Abstract:The goal of this project is to develop STC101, a biosmilar Herceptin . Trastuzumab is a monoclonal antibody made against the HER2 protein that is overexpressed in 20-25% of patients with breast cancer. Because of high cost associated with prescribing Herceptin , a generic version of this drug would… more
Abstract:DESCRIPTION (provided by applicant): Chemotherapy-induced ototoxicity is damage to the inner ear that is caused by the side effects of administered drugs. This can lead to permanent hearing loss and/or tinnitus (continuous ringing in the ear) in the patient. Some of the most common kinds of drugs… more
Abstract:This SBIR Phase II controct application is submitted in response to the invitation that was extended after successful completion of the phase I entitled 'Circulating Tumor Cell Enumeration Product'. The Phase /I will demonstrate dinical utility of the product as a surrogate for tissue… more
Abstract:Combat ration Intermediate Moisture (IM) products use low pH and water content (aw) to discourage bacterial growth. The long-term goal of this proposal is to maintain the microbial stability of ration components over a two-year shelf life while increasing the pH and aw values for an improved… more
Abstract:DESCRIPTION (provided by applicant): Current approaches to treat sudden sensorineural hearing loss (SSNHL) do not maintain inner ear drug concentrations within an appropriate therapeutic window for sufficient lengths of time to achieve therapeutic effect.A novel delivery system for long-term,… more
Abstract:DESCRIPTION (provided by applicant): Pediatric drug development presents many unique challenges in the effective treatment of diseases in children, from adequate dosing information and pediatric-specific testing to palatable flavor profiles and effective delivery formats. A novel technology that… more
Abstract:DESCRIPTION (provided by applicant): This is a Phase II SBIR proposal to increase the throughput of our DNA sequencing instrument to enable whole genome sequencing with high efficiency and accuracy for a cost of under 1000 per genome. In Phase I, we developed a working sequencing assay, a… more
Abstract:DESCRIPTION (provided by applicant): Dengue virus infection is an emerging disease and an expanding global health problem. More than one-third of the world's population is at risk for transmission in tropical and subtropical areas and vaccines are an urgent public health priority. Although… more
Abstract:DESCRIPTION (provided by applicant): Vaccines are urgently needed to slow the spread of the HIV/AIDS epidemic, and immunogens that can induce neutralizing antibodies remain an important goal of vaccine research. An increasing number of human monoclonal antibodies (mAbs) have been isolated in recent… more
Abstract:DESCRIPTION (provided by applicant): Hepatitis B virus (HBV) is a noncytopathic, hepatotropic DNA virus that results in a self-limited acute infection in a majority of otherwise healthy individuals but can also cause chronic infection, particularly in newborns infected by vertical transmission.… more
Abstract:DESCRIPTION (provided by applicant): Development of a vaccine to prevent, or reduce the rate of, HIV infections remains a high priority despite recent setbacks in the field. The lessons from failed and successful experimental programs indicate the need toapply new approaches to HIV vaccine design… more
Abstract:DESCRIPTION (provided by applicant): The 2009 H1N1 pandemic illustrates a critical weakness in our ability to respond to a pandemic threat. The ability to ramp up production of vaccine doses within the critical period from the discovery of the threat is hindered by two major supply constrictions: 1)… more
Abstract:DESCRIPTION (provided by applicant): The SHARE Program: Supporting Health, Activities, Resources, and Education is a seven-session early stage intervention for care dyads (the IWD and a family CG) that takes advantage of a time when the IWD can still discuss the diagnosis and plan for the future.… more
Abstract:Interplanetary missions are at the core of NASA's current space exploration program and are expected to lead the way to new resource discovery in the next decade and beyond. In the absence of manned craft, the payoff for a given mission rests in its ability to gather data and transmit it back… more
Abstract:DESCRIPTION (provided by applicant): The overall goal of this Phase 2 STTR is to develop and commercialize a novel approach for allergen specific immunotherapy as a treatment for severe food allergy. Currently treatment to prevent severe food reactions isa major unmet need. There is no effective… more
Abstract:The proposed innovation is a heterogeneous multi-robot team developed as a platform for effective subsurface planetary exploration. State-of-art robotic exploration is based on single-robot systems with human controllers augmented by limited automation. This system requires near-constant… more
Abstract:DESCRIPTION (provided by applicant): Portable Lab-on-a-chip Flow Cytometer: Prototype and Application Development NanoSort RESEARCH and RELATED Other Project Information 7. PROJECT SUMMARY The lab-on-a-chip NanoSort device proposed here advances the achievements of the Phase I Beta Prototype project… more
Abstract:Cancer is a complex and diverse disease whose treatment can be improved by more sophisticated early detection and monitoring. NanoSort, Inc. proposes to build a lab-on-a-chip microfluidic device platform that can detect and quantify up to 32 multiplexed analytes for the detection and monitoring of… more
Abstract:DESCRIPTION (provided by applicant): Ion channels are membrane proteins that allow the selective movement of charged molecules through cellular membranes. Many disease states, such as cystic fibrosis, muscular dystrophies, hypertension, and cardiac arrhythmias are caused by ion channel pathologies.… more
Abstract:Optical Engines has developed and demonstrated a high power pump combiner in the co-propagating direction with 94.5% pump efficiency and a 20dB PER with zero brightness drop. This combiner has been tested for extended periods (approx 1 Hr) with 1.5kW of pump power with no degradation. This was… more
Abstract:DESCRIPTION (provided by applicant): Aggregation in antibody therapeutics is a topic of increasing concern in the biopharmaceutical industry, as these aggregates are believed to play an undesirable role resulting in adverse health effects to patients by inducing immunogenicity, altering therapeutic… more
Abstract:DESCRIPTION (provided by applicant): The overall objective of this project is to productize and commercialize a markerless motion capture system for applications in biomechanical and clinical practice. The markerless system, as opposed to traditionally used marker based systems, would provide… more
Abstract:Microchannel Plate event multipliers capable of operation at cryogenic temperatures are currently not commercially available from any supplier. The proposed development of cryogenic-compatible MCPs will enable photon/electron/ion/alpha detection with high spatial resolution and sub-nanosecond event… more
Abstract:DESCRIPTION (provided by applicant): During the past decade, the discovery of kisspeptin peptides and their cognate receptor KISS1R (aka GPR54) has expanded our mechanistic understanding of the hypthothalamic-pituitary-gonadal (HPG) axis. The kisspeptin system has been shown to be an integrator of… more
Abstract:DESCRIPTION (provided by applicant): This Fast-Track SBIR proposal submitted by SoloHealth of Duluth, Georgia, requests grant funds to build and test a multifunction health-screening kiosk. Our current kiosk prototype, EyeSite, has demonstrated efficacy inreaching low income, high health disparity… more
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