Abstract:DESCRIPTION (provided by applicant): Chemotherapy drugs tend to be highly cytotoxic and genotoxic, with well-documented carcinogenic, mutagenic, and teratogenic effects. Long-term occupational exposure to these highly toxic drugs presents serious health risks (e.g., cancers, infertility,… more
Abstract:DESCRIPTION (provided by applicant): The study of retinoblastoma, a childhood tumor, has provided numerous insights into cancer biology. Perhaps most significantly, this work has revealed that cancers can develop in response to mutations in tumor suppressor genes. Tumor suppressor mutations account… more
Abstract:Constitutively activated forms of ALK caused by genetic aberrations have been shown to cause an expanding variety of human cancers. The FDA recently approved the Pfizer drug Xalkori (crizotinib) to treat patients with non-small cell lung cancers (NSCLC) that express ALK. Numerous other… more
Abstract:Lung cancer is the main cause of cancer mortality worldwide with 80% non-small cell lung cancer (NSCLC) in type and mainly driven by three mutually exclusive oncogenes, EGFR, KRAS and ALK (collectively between 30-60% of all NSCLC cases). Oncogenic driverssuch as ROS1 and RET fusions and DEPDC1… more
Abstract:DESCRIPTION (provided by applicant): The alarming increase in incidence of infections caused by drug-resistant bacteria has created an urgent need for new antibacterial agents. We are developing a novel class of small molecule antibiotics ( TZUs ) targeting PolC, the replicative DNA polymerase in… more
Abstract:DESCRIPTION (provided by applicant): This Phase I SBIR will develop ICPCheck, the first long term implantable, non-invasively readable intracranial pressure (ICP) monitor for hydrocephalus patients. This device will result in improved clinical management of hydrocephalus by providing a rapid and… more
Abstract:DESCRIPTION (provided by applicant): Polgenix, Inc. is developing an imaging instrument, the 2-photon ophthalmoscope , or 2PO , with the capability for non-invasive, repetitive and high-resolution imaging of biochemical processes within human retina.This device will allow early detection of… more
Abstract:DESCRIPTION (provided by applicant): In recent years there has been increased interest throughout the world in the use of proton radiation therapy for treatment of cancer. Currently, there are only 9 operational centers in the US that treat a total of about 7,000 patients per year comprising less… more
Abstract:DESCRIPTION (provided by applicant): The problem of overweight children with intellectual disabilities (ID) has many adverse medical and psychological effects and is of growing concern among professionals in the disability research and advocacy arenas. Toaddress this issue, we propose to develop… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project seeks to increase the cycle life of cathode materials used in lithium-ion batteries by a factor of ten in high-temperature applications by applying protective nanoporous ceramic coatings. SolRayo will investigate the effects that… more
Abstract:DESCRIPTION (provided by applicant): The American Cancer Society estimates that more than 1.5 million new cancer victims will be diagnosed this year in the U.S., and that ~572,000 Americans will die of cancer in 2011.1 More than 13 million Americans are living today with a history of cancer, and… more
Abstract:This Small Business Innovation Research Phase I project will demonstrate a more effective and economical process for extracting the chemical and energy resources from lignocellulosic biomass. Existing lignocellulosic pretreatment technologies use any of a variety of chemicals, heat, and mechanical… more
Abstract:ABSTRACT: AuraSense is developing and commercializing NanoFlare technology as an enabling tool for detecting RNA levels in cells. Current methods for sensing of viral exposure require great amounts of virus particles to be present in blood, or extensive processing of blood to isolate virus-specific… more
Abstract:The objectives of this proposal are to further preclinical development of unique two-photon-activated photodynamic therapy (TPPDT) triads that incorporate a nontoxic porphyrin photosensitizer, a tumor targeting group, and an imaging functionality, providing for noninvasive image-guided treatment of… more
Abstract:This Small Business Technology Transfer Phase II project seeks to address the unmet need for high-throughput, cost effective tools to model the metastasis of brain cancer cells. The proposed Phase II work will achieve three key objectives necessary for broad adoption: 1) eliminating the use of… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project proposes to optimize and demonstrate the scale-up of nanostructured anti-reflective coatings (ARCs) to meet the specifications of solar energy customers using high-performance processes along with a novel solution-phase synthesis and… more
Abstract:DESCRIPTION (provided by applicant): The proposed effort is aimed at the development and evaluation of a wireless electronic location system for reporting the location of individuals with autism and other cognitive disabilities, who may wander or elope. This is a very vexing and routine problem for… more
Abstract:DESCRIPTION (provided by applicant): The proposed effort is aimed at the evaluation of a wireless electronic location system for reporting the location of individuals with Alzheimer's Disease and other Dementia (ADOD), who tend to wander or elope. This isa very vexing and routine problem for… more
Abstract:Over the past decade, rural school systems have seen a rapid expansion in the number of Hispanic/Latino students who enter school with limited and non-English speaking abilities, and rural schools are being challenged to accommodate this rapid population growth and the education of students with… more
Abstract:This Small Business Innovation Research Phase II project is focused on improving biofuel fermentation processes by developing phage products designed to inhibit bacteria that reduce biofuel fermentation efficiencies. This product will improve biomass conversion efficiencies in the biorefinery. One… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will pursue an innovation that can dramatically improve traffic mobility and safety. This study is based on an open wireless sensor network platform that supports many sensing modes, and time-stamps all measurements. The sensing… more
Abstract:DESCRIPTION (provided by applicant): Aptamers are nucleic acid based affinity reagents that can be selected in vitro from large combinatorial libraries. As an affinity reagent they have inherent advantages as they are chemically synthesized, thermostable,immunologically neutral, significantly… more
Abstract:Modern Synchrotrons are capable of significant per pulse x-ray flux, and time resolved pulse- probe experiments have become feasible. These experiments provide unique demands on x-ray monitors, as the beam position, flux and arrival time all potentially need to be recorded for each x-ray pulse. … more
Abstract:Despite concerted efforts on both the part of the food industry and Federal regulators, already in 2011 there have been Salmonella foodborne illnesses in 31 U.S. states. Salmonella is a leading cause of foodborne illness. It is responsible each year for an estimated 1 million illnesses, 19,336… more
Abstract:This is a critical crossroads for the poultry industry with a majority of consumers demanding minimal or chemical free foods and the ever present threat of foodborne illness from Salmonella and Listeria associated with raw and ready-to-eat (RTE) poultry products. As a potential solution, we have… more
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