Abstract:Sensor protection against agile-frequency lasers is a critical Army Technology Objective (ATO). We propose simple defocusing of existing sensor optics as a layer within the optical limiting (OL) stack. This requires no additional optical components, and promotes compatibility with other OL stack… more
Abstract:DESCRIPTION (provided by applicant): Cerebral edema (CE, or brain swelling) is a major contributor to the damage caused by stroke, traumatic brain injury, and bacterial meningitis. Stroke alone is the third leading cause of death in the USA and the leadingcause of disability. Unfortunately, few… more
Abstract:Electric propulsion (EP) thrusters have the potential to enhance or enable Discovery-class missions. However, a significant challenge in scaling micro (<100 W) EP devices up as well as scaling macro (> 1 kW) EP devices down is the lack of a compatible neutralizer technology in the meso scale… more
Abstract:ABSTRACT: Aerophysics has developed the Local Space Imaging System (LSIS) to provide proximity detection for spacecraft. The LSIS sensor is a small, bolt-on unit that meets many of the requirements for this solicitation: the LSIS is small, low-power, semi-autonomous, and two LSIS units could cover… more
Abstract:Atmospheric aerosols influence the earths radiation balance through direct scattering and absorption of radiation, and through alteration in the formation, brightness and extent of clouds. The concentrations and size distribution of aerosols aloft is important to these effects. Needed is a method to… more
Abstract:Secondary and oxygenated organic compounds play an important role in the atmosphere. These constituents are involved in atmospheric transformation processes, and may play a significant role in the formation of cloud condensation nuclei. Unanswered questions include the relative importance of… more
Abstract:Fast gating or shuttering of light through a large aperture is possible with a HOE (holographic optical element) written into new novel materials such as, but not limited to, EO polymers. These materials can be non-birefringent thin or thick films applied to an optical substrate of a square… more
Abstract:The objective of this research and development effort is to encourage the genesis of innovative, high performance avionics systems, subsystems, and components that will enhance the capability of successfully achieving early intercept missile defense in current and future interceptors in a hostile… more
Abstract:DESCRIPTION (provided by applicant): This application is in response to NIH/PSH 2010-2 'Omnibus solicitation for SBIR/STTR Grant Application' under NIDA 2, Development of Alternate Drug Delivery Dosage Forms for Drugs Abuse Studies . Through the use of tobacco, nicotine is one of the most… more
Abstract:DESCRIPTION (provided by applicant): Development of automated neurobehavioral assay for rodent stroke model assessment Millions of elderly people suffer from stroke, which is the third leading cause of death in the US, after heart disease and cancer. Stroke survivors suffer from motor and cognitive… more
Abstract:Our proposed approach to computer security is proactive. We collect data through a set of sensors which is used to adapt to an attack, while protecting the operational integrity of the system under its protection.
Abstract:DESCRIPTION (provided by applicant): Bone cements are widely used in maxillofacial surgery, repair of cranial defects, and dental fillings. Calcium phosphate bone cements are useful in many types of bone repair because they conform to the defect area, harden in situ, and can be resorbed and replaced… more
Abstract:DESCRIPTION (provided by applicant): Over 700,000 surgical hernia repairs are performed each year in the United States and despite recent advances, a significant rate of recurrence persists. Incisional or visceral hernia repairs account for 100,000 of these surgeries costing 1.7B annually, and have… more
Abstract:DESCRIPTION (provided by applicant): Approximately 500,000 bone-grafting procedures are performed each year in the United States.5 Autologous iliac crest bone graft continues to be the gold standard, because it provides essential elements for bone formation: progenitor cells, an osteoconductive… more
Abstract:DESCRIPTION (provided by applicant): Falls are the leading cause of injury-related visits to U.S. emergency departments and the primary etiology of accidental deaths in persons over the age of 65 years1. Interventions such as physical therapy, adjusting medications, or behavior changes can reduce… more
Abstract:The chloroperoxidase enzyme from the filamentous fungus Caldariomyces fumago has applications in industrial chemical synthesis and the detection and inactivation of chemical warfare agents. Chloroperoxidase is capable of regio- and enantioselective oxygenations and halogenations of organic… more
Abstract:The ability to direct the wound pathways following injury could provide a critical path in wound care at crucial times during the progression of healing. A promising field of study in wound healing is epigenetics; alterations in gene expression caused by mechanisms other than changes in DNA… more
Abstract:Currently, the accepted standard experimental model for measuring protective efficacy against botulism is the Mouse Lethality Neutralization (MLN) assay. Botulism poisoning is a life threatening condition that is not only a public health concern, but could also be a potential biological weapon. … more
Abstract:ABSTRACT: Volatile Organic Compounds (VOCs) serve an important role in manufacturing processes as solvents. However, once these products reach the marketplace the industrial solvents are released into the ambient air, causing them to concentrate in enclosed work spaces such as office buildings.… more
Abstract:Field testing of water samples is needed for broad and sensitive detection of toxic industrial chemicals, or TICs. The use of unicellular organisms in cell-based detection systems is particularly advantageous both because these organisms have developed a natural ability to respond to environmental… more
Abstract:Organophosphorus chemical warfare nerve agents (OP-CWA) are attractive to terrorist groups and rogue states as an inexpensive and accessible technology for chemical warfare. OP-CWA and organophosphate pesticides cause severe neurological symptoms and death by inhibiting the enzyme… more
Abstract:Current toxicity testing of foodstuffs involves mass spectrometry analysis which requires a>24 h turnaround time in deployed military operations. This length of time is dangerous for personnel. Rapid identification of toxic industrial chemicals (TICs) in food using a sensor that is… more
Abstract:ABSTRACT: During the normal course of research, development, and testing by the DOD small quantities of environmentally hazardous waste propellants, explosives, and pyrotechnics (PEP) are produced. The compliance costs and burden associated with open burn/open detonation operations are… more
Abstract:Recent studies have suggested the potential of improved malarial vaccines by use of the viral-like particle (VLP)-linked immunogen approach. The VLP technology is being utilized for the development of vaccines for a variety of diseases. Agave BioSystems is creating a novel platform for development… more
Abstract:Dengue viruses are transmitted by mosquito vectors throughout tropical and subtropical regions of Asia, Africa, and Central and South America. Four serotypes circulate, DEN-1 through -4, and immunity to one type does not preclude illness from another type and can exacerbate subsequent disease with… more
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