Abstract:Emergency departments, trauma centers, and military field physicians have a critical need for a simple, easy-to-use, and reliable method of monitoring the onset of hemorrhagic shock that is able to predict onset during the compensatory phase, before syncope and cardiac collapse signaled by a rapid… more
Abstract:Since the launch of the first X-ray focusing telescope in 1963, the development of grazing incidence X-ray optics has been crucial to the development of the field of X-ray astronomy. The recent Decadal Survey also highlights the important contribution that X-ray astronomy can make in addressing… more
Abstract:In this effort, Radiation Monitoring Devices, Inc. (RMD) addresses NASA's request for sensitive, high quantum efficiency (QE) optical detectors for space- and ground-based light detection and ranging (Lidar) instruments. We propose to address this need by utilizing our latest designs in solid… more
Abstract:Gamma ray and neutron spectroscopy are well established techniques for determining the chemical composition of planetary surfaces, and small cosmic bodies such as asteroids and comets; however, new technologies with the potential to significantly improve the performance of planetary nuclear… more
Abstract:DESCRIPTION (provided by applicant): Some of the most useful tools for diagnosis and understanding of blinding retinal diseases rely on the use of spectral reflectance. Improvements to these tools, especially over the past decade, have greatly advanced ourability to achieve extremely high-resolution… more
Abstract:Recent improvements in synchrotron radiation sources have generated an urgent need for high-performance X-ray detectors. While new imaging devices have been developed that employ high-performance CCD sensors, what is currently lacking in these detectors is an adequate X-ray-to-light converter … more
Abstract:X-ray microtomography (XMT) is a powerful tool for researchers in a wide range of fields, enabling 3D imaging at the micron scale. Many of the DOE synchrotron tomography facilities are involved in research that requires hard X-rays (high energy, up to 100 keV) in order to get better penetration… more
Abstract:Advanced sensors and measurement techniques are needed to increase resolution, and sensitivity to defects while reducing the intrusiveness and cost of inspection at nuclear power plants. Zirconium, a metal with a low neutron absorption cross section, is widely used in nuclear power plants.… more
Abstract:High-resolution CCD/CMOS area detectors coupled to scintillators are commonly used at synchrotrons for a wide range of experiments. While various detectors satisfy resolution, efficiency, speed of operation, and large active area needs for low-energy X-rays (8 to 12 keV), none are suitable for the… more
Abstract:X-ray detector arrays with high energy resolution, high sensitivity and high count- rate performance are required for synchrotron beam-line studies. In many studies conducted with synchrotron beam-lines, the characteristics of available X-ray detectors limit the overall system performance. The… more
Abstract:Dark Matter accounts for nearly 90 percent of all matter in the universe, yet its identity remains one of the biggest mysteries of modern science. Although Dark Matter is invisible to telescopes, astronomers know it is there from the gravitational influence it exerts over galaxies. Using sensitive… more
Abstract:Current radiation detectors used in nuclear physics are typically capable of detecting only one type of radiation well. Therefore, the systems in use require a number of individual detectors for each type of radiation. Furthermore, fast neutron spectroscopy is often very challenging. The research… more
Abstract:The proliferation of weapons of mass destruction such as nuclear missiles and dirty bombs are a serious threat in the world today. Preventing the spread of these nuclear weapons has reached a state of heightened urgency in recent years. Neutron detection is an important component of the overall… more
Abstract:Neutron detectors, traditionally pressurized He-3 tubes, are a common instrument used in nuclear material accounting within the domestic nuclear fuel cycle. Due to the worldwide shortage and high demand of 3He supply, low-cost alternative neutron detection technologies are required to replace He-3… more
Abstract:Implementing nuclear material control and accountability (MC & amp;A) programs at DOE facilities requires new techniques and equipment that maximize material loss detection sensitivity, increase the quality of accountability measurements, minimize material holdup, and reduce the magnitude of… more
Abstract:In field hospitals in/near theatres of operations, and even in smaller mobile medical units, X-ray CT can provide crucial information to first responding providers about soldiers"injuries and allow for quick yet comprehensive blunt and penetrating trauma assessments, which can expedite… more
Abstract:There is a need for a non-destructive, in-situ method to determine the root cause of cracking in aircraft components, and specifically to distinguish between fatigue cracks, cracks due to overload conditions, and cracks caused by corrosion. RMD proposes to develop a system based on an array of eddy… more
Abstract:ABSTRACT: Modern electronics used for military space communications are susceptible to highly energized charged particles such as electrons and protons originating from coronal mass ejections that create geomagnetic storms. There is a need for advanced protection measures that can help minimize… more
Abstract:ABSTRACT: Eddy current testing (ECT) is a widely practiced and critically important nondestructive evaluation (NDE) method used in aerospace, yet it relies on decades-old, wire-coil sensors. Flexible sensors are needed to inspect curved surfaces near the edges of components including wheel bead… more
Abstract:Phase I demonstrated the feasibility of fabricating cost-competitive intermediate band light-harvesting solar cells with high conversion efficiency, through a combination of intermediate band physics and the unique structure of our proposed material. Phase II will continue the research, produce… more
Abstract:While many applications may have access to harvestable energy in the form of solar radiation (or other ambient light), wind, environmental vibration, or wave motion, not all do. In this proposal, RMD targets the most challenging applications, sensors that must operate for many months or years and… more
Abstract:DESCRIPTION (provided by applicant): Radionuclide-guided intraoperative probes increase the specificity of tissue biopsies, enable minimal- access incisions, reduce inpatient hospital utilization, and contribute to improved patient recovery. At present, most such probes on the market are non-imaging… more
Abstract:DESCRIPTION (provided by applicant): Discovery research in the pharmaceutical/biotech industries utilizes high throughput, label-free drug binding cell-based assays, many of which are functional assays. In such instances, the receptor-ligand interaction isonly an indirect measurement of binding and… more
Abstract:DESCRIPTION (provided by applicant): DNA damage threatens the longevity and functionality of cells, and is common to the pathogenesis of many diseases. Better tools are needed for clinical identification and research into mechanisms underlying DNA oxidation, deamination, and hyper/hypomethylation,… more
Abstract:Global analysis of serum lipoprotein subclasses requires a platform that measures size distributions of lipoprotein particles identified by apoprotein content. We propose to employ an innovative methodology based on superparamagnetic and birefringent nanoparticles that bind to supramacromolecular… more
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