Abstract:We developed a technology called PlatinDx that, based upon preclinical data, can potentially identify chemoresistance in lung and bladder cancer patients before they receive carboplatin therapy. PlatinDx utilizes tracing of subtherapeutic microdoses of14C-labeled carboplatin with accelerator… more
Abstract:A. Background Information We developed a technology called PlatinDx that, based upon preclinical data, can potentially identify chemoresistance in breast cancer patients before they receive oxaliplatin therapy. PlatinDx utilizes tracing of subtherapeuticmicrodoses of 14C-labeled oxaliplatin with… more
Abstract:A series of national innovation reports, surveys, and case studies sponsored by the Council on Competitiveness, University of Southern California Information Sciences Institute, industry groups, and government agencies uncovered inadequate adoption of high performance computing (HPC) technology in… more
Abstract:DESCRIPTION (provided by applicant): The purpose of this Phase II project is to develop a new treatment for pulmonary arterial hypertension (PAH) consisting of the inhaled platelet derived growth factor receptor (PDGFR) inhibitor PK10453. PAH is a diseaseof the pulmonary vasculature associated with… more
Abstract:DESCRIPTION (provided by applicant): The presence of islet-directed auto-immunity and associated circulating auto-antibodies, previously thought to be primarily characteristic of type-1 diabetes mellitus (T1DM), is now apparent in a proportion of individuals with putative type-2 diabetes (T2DM),… more
Abstract:DESCRIPTION (provided by applicant): Craving, when viewed as a compelling desire to consume a potentially harmful substance or to engage in a potentially harmful act, has been increasingly targeted for basic research, clinical assessment, and treatment. The management of cravings is a critical… more
Abstract:DESCRIPTION (provided by applicant): Dental caries (tooth decay), is the single most common chronic disease of childhood, affecting nearly 6 in 10 children in the United States. Poor oral health is epidemic among all children, but is especially severe among lower income children. Untreated, tooth… more
Abstract:DESCRIPTION (provided by applicant): Quick-Set Material- Phase II Quick-Set material is proposed for vital pulp therapy and for non-vital endodontic use to make the clinical procedures shorter and more consistent, of benefit to the patient and clinician,and enhance the probability for a positive… more
Abstract:DESCRIPTION (provided by applicant): Dental implants have very high survival rates and are the fastest growing field in dentistry. But, high complication rates result in significant morbidit, cost, and disappointment. Better pre-operative knowledge of softtissue thickness and hard tissue contour… more
Abstract:DESCRIPTION (provided by applicant): Development of a phase 2 beta for demonstration in Tree Top juice processing plant of a Field Applicable Real-time Remote Monitoring Sensor Device capable of detecting multiple pesticides simultaneously in unfiltered juice, fluid or waste water. We propose to… more
Abstract:According to the American Cancer Society 220,000 men and women in the U.S. develop lung and bronchial cancer every year and 147,000 die of the disease. Of lung cancer patients, 85% present with non-small-cell lung cancer and 16.7% of these will present with localized disease. Note that lung cancer… more
Abstract:DESCRIPTION (provided by applicant): Approximately 25% of the products being developed by the biotechnology industry are antibodies and many of these antibodies are directed to epitopes on human cells and tissues. We are proposing a novel concept for the production of antibodies with therapeutic… more
Abstract:DESCRIPTION (provided by applicant): We seek to capitalize on a substantial body of work has characterized the immune responses of HIV+ individuals with very slow disease progression (LTNP), and HIV- individuals who do not seroconvert despite repeated HIVexposure (ESN). A fraction of people in these… more
Abstract:ABSTRACT: Sapphire possesses a number of physical properties, including high strength, high melting point, chemical inertness, and excellent transparency in the visible and IR spectrum, which make it an attractive window material for military applications. For Phase I, Rubicon Technology… more
Abstract:ABSTRACT: Early spacecraft were very expensive and took many years to painstakingly develop. The high cost and infrequency of space launches fostered a culture of exquisite performance at exquisite prices. With space access and usage becoming more prevalent, the modern metrics of development speed… more
Abstract:ABSTRACT: The main issue with the development of a reliable constitutive model for explosive materials and concretes is the lack of a fundamental understanding of the evolution of 3-D microstructure and damage in these materials when they are subjected to multi-axial loading under confinement… more
Abstract:The Army has identified the need to enhance existing ground-based surveillance platforms by utilizing polarimetric imaging (PI). Situational awareness imagery has become a vital tool for locating and helping to neutralize roadway threats. The urgency of these threats demands quick, cost effective… more
Abstract:ReliaCoat Technologies, LLC, a Stony Brook University based spin-off, in conjunction with program partner Prof. Nitin Padture of Brown University and collaborators GE Aviation and Sulzer Metco, proposes to develop innovative and cost effective approaches for design and processing of high performance… more
Abstract:ABSTRACT: ReliaCoat Technologies, LLC, a Stony Brook University based spin-off, in conjunction with program collaborators GE Aviation, Sulzer Metco, Argonne National Lab and Stony Brook University, proposes to develop innovative approaches for in-situ measurement methodologies and tools on real… more
Abstract:ABSTRACT: ReliaCoat Technologies, LLC, a Stony Brook University based spin-off, in conjunction with program advisors GE Aviation, Sulzer Metco, Cincinnati Thermal Spray and other spray applicators proposes to design, develop and commercialize an advanced thermal spray process control strategy with… more
Abstract:ABSTRACT: ReliaCoat Technologies, LLC, a new business spin-off from Stony Brook University, together with the University and collaborators (GE, Sulzer Metco, CTS, SWI) proposes to develop and commercialize a novel in-situ coating property (ICP) technology as a real-time coating monitoring sensor,… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to develop specialized materials formulations based on functionalized graphene sheets (FGS) for electrochemical biosensor platforms. While carbon-based electrodes have been applied in a wide range of electrochemical sensor… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project aims to develop high-performance graphene-based conductive inks for printed electronics to meet its stringent cost, flexibility, and conductivity requirements. Components printed with existing conductive inks are challenged by repeated… more
Abstract:Disruptive fibers for flexible armor and related applications require high modulus, tenacity, and thermal/environmental stability. In organic fibers, high stiffness arises from high molecular orientation, often coupled with high crystallinity within the polymer chains. On the other hand, the… more
Abstract:ABSTRACT: The proposed project would design a 10-ton multi-energy source, integrated cooling, heating, and power system, including the solar collectors, with the capacity to produce 8kWe of back-up electrical power. The system is a single integrated cooling, heating and power generation unit. It is… more
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