Abstract:DESCRIPTION (provided by applicant): Approximately 500,000 bone-grafting procedures are performed each year in the United States. Autologous iliac crest bone graft continues to be the gold standard, because it provides essential elements for bone formation: progenitor cells, an osteoconductive… more
Abstract:DESCRIPTION (provided by applicant): Back pain is one of the leading reasons for physician visits in the United States and in many cases requires surgical intervention. In the United States, there are over 500,000 spinal fusion surgeries every year, and the frequency of these surgeries is projected… more
Abstract:DESCRIPTION (provided by applicant): Over 700,000 surgical hernia repairs are performed each year in the United States and despite recent advances, a significant rate of recurrence persists. Of these surgeries, 100,000 are for incisional or visceral herniarepairs, which cost 1.7B annually and have a… more
Abstract:DESCRIPTION (provided by applicant): Calvarial reconstruction continues to present challenges for surgeons. Although the gold standard for restoration of the skull is autologous bone, particularly from the removed flap, substitutes are often necessary dueto the flap becoming infected or infiltrated… more
Abstract:DESCRIPTION (provided by applicant): Burn injuries and chronic wounds present a significant burden to patients and the US healthcare system. Each year in the US, there are 450,000 burns that require medical treatment and 45,000 burns that require hospitalization. One of the most common causes of… more
Abstract:DESCRIPTION (provided by applicant): As the percentage of the U.S. population aged 65 and older grows from the 12.9 percent reported in 2009 to the estimated 19 percent projected in 20301, it is becoming increasingly important that the many factors affecting the health and well being of this portion… more
Abstract:ABSTRACT: The extreme toxicity of organophosphate (OP) chemical warfare agents (CWA) is due to their specific, rapid, and irreversible reaction with cholinesterase enzymes. A significant portion of this reactive nature of OP agents is directly due to the unique metabolically active environment… more
Abstract:Dried blood spots (DBS) analysis has many advantages over standard liquid blood sample testing including: small sample size, ease of blood sampling, room temperature storage, minimal storage size requirement, and ease of shipping. Although these advantages are significant, there are still problems… more
Abstract:Agave BioSystems proposed to develop a system of Rapidly Adaptable Nanotherapeutics (RANT) by combining advanced bioformatics, with DNA-based nanoparticles, peptide nucleic acid (PNA) antisense oligonucleotides, and cell permeating peptides (CPPs). Advanced bioinformatics computing will allow for… more
Abstract:One major cause of the widespread of drug-resistant and virulent bacteria pathogen is the horizontal gene transfer of resistance and virulence genes in the form of plasmids. As proof-of concept for this Phase I effort, Agave BioSystems proposes to develop combinatorial therapeutics by inhibiting… more
Abstract:Wounds infected with drug-resistant Gram-negative bacteria can increase morbidity, hospital length of stay and cost. Among these Klebsiella pneumoniae and Pseudomonas aeruginosa have become important causes of concern in military personnel wounded in battlefield. New classes of antimicrobial agents… more
Abstract:With no clinically approved antiviral therapy available for treatment of flavivirus infections, the development of efficient vaccines and antiviral agents for prevention and treatment of infections is an urgent health priority. A combination of structure-based in silico models, in vitro and… more
Abstract:Bacterial enteric pathogens causing travelers"diarrhea (TD) in developing countries include enterotoxigenic E. coli (50%), Camplyobacter jejuni, Shigella sonnei and Shigella flexneri, while Norovirus is a common viral cause. High risk regions for TD include areas where US service members are… more
Abstract:Field testing of water samples is needed for broad and sensitive detection of toxic industrial chemicals, or TICs. The use of unicellular organisms in cell-based detection systems is particularly advantageous both because these organisms have developed a natural ability to respond to environmental… more
Abstract:DESCRIPTION (provided by applicant): CyberMOD: A Gentle-Slope Cyberlearning Infrastructure to Support STEM Education Abstract This Small Business Innovation Research Phase I project investigates a new gentle-slope cyberlearning infrastructure that introduces students to simulation authoring via a… more
Abstract:A Neutron detection device is an indispensable tool for power, medical, defense, and homeland
security applications. The proliferation of weapons of mass destruction such as nuclear weapons
is a serious threat in today’s world. Low cost, low power, high performance, rugged and portable
Abstract:Agiltron proposes to develop an extremely compact and high sensitivity uncooled near- and mid-infrared (NMIR) spectrometer engine for planetary compositional analysis and mapping. In this program, we will produce lead salt-based IR detector materials with single crystalline-like oriented thin film… more
Abstract:Leveraging Agiltron"s industrial leading developments and production of high speed fiber optical components and modules as well as commercial photonic devices, we propose to develop a new class of high performance tunable RF filters and filter banks for advanced RF systems. The approach is… more
Abstract:ABSTRACT: In this STTR program, Agiltron and Iowa State University (ISU) jointly propose to develop simple material and structural solutions that enable directionally dependent emission in the infrared regime. The highly directional infrared emission has extremely narrow emission patterns and a… more
Abstract:ABSTRACT: Leveraging Agiltron"s organic thin film transistor (OTFT) array design and printing technology and industrial leading developments and productions uncooled mid-infrared (mid-IR) detectors and detector arrays, we propose to develop a new class of high performance printed mid-IR… more
Abstract:We propose to develop a device that is capable of rapidly identifying and classifying pollen from a broad sampling base using surface enhanced Raman spectroscopy (SERS). The proposed Raman device is designed to spectroscopically examine, identify and classify the spatial and temporal origin of… more
Abstract:Agiltron, in partnership with Worcester Polytechnic Institute (WPI), will build and test the Infrared Robotic Imaging System (IRIS), a stereoscopic vision system to provide 3-D location and mapping capability for the navigation of firefighting robotic systems. IRIS is based on Agiltron"s… more
Abstract:Loveraging on Agiltron's experience in optical fiber components, Agiltron proposed a coherent single-mode fiber (SMF) spatial filter array (SFA) with a gradient index fiber (GIF) lens array pair to meet NASA's application of planet exploration. There are several advantages over the current… more
Abstract:DESCRIPTION: We propose to build a portable, field-deployable blood test monitor to immediately identify toxic chemical agent buildup in persons suspected of having been exposed to such agents. The technology we plan to utilize is surface- enhanced Raman scattering to look for the presence of… more
Abstract:Realizing a practical mode lock fiber oscillator with both high repetition rate and high pulse energy has been a very challenge work of the ultrafast fiber laser for more than twenty years. Although many mode lock fiber laser structures have been attempted since the 1990 & apos;s, none has fully… more
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