Abstract:The Hsp90 inhibitor 17-DMAG will be encapsulated in a nano-sized liposome formulation that is long-circulating with controlled drug release properties in tumor tissue. Reformulation of 17-DMAG in a nanoliposome will increase the dose intensity of 17-DMAG in solid tumors while reducing the hepatic,… more
Abstract:This project aims to develop a stabilized epothilone B (Epo B)-loaded micelle for the intravenous delivery of Epo B to solid tumors. The data should demonstrate that Epo B is encapsulated within the micelle with weight-loadings in the range of 1-5% wt/wt Epo B. Crosslinking chemistries will be… more
Abstract:The aim of this project is to reformulate a highly lipophilic anti-cancer agent, valrubicin (AD-32) that has only been approved for vesicular treatment of bladder cancer due to its poor dose limiting toxicities due to poor water solubility. LipoMedics willreformulate valrubicin (AD-32) utilizing a… more
Abstract:To modify the Contractor's ID-Cap medication adherence system to add biometric identification and secure communication systems that enable compliance improvement programs. Thr result is that it can allow for accurate, real-time monitoring of medication adherence with no effort by the patient.… more
Abstract:We have entered a stage where there are plentiful of therapeutic agents either in clinical use or in development for clinical use. The difficulty is not in finding drugs for treatment, but to tailor fit treatment to the patients- personalized medicine. Personalized medicine demands both… more
Abstract:Cardiovascular disease is a leading cause of morbidity and mortality and both high LDL-C and low HDL-C remain validated factors that predict and contribute to risk. Reliance on the lipid, cholesterol, as the surrogate marker to measure total LDL and HDL has limitations and provides inadequate… more
Abstract:Folic acid is a water-soluble vitamin that serves as a cofactor in 1-carbon transfers required for DNA replication. Humans lack the enzymes to synthesize folate, so dietary intake is necessary. Its deficiency is associated with neural tube defects (NTDs) in fetuses. The global burden of folate… more
Abstract:Breast, cervical, and colorectal cancer can be successfully prevented and/or diagnosed and successfully treated at the earliest stages through use of appropriate and timely screening and adequate follow-up and care coordination. Recognizing the importance of cancer screening, groups like the… more
Abstract:A rapid respond to outbreaks critically depends on laboratory confirmation of suspected measles cases. In general, the turnaround times for serologic test results provided by the WHO Measles/Rubella Laboratory Network are adequate; however, results from specimens collected in remote areas can be… more
Abstract:ABSTRACT: Airborne Innovations proposes to develop a subminiature high definition video transmission system and command and control link. We will emphasize technologies needed for practical use of such a system. From our expertise in UAV imaging systems we are uniquely qualified to provide the… more
Abstract:The overall objective of the program is to develop innovative concepts for more efficient and reliable clutch plates for the JSF Fan Duct Clutch. Carbon-carbon composite clutch plates can meet a 1,500 engagement life requirement for a lift fan clutch, but this is at least two times less than the… more
Abstract:Advanced ceramic matrix composites (CMC) are required for various components in the propulsion system along the hot gas path, where pressures up to 3000 psi and flame temperatures from 4000 degrees F to 5000 degrees F are encountered. In order to achieve the lightest possible and optimal component… more
Abstract:ABSTRACT: The objective of this Phase I SBIR effort is to develop and demonstrate a multifunction, multi-beam X-band subarray that is capable of simultaneously supporting communications for satellite operations and radar for air/space surveillance. Under this proposed effort, Alpha Omega… more
Abstract:Although biodiesels have been increasingly used in automobiles, trains, commercial aircrafts and heating systems, they are not currently used in the military aircrafts and land vehicles because they typically do not meet the JP-8 performance criteria as specified by MIL-PRF-83133E. Unintentional… more
Abstract:In this SBIR program, AlphaSense, Inc. teamed with the Center for Non-destructive Evaluations at Iowa State University to develop a compact, low cost handheld sensor for non-destructive material case depth verification. In phase I, we have proven the feasibility of using an alternating current… more
Abstract:For supporting NASA's Robotics, Tele-Robotics and Autonomous Systems Roadmap, we are proposing the "Evolutionary Autonomous Health Monitoring System" (EAHMS) for planetary exploration, which will provide an integral flexible diagnostics and prognostics framework by advanced and novel… more
Abstract:American GNC Corporation (AGNC) and Louisiana Tech University (LaTECH) are proposing a breakthrough technology consisting of an innovative system for facilitating the monitoring and management of NASA test facilities (such as rocket engine test stands) and widely distributed support systems (WDSS).… more
Abstract:The objective of this project is to demonstrate the feasibility of a Gyrocompassing Based Attitude and Azimuth Determination System Using MEMS Inertial Sensors. This attitude and azimuth determination system can be used in a handheld laser range finder for providing targeting capability for… more
Abstract:To support U.S. Navy mission readiness for carriage life monitoring and dynamic event tracking of external stores, AGNC is proposing an autonomous vibration-based system that performs event detection and identification (EDI). The AISTS builds on state-of-the-art spectrum data analysis, embedded low… more
Abstract:ABSTRACT: The purpose of this SBIR is to aid in the design of a multi-purpose non-destructive in-spection test kit with the end goal of decreasing the cost to perform POD studies. During this Phase II project, American Testing Services and its subcontractor, Mound Laser and Photonics Center, Inc.… more
Abstract:Nanosatellites are receiving increased interest since they are proving reliable for surveillance, communication and other space missions. Also, the possibility of launching "constellations" of them offers unique capabilities for low-cost experimentation, sensing and communications in… more
Abstract:A spacecraft thermal control system must keep the cabin (both air and its structure if manned) and electronic equipment within a narrow temperature range even though the environment may vary from very cold to warmer than room temperature. Since water is safe to use and an excellent coolant (other… more
Abstract:On-site activated decontaminants are ideal because the activated solution is highly reactive and can quickly destroy chemical and biological warfare agents, but prior to activation the decontaminant ingredients can be safely stored for years, shipped, handled and have a long shelf life. TDA"s… more
Abstract:TDA Research, Inc proposes to develop a compact, low power, high life-cycle computer controlled Programmable Force Generator (PFG) that can generate any force between 0 and 700 lbf during any phase of the exercise motion. The proposed device uses a closed loop control system to maintain the… more
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