Abstract:DESCRIPTION (provided by applicant): An estimated 5.4 million Americans are currently suffering from Alzheimer's disease (AD), and AD cases are expected to rise at an alarming rate, so market potential exists for products, approaches, and/or training thatcan help treat and/or circumvent the… more
Abstract:DESCRIPTION (provided by applicant): Dentin hypersensitivity (DH) is a common problem and the treatment modalities are, if they work at all, short lived. The object of this project is t produce a product that can occlude patent dentinal tubules (the causeof DH) and adhere to the wet interior… more
Abstract:DESCRIPTION (provided by applicant): Diabetic Retinopathy (DR), a vision threatening complication of diabetes, can be managed more effectively if detected early. We propose to enable such early diagnosis by developing a portable retinal imaging instrument- LSC EYE - that will, for the first time,… more
Abstract:DESCRIPTION (provided by applicant): This project will focus on the preparation and evaluation of nonthrombogenic, antibacterial nitric oxide (NO) releasing catheters. Phase 1 of this SBIR will: 1) develop unique NO secreting catheters (14-20 gauge); 2) test them in rabbit and sheep models to… more
Abstract:DESCRIPTION (provided by applicant): The absence of a widely accepted commercially available method to measure glomerular filtration rate (GFR) in animal models and in the clinic has had profoundly negative effects on (i) developing methods and drugs for treating kidney disease, (ii) accurately… more
Abstract:DESCRIPTION (provided by applicant): We hypothesize that a commercially competitive magnetic nanoparticle can be developed to eliminate debris in the preparation of cell cultures, such as stem cells. Current methods to remove unwanted material from healthycultures rely on magnetic negative selection… more
Abstract:DESCRIPTION (provided by applicant): The goal of this proposal is to develop a STAT palm-sized blood counter for monitoring complete blood counts (CBC) with 3-part differential during emergencies. Changes in blood counts can reflect acutely worsening medical conditions. For instance, a rapidly… more
Abstract:EOIR Technologies understands the Army has a requirement for a real time/near real time thin client collaboration environment to support the EW common picture/battle management that integrates with DCGS-A, and does not rely on proprietary technology, extensive hardware or other dependencies that… more
Abstract:EOIR Technologies proposes to develop the Standoff Counter Human Deception Detection Device FLIR As Guide (SCHD3-FLAG) as an innovative non-contact thermal imaging technology. This stand-off collection system will measure the psychophysiological signature of subjects undergoing questioning via pore… more
Abstract:This Small Business Innovation Research project will develop a non-animal based in vitro assay for determining the efficacy of Botulinum (BoNT) neutralizing therapeutics. New technologies are currently needed in order to facilitate the development and approval of BoNT vaccines and therapies and… more
Abstract:DESCRIPTION (provided by applicant): Unknown or poorly understood differences in the potency of therapeutics containing the botulinum neurotoxin Type A (BoNT/A) could result in over or under dosing of patients. The potency of BoNT/A therapeutics is currently assessed using a mouse intraperitoneal… more
Abstract:DESCRIPTION (provided by applicant): Clinical laboratories (CL) practitioners play a crucial role in the detection, diagnosis, and treatment of disease, trauma, and maladies. In fact, 70% of the information used by health care practitioners in making medical decisions comes from the CL. However,… more
Abstract:In our Phase I effort, we propose to develop a technique for passively enhancing target scene object orientation detection for support of post-flight reconstruction. This passive solution will enable dynamic rate reconstruction for pitch, yaw, and roll at rates that range from sub-Hz to 100s of Hz.… more
Abstract:We will apply the test methods that we have developed to assess the performance of Ballistic Missile Defense interceptors in the presence of natural and man-made radiation environments. At the conclusion of Phase II, MDA will have a demonstrated hardware-in-the-loop capability to test the kill… more
Abstract:This Small Business Innovation Research Phase I project attempts to overcome fundamental limitations that are currently inhibiting the realization of much needed low-cost high-performance digital-to-analog converters (DACs), which can accommodate the wide bandwidths of current and future… more
Abstract:This Small Business Innovation Research Phase 2 project targets the realization of a cost-effective solution for achieving increased data throughputs in the crosstalk-constrained copper-medium-based cellular and access backhaul networks, to address the growing demand for capacity experienced in them… more
Abstract:The Urban Forestry Modeling and Prioritization Tools project addresses the research and tasks necessary for creating cost effective, web-based software that assists urban foresters with strategically selecting planting locations in order to maximize impact on both the environment and local… more
Abstract:Nylon fabric is a polyamide that is lightweight, strong and durable. The fabric dries quickly when wet and provides comfort. Nylon is used in multiple applications ranging from apparel, home furnishings, industrial applications and geo-textiles. The cloth specified by this proposal is Mil-C-… more
Abstract:A growing body of research underscores the need to prepare students socially—as well as academically—to ensure successful transition to middle school and foster subsequent academic success. This project team is developing a prototype of a series of web-based interactive games to help students… more
Abstract:DESCRIPTION (provided by applicant): The Advanced Biofidelic Lower Extremity Kids prosthesis (ABLE Kids) project will advance the state-of-the-art of pediatric prosthesis systems by advancing the demonstrably successful Phase I device and refining it intoan ultracompact and lightweight form factor… more
Abstract:DESCRIPTION (provided by applicant): Stiffness and alignment of ankle-foot orthoses (AFOs) should be tuned optimally to maximize their function. Improperly tuned AFO may induce joint pain, reduced ambulatory function, and increased medical complications for patients with stroke. Therefore, the… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project focuses on the further development of an advanced, mobile, easy-to-use, patient-oriented, advanced Home Hemodialysis (HHD) system that minimizes the use of water (less than 6 liters) and medical waste, and importantly, minimizes… more
Abstract:DESCRIPTION (provided by applicant): Over the past several decades, a large number of mental health (MH) practices and interventions have been rigorously tested through randomized control trials and shown efficacious. However, despite availability, evidence-based interventions (EBIs) are rarely… more
Abstract:DESCRIPTION (provided by applicant): Clinical science and its translation into preventive and clinical patient care are the primary means by which the nation's health care goals are fulfilled. NIH's broad mission to improve health outcomes for all people can only be achieved if scientific… more
Abstract:DESCRIPTION (provided by applicant): Non-suicidal self-injury (NSSI) is an increasingly common self-harming behavior among adolescents and young adults, with current estimates of NSSI in youth ranging from 12-37%. Although NSSI is associated with other mental health problems (e.g., depression,… more
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