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Year:2012
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Displaying 5376 – 5400 of 5642 Awards
Company: KADMON CORPORATION, LLC Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Cytomegalovirus (CMV) causes significant disease and mortality in populations with weakened immune systems, including cancer patients, organ transplant recipients, and HIV-infected people. Additionally, it is the most common cause of congenital infection… more
Company: LIVERMORE INSTRUMENTS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Despite the human cost of tuberculosis (TB), the disease remains difficult to diagnose and thus to control. One-third of the world's population is infected with M. tuberculosis. Every year, more than 9 million people develop active TB and 1.7 million people… more
Company: SERACARE LIFE SCIENCES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Rapid Test for Recent HIV Infection and Incidence Panels for Assay Evaluation Project Summary Accurate estimates of HIV incidence are required for monitoring the epidemic, for targeting resources, and for evaluating the effectiveness of various interventions.… more
Company: JUNCO LABS, LLC Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Although nanomaterials have tremendous potential to improve human health, it has remained surprisingly elusive to leverage their properties to produce real clinical impact. One of the most promising applications of nanoparticles is in sensors for detection of… more
Company: TOMEGAVAX, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): The goal of this project is to establish human cytomegalovirus (HCMV) as a new human vaccine vector platform. In non-human primate models, CMV-vectored vaccines have shown unprecedented protection against immunodeficiency viruses and similar vaccines are… more
Company: VIRTICI Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Each year, an estimated 1.7 million patients in the U.S. experience a hospital infection (CDC). Approximately 750,000 of these infections lead to severe sepsis, with over 200,000 patients dying [1]. As a result, 16 billion (40% of all intensive care unit… more
Company: VIRTICI Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Approximately 22 million people in the US suffer from asthma (National Heart, Lung, and Blood Institute). As a result, the annual economic cost of asthma is 19.7 billion. Globally, an estimated 300 million people worldwide have asthma, with 250,000 annual deaths… more
Company: OSEL, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Women bear the brunt of the global AIDS epidemic due in part to their inherent social and biological vulnerability. Biologically, the cervical and vaginal mucosae are vulnerable targets for HIV transmission. In healthywomen of childbearing age, mucosal antibodies… more
Company: SIXAL CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): The overall goal of this SBIR application is to develop and commercialize a next generation allergy biologic therapy. This novel therapeutic, an anti-IgE monoclonal half antibody, targets the surface-bound IgE on allergic effector cells and functionally blocks… more
Company: WIBI WORKS, LLC Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): The First Locally Acting Anti-Inflammatory Stem Cell-Based Therapy for Rheumatoid Arthritis Despite improved therapy; rheumatoid arthritis (RA) remains a significant unmet medical need. The long-term goal of this project is to advance the first stem cell-based… more
Company: IMBED BIOSCIENCES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): The health care burden associated with treatment of chronic and burn wounds amounts to more than 25 billion annually in the U.S., involving 8.6 million patients. One recent advance in wound care has been the development of biologic dressings that contain… more
Company: VALITOR, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION: In 2010, more than 875,000 Americans with diabetes were diagnosed with a lower extremity ulcer. Failed closure of these wounds results in more than 73,500 lower extremity amputations annually. Valitor, Inc. is developing protein-polymer therapeutics to overcome the microvascular… more
Company: LIVIONEX, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): The proposed Phase I SBIR grant, Livionex Inc. will test and develop a novel approach for the early treatment of burn injuries. Livionex will leverage its knowledge in the use of localized metal modulation, particularly, the control of iron and calcium in the… more
Company: MILO BIOTECHNOLOGY, LLC Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Rare muscular dystrophies span a wide range of etiologies and symptoms but nearly all neuromuscular diseases are characterized by progressive muscle weakness that is unchecked by existing therapies. Myostatin inhibitionis the target of a number of developing… more
Company: JB THERAPEUTICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Systemic sclerosis (SSc; scleroderma) is a complex multisystem autoimmune disease of unknown cause associated with early transient inflammation and vascular injury followed by progressive fibrosis affecting skin and internal organs; most frequently esophagus,… more
Company: SIMULCONSULT, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Empowering Physicians with Evidence-Based Decision Support for Pediatric Rheumatologic Diagnoses This project responds to a critical shortage of pediatric rheumatologists by enlisting top rheumatologists to encapsulatethe diagnostic information in their field in… more
Company: AYER AND KURIS RESEARCH ENGINEERING, INC Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): A unique challenge inherent in the study of multi-component mind-body interventions is objectively quantifying measures of adherence, proficiency, and functional dosage. Because variability in proficiency of practice can significantly alter physiological… more
Company: AUTHENTECHNOLOGIES LLC Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): In this proposal, we outline an innovative approach to accomplish at least two of NCCAMs priorities: validating DNA methods for botanical identification and developing complex DNA-authenticated botanical identity standard reference materials (BI-SRMs); this will… more
Company: AGONOX, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Current cancer management options include chemotherapy, radiation therapy, surgery, immunotherapy, monoclonal antibody therapy and other experimental treatments. The treatment regimen is dependent upon the location andgrade of the tumor, the stage of the disease… more
Company: 3P BIOTECHNOLOGIES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Cervical cancer, which is caused by HPV infection, is characterized by the progressive formation of dysplastic lesions, known as cervical intraepithelial neoplasia (CIN). Although vaccinations for the prevention of cervical cancer have been developed, the… more
Company: MISSION MEDICAL, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Radiofrequency ablation (RFA) is widely and increasingly utilized in cases where surgery is not possible as a minimally invasive treatment for cancer. Despite rapid adoption of this technique due to its proven success in treating smaller tumors, however,… more
Company: GERINDA THERAPEUTICS, INC Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Acute Myeloid Leukemia (AML) accounts for a high percentage of all adult leukemia cases. Although most patients at first respond well to conventional chemotherapy, there is a high rate of relapse and patients become refractory to front-line treatment, which bears… more
Company: IMMUNGENE, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): This proposal is designed to optimize the monoclonal antibody-IFN fusion molecule (mAb-IFN) by introducing several point mutations in the IFN part of the molecule. Recently, we discovered that mAb- IFN fusion molecule is about 4 log units more potent at… more
Company: TYMORA ANALYTICAL OPERATIONS, LLC Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): With recent technical advances, multiple important signaling pathways that may be the causes of human malignancy have continuously been discovered and dissected. The vast majority of these signaling pathways involve reversible protein phosphorylation, and the… more
Company: TYMORA ANALYTICAL OPERATIONS, LLC Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): With recent technical advances, multiple important signaling pathways that may be the causes of human malignancy have continuously been discovered and dissected. The vast majority of these signaling pathways involve reversible protein phosphorylation, and the… more
Displaying 5376 – 5400 of 5642 Awards
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