Abstract:The proposed application for phase II deals with the prototyping and demonstration of a blackbody laser source of high brightness capable of simulating targets of varying temperature. This will enable a flexible and powerful missile plume simulator that can be used in airborne laser systems for… more
Abstract:During the Phase I SBIR project funded by DLA, Fairmount Technologies (FT) has developed and proven a new CNC metal forming process called stretch roll forming (SRF) that can produce complex parts made out of extrusions without part-specific dies. The proofof- concept machine developed has stretch… more
Abstract:The objective is to develop approaches are sought for sample preservation of nucleic acids from blood products or other sample for storage at room temperature conditions. The goals of the project are to: 1) determine preferable tissue for nucleic acid archiving; 2) investigate sample collection… more
Abstract:Sentien Biotechnologies is developing cellular devices for the treatment of acute organ failure, including polytrauma-induced multiple organ dysfunction syndrome (MODS). Our flagship product, the Sentinel, is a dialyzer with mesenchymal stem cells (MSCs) seeded in the extracapillary space, designed… more
Abstract:DESCRIPTION (provided by applicant): The goal of this Phase I project is to develop a cell-coated device for the treatment of acute liver failure. The device harnesses mesenchymal stem cell secretions to provide combined anti-inflammatory and regenerativesupport. The project specific aims are: (1)… more
Abstract:DESCRIPTION (provided by applicant): Mucopolysaccharidosis type I (MPS I) is an autosomal recessive storage disease caused by the absence of a-L-iduronidase (IDUA), resulting in systemic accumulation of glycosaminoglycan (GAG) storage materials, hepatosplenomegaly, skeletal dysplasias,… more
Abstract:DESCRIPTION (provided by applicant): The overall goal of this project is to develop a novel gene-based delivery system to treat neovascular age- related macular degeneration (wet AMD), a debilitating ocular disease. AMD is the leading cause of blindness inAmericans over 60 years of age, with wet AMD… more
Abstract:DESCRIPTION (provided by applicant): This application is to deliver high-performance, GPU-enabled computation and visualization software tools to neuroscientists. Today, there are an estimated 1.5 million life science MATLAB users, with a substantial portion of those using MATLAB to solve… more
Abstract:DESCRIPTION (provided by applicant): Despite significant advancements in modern medicine with regards to surgery, radiation therapy and imaging of tumors, the survival rate for patients with non-small-cell lung carcinoma (NSCLC) remain almost identical to20 years ago. Current therapies targeting the… more
Abstract:ABSTRACT: This proposal attepts to develop a new high efficiency process for conversion of carbon dioxide and water to syngas, as a first step in production of synthetic fuels. We have already demonstrated the conversion of carbon dioxide to carbon monoxide at over 80% energy efficiency. The… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to develop inexpensive carbon dioxide sensors for heating, ventilation and air conditioning (HVAC) controls. The sensors will use Dioxide Materials' patent pending catalyst mixtures, to create a series of CO2 sensors using a… more
Abstract:DESCRIPTION (provided by applicant): Alzheimer's disease (AD), the most common geriatric dementia, has become a major threat to aging baby boomers and presents one of the leading, long-term economic and health burdens to our society. The estimated cost ofAD in the US for health care and hospice… more
Abstract:We developed a technology called PlatinDx that, based upon preclinical data, can potentially identify chemoresistance in lung and bladder cancer patients before they receive carboplatin therapy. PlatinDx utilizes tracing of subtherapeutic microdoses of14C-labeled carboplatin with accelerator… more
Abstract:A. Background Information We developed a technology called PlatinDx that, based upon preclinical data, can potentially identify chemoresistance in breast cancer patients before they receive oxaliplatin therapy. PlatinDx utilizes tracing of subtherapeuticmicrodoses of 14C-labeled oxaliplatin with… more
Abstract:A series of national innovation reports, surveys, and case studies sponsored by the Council on Competitiveness, University of Southern California Information Sciences Institute, industry groups, and government agencies uncovered inadequate adoption of high performance computing (HPC) technology in… more
Abstract:DESCRIPTION (provided by applicant): The purpose of this Phase II project is to develop a new treatment for pulmonary arterial hypertension (PAH) consisting of the inhaled platelet derived growth factor receptor (PDGFR) inhibitor PK10453. PAH is a diseaseof the pulmonary vasculature associated with… more
Abstract:DESCRIPTION (provided by applicant): The presence of islet-directed auto-immunity and associated circulating auto-antibodies, previously thought to be primarily characteristic of type-1 diabetes mellitus (T1DM), is now apparent in a proportion of individuals with putative type-2 diabetes (T2DM),… more
Abstract:DESCRIPTION (provided by applicant): Craving, when viewed as a compelling desire to consume a potentially harmful substance or to engage in a potentially harmful act, has been increasingly targeted for basic research, clinical assessment, and treatment. The management of cravings is a critical… more
Abstract:DESCRIPTION (provided by applicant): Development of a phase 2 beta for demonstration in Tree Top juice processing plant of a Field Applicable Real-time Remote Monitoring Sensor Device capable of detecting multiple pesticides simultaneously in unfiltered juice, fluid or waste water. We propose to… more
Abstract:According to the American Cancer Society 220,000 men and women in the U.S. develop lung and bronchial cancer every year and 147,000 die of the disease. Of lung cancer patients, 85% present with non-small-cell lung cancer and 16.7% of these will present with localized disease. Note that lung cancer… more
Abstract:DESCRIPTION (provided by applicant): Approximately 25% of the products being developed by the biotechnology industry are antibodies and many of these antibodies are directed to epitopes on human cells and tissues. We are proposing a novel concept for the production of antibodies with therapeutic… more
Abstract:DESCRIPTION (provided by applicant): We seek to capitalize on a substantial body of work has characterized the immune responses of HIV+ individuals with very slow disease progression (LTNP), and HIV- individuals who do not seroconvert despite repeated HIVexposure (ESN). A fraction of people in these… more
Abstract:ABSTRACT: Sapphire possesses a number of physical properties, including high strength, high melting point, chemical inertness, and excellent transparency in the visible and IR spectrum, which make it an attractive window material for military applications. For Phase I, Rubicon Technology… more
Abstract:ABSTRACT: Early spacecraft were very expensive and took many years to painstakingly develop. The high cost and infrequency of space launches fostered a culture of exquisite performance at exquisite prices. With space access and usage becoming more prevalent, the modern metrics of development speed… more
Abstract:ABSTRACT: The main issue with the development of a reliable constitutive model for explosive materials and concretes is the lack of a fundamental understanding of the evolution of 3-D microstructure and damage in these materials when they are subjected to multi-axial loading under confinement… more
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