Abstract:DESCRIPTION (provided by applicant): Systemic sclerosis (SSc) or diffuse scleroderma is a complex, chronic, autoimmune, connective tissue disease which primarily causes skin thickening and hardening in addition to interstitial fibrosis of lungs, gastrointestinal tract and arteries. Estimates of the… more
Abstract:DESCRIPTION (provided by applicant): Idiopathic pulmonary fibrosis (IPF) is a progressive, agonizing, debilitating and routinely fatal disease that afflicts 200,000 individuals in the United States and five million patients worldwide. There are currentlyno effective treatments available for this… more
Abstract:DESCRIPTION (provided by applicant): Myocardial infarction (MI) is a significant cause of morbidity and mortality in the U.S. H2 Relaxin (H2R) is a Phase III clinical trial-stage peptide that exhibits both anti-inflammatory and cytoprotective activities which can potentially be harnessed for the… more
Abstract:The objective of this project is to develop a portable, passive system for rapid and efficient blood component separation. While a number of macroscale devices (based on centrifugation) are routinely employed in laboratory settings to separate red blood cells (RBCs) and platelets from plasma, they… more
Abstract:ANTEOS, Inc. proposes to develop new generation of photonic crystal laser diodes with narrowed emission spectrum, improved thermal stability and overall performance for application in diode-pumped alkali vapor lasers (DPAL) systems. Already demonstrated proprietary process will be employed for… more
Abstract:For humans and robots to effectively work together, they must share a common understanding of concepts defining the environment and the relationship of those concepts. In this proposal, we present an approach for dynamic interface creation which takes advantage of a robot-centric ontology. We first… more
Abstract:ABSTRACT: When a structure breaks up following a blast event, it allows the blast wave to propagate through a new opening into another airspace; this continuation of the blast wave is called"secondary blast"and may cause damage to elements in the other airspace. Each step in this process… more
Abstract:We propose to design a compact, high-precision, single-axis accelerometer based on atom interferometry that is applicable to operation in space environments. Our design will emphasize reliable operation and minimization of the acceleration noise floor, bias drifts and scale factor instability. Laser… more
Abstract:AOSense has successfully designed and fabricated numerous laser systems for applications ranging from a rubidium Bose-Einstein condensate (BEC) apparatus to ultracold cesium and rubidium atom trapping. This SBIR topic is well-matched to our experience in designing integrated, rugged laser systems… more
Abstract:AOSense proposes an atom interferometer based inertial measurement unit that is capable of meeting the navigational requirements of surface ships and submarines. Real-world applications require extensive optimization of various interferometer design choices in order to deal with platform dynamics.… more
Abstract:AOSense has successfully designed and fabricated numerous cold-atom-based sensors, including lasers, vacuum systems, optomechanics and control electronics. This SBIR topic is well-matched to our experience in developing systems for the manipulation of ultracold atoms. We propose to design and… more
Abstract:We propose to build a compact, high-precision single-axis accelerometer based on atom interferometry that is applicable to operation in space environments. Based on our successful Phase I design, the proposed accelerometer emphasizes reliable operation and exceptional acceleration sensitivity. It… more
Abstract:ABSTRACT: The objective of this proposal is to develop new techniques for addressing dynamic scheduling needs of a production environment in the MRO (Maintenance, Repair & Overhaul) industry where unknown repair issues force continuous schedule modifications. The existing techniques involve… more
Abstract:ABSTRACT: The objective of this proposal is to develop 202 inspection techniques that standardize both the inspection process and any defect data captured as part of the inspection in support of engineering analysis on 202 processes. The Oklahoma City Air Logistics Center (OC-ALC) current… more
Abstract:DESCRIPTION (provided by applicant): The goal of this program is to develop novel inhibitors of human neutral ceramidase (ASAH2) that are effective as therapeutic agents for Inflammatory Bowel Diseases (IBDs). Sphingolipids are being increasingly recognized as key mediators of inflammation, and are… more
Abstract:DESCRIPTION (provided by applicant): Patient data collected during health care delivery and public health surveys possess a great deal of information that could be used in biomedical and epidemiological research. Access to these data, however, is usually limited because of the private nature of most… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project will address the efficiency issues with existing solar harvesting technology and the excessive power consumed by the power management circuitry. The proposed technology addresses the solar performance issues by including a low-power… more
Abstract:Detectors and radiation monitors for future high energy and nuclear physics experiments must be able to withstand radiation environments several orders of magnitude harsher than those of any current device. At present, most radiation detectors are based on silicon technology, however,… more
Abstract:The objective of this SBIR effort is to develop controlled-impedance ground planes with reduced weight and thickness, and apply them antennas capable of operation at frequencies from 30 MHz to 600MHz without significant impact on aerodynamics, and designed to occupy the smallest practical surface… more
Abstract:Objective of the proposed research effort is to design, build and test an experimental AJ antenna for GPS receiver and Iridium transceiver functionality and to develop novel signal processing techniques without compromising the AJ suppression capability of either of the two systems. The AJ antenna… more
Abstract:DESCRIPTION (provided by applicant): Research at the intersection of limnology and public health is showing that toxins produced from cyanobacteria act as an environmental trigger for Amyotrophic Lateral Sclerosis (ALS) commonly known as Lou Gehrig's Disease. Additional linkages are being made… more
Abstract:This Phase II proposal is submitted to further develop and Validate materials and process engineering of the space environment stable, multifunctional conductive thermal control material system (TCMS) that can be applied to space hardware and can enables the hardware to carry higher leakage current… more
Abstract:Use of data from multiple sensors provides the opportunity for improved ballistic missile defense search and tracking. Algorithms for combining multi-sensor data are required. Ballistic missile defense sensor data fusion is a challenging problem because of incompatibility in coordinate systems for… more
Abstract:ABSTRACT: Applied Mind, Inc. (AMI) proposes an effort to design and implement two installations of their Modular Workstation System. The proposed installations will include modular hardware elements and key operational software elements that will include a smart chat application and a one-click… more
Abstract:Middle-wave infrared (MWIR, 3-5¿¿m) photodetectors are of great importance in numerous NASA applications, including thermal remote sensing for carbon-based trace gases (CH4, CO2, and CO), heat capacity mapping for earth resource locating, environment and atmosphere monitoring, and IR spectroscopy.… more
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