determine GFR in its first human Pilot study. The long-term goal of this SBIR project is to test FAST's minimally invasive catheter based fluorescent device in humans and commercialize this… more
Abstract:DESCRIPTION (provided by applicant): Despite the success of TNF-inhibitors and other new biological drugs for the treatment of autoimmune and other chronic inflammatory diseases, there are still many patients that respond poorly. Suppressing NF-kB induction as treatment of chronic inflammatory… more
Abstract:DESCRIPTION (provided by applicant): The purpose of the present project is to demonstrate the feasibility of using a novel RFID chip to tag and track tissue cassettes and glass slides that are used in histopathology laboratories. The system is based on thePharmaSeq laser light-activated… more
Abstract:PhaseSpace and the University of Southern California (USC) propose a hybrid tracking solution that will combine the PhaseSpace Impulse LED tracking technology with computer vision image processing and inertial tracking. The hybrid tracker will track IR LEDs on a soldier''s head, fingers,… more
Abstract:For this Phase 2 effort related to STTR Topic N09-T031, PhaseSpace proposes building an HMD system using pico-projectors and reflective transparent lenses. The system will be low-cost, but the improved field-of-view (improved compared to current state-of-the-art) will provide a higher quality… more
Abstract:Difficulties associated with thick lithium-diffused entrance windows on the outside of p-type coaxial and point-contact germanium gamma-ray detectors have always been a technical hindrance. The lithium dead layer limits the low-energy detection range and adds background in the energy spectrum,… more
Abstract:DOE Nuclear Physics user facilities require larger high-resolution gamma-ray detector systems to provide higher sensitivity measurements. Large diameter germanium crystals are being grown, evaluated, and iteratively improved in the laboratory. Large-diameter crystals will be made into large… more
Abstract:We propose a metamaterial-enhanced microbolometer with strong absorption over a narrow band that is dynamically tunable over the 8-10 micron band. A single-layer photonic metamaterial consisting of a thin metal film perforated with a 2-D array of dielectric apertures will be deposited on an… more
Abstract:The objective of proposed Phase II project is to develop multi-junction Graetzel cells using a cost effective, single layer metamaterial light harvesting template into which, up to four different sets of wavelength-selective ruthenium dye complexes are deposited. The light harvesting template… more
Abstract:Successes to date with the use of integrated software framework tools have led NASA engineers and other researchers to expand the breadth, depth, and sophistication of the problems that they are attempting to solve. Both the utilization of "high-fidelity" physics based models… more
Abstract:In the defense industry today, high level SysML system models are used by engineers beginning early in the design process to functionally decompose the system being designed and to flow down requirements to sub-systems and components. Despite their usefulness, these system models are by and large… more
Abstract:This proposed work is to advance the Electric Sparker Impulsive Source (ESIS) sonobuoy and its specialized parts technology into a sonobuoy. This includes developing a new low cost high voltage switch and converting the packaging to meet A-size sonobuoy air-droppable form factor requirements. ESIS… more
Abstract:DESCRIPTION (provided by applicant): A new class of high-performance X-ray phosphor screens will be developed based on dot-in-a-rod core/shell nanorod (NR) structures embedded in transparent polymer matrices, with applications to protein crystallography, digital radiography and mammography, as well… more
Abstract:This Phase I SBIR proposal is submitted to address the needs of researchers needing high power narrow spectral linewidth diode laser pump sources for alkali vapor lasers. Diode-pumped alkali vapor lasers (DPALs) can be most efficiently pumped with spectrally-stabilized laser diode arrays (LDAs)… more
Abstract:This proposal addresses the need to increase the probability of detection (PD) and reduce the probability of false alarm (Pfa) for non-contact, real-time sensors for trace levels of biological and chemical targets using simultaneous detection of Raman and fluorescence emissions. Raman… more
Abstract:Users of phased arrays with large numbers of elements (e.g., 40,000 to 400,000) wish to have the capability of steering multiple beams simultaneously and to maximize the array bandwidth and dynamic range. Optical fiber"s light weight, small size, and immunity to electromagnetic interference… more
Abstract:The company proposes to offer a sensor-software solution to advance the Air Force goal of robust, long-term identity, tracking and behavior awareness by using patented Spatial Phase Imaging (SPI) technology. With the capabilities of this technology, it will be possible to simultaneously obtain… more
Abstract:Under a recently completed Air Force SBIR Phase II program, we demonstrated the initial feasibility of a back-illuminated p-on-n LWIR HgCdTe junction photodiode formed by diffusion of arsenic from a vapor source. This initial successful demonstration used a mesa format. Our proposed Phase I… more
Abstract:DESCRIPTION (provided by applicant): The long-term goal of this project is to develop Poloxamer-188 (P-188) for the delay or prevention of respiratory deficits in patients with Duchenne muscular dystrophy (DMD). Phrixus Pharmaceuticals Inc. is also developing P-188 for the treatment of acute… more
Abstract:DESCRIPTION (provided by applicant): Although conventional sample handling can be adapted for use with processing zebrafish, development of appropriate analytical tools has not kept pace with the increasing use of this animal model for compound screening.In this research, we propose to develop a… more
Abstract:This proposal aims to develop and demonstrate a novel fused sensor system capable of detecting bullets in real time and over a 360o field-of-view. The bullet detection is based on a retrodirective noise-correlating radar that also provides the bullet bearing in real time. The bearing information… more
Abstract:To address this HSARPA need, Physical Optics Corporation (POC) proposes to develop a new Visor-Enhanced SCBA Transparent
Armor (VESTA) lens, based on a transparent metallic-oxide material system, and serving as a drop-in replacement lens in current
mask systems. VESTA possesses improved… more
Abstract:To address the HSARPA need for a next generation helmet with an embedded heads up display for personal situation awareness for emergency
responders, Physical Optics Corporation, POC, proposes to continue the development of the Helmet Embedded Conformal Augmented Display,
HECAD, system. The HECAD… more
Abstract:DESCRIPTION (provided by applicant): It is widely know that if retinopathy and specifically diabetic retinopathy are not duly detected and controlled through medical interventions, they can progress into a proliferative retinopathy and cause significant decrease in… more
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