Abstract:Tumor Paints for real-time intraoperative visualization of solid tumors enable more complete resection while sparing surrounding normal tissue. For brain tumors this is of paramount importance, since removal of additional tissue can unnecessarily increasecognitive and functional impairment. The… more
Abstract:Historically, tissue sample analysis was limited due to lack of practical high throughput techniques. An advance in tissue analysis came with the invention of the multitumor tissue block. This technology was improved upon, refined and eventually evolvedinto the Tissue Microarray (TMA), currently a… more
Abstract:Following ablative surgery for thyroid cancer, follow-up management of patients includes monitoring for radioiodine uptake or serum TG levels. Recombinant human thyroid stimulating hormone (rhTSH) is currently used to increase the sensitivity of measurements in patients on thyroid hormone … more
Abstract:This technology introduces a new non-invasive, biopsy-adjunct with a MNP platform for targeted tumor delivery. It employs closely sized magnetic nanoparticles (CS-MNP's) for determining their concentration and spatial distribution in tumor vasculatures asmeasured by magnetic resonance imaging… more
Abstract:Surgical resection of malignant tumors is the single most effective therapy for cancer. Long-term patient outcomes are strongly determined by the extent to which the surgeon can completely remove all diseased tissues. Present cancer imaging and detectionmethods often fail to provide a clear… more
Abstract:TP-0413 is a novel small molecule inhibitor of the BMP pathway that has significant potential to be developed to treat anemia of cancer. Anemia of cancer is cytokine driven and results in the up-regulation of a liver hormone called hepcidin through the function of BMP receptors. Increased hepcidin… more
Abstract:Cancer is a leading cause of death that affects millions of lives across the world. It is a complex disease that is likely to require multifactorial measurements for earlier and more accurate diagnosis and patient stratification. Tissue biopsies and fine needle aspirates are commonly collected… more
Abstract:The Hsp90 inhibitor 17-DMAG will be encapsulated in a nano-sized liposome formulation that is long-circulating with controlled drug release properties in tumor tissue. Reformulation of 17-DMAG in a nanoliposome will increase the dose intensity of 17-DMAG in solid tumors while reducing the hepatic,… more
Abstract:This project aims to develop a stabilized epothilone B (Epo B)-loaded micelle for the intravenous delivery of Epo B to solid tumors. The data should demonstrate that Epo B is encapsulated within the micelle with weight-loadings in the range of 1-5% wt/wt Epo B. Crosslinking chemistries will be… more
Abstract:The aim of this project is to reformulate a highly lipophilic anti-cancer agent, valrubicin (AD-32) that has only been approved for vesicular treatment of bladder cancer due to its poor dose limiting toxicities due to poor water solubility. LipoMedics willreformulate valrubicin (AD-32) utilizing a… more
Abstract:To modify the Contractor's ID-Cap medication adherence system to add biometric identification and secure communication systems that enable compliance improvement programs. Thr result is that it can allow for accurate, real-time monitoring of medication adherence with no effort by the patient.… more
Abstract:We have entered a stage where there are plentiful of therapeutic agents either in clinical use or in development for clinical use. The difficulty is not in finding drugs for treatment, but to tailor fit treatment to the patients- personalized medicine. Personalized medicine demands both… more
Abstract:Cardiovascular disease is a leading cause of morbidity and mortality and both high LDL-C and low HDL-C remain validated factors that predict and contribute to risk. Reliance on the lipid, cholesterol, as the surrogate marker to measure total LDL and HDL has limitations and provides inadequate… more
Abstract:Folic acid is a water-soluble vitamin that serves as a cofactor in 1-carbon transfers required for DNA replication. Humans lack the enzymes to synthesize folate, so dietary intake is necessary. Its deficiency is associated with neural tube defects (NTDs) in fetuses. The global burden of folate… more
Abstract:Breast, cervical, and colorectal cancer can be successfully prevented and/or diagnosed and successfully treated at the earliest stages through use of appropriate and timely screening and adequate follow-up and care coordination. Recognizing the importance of cancer screening, groups like the… more
Abstract:A rapid respond to outbreaks critically depends on laboratory confirmation of suspected measles cases. In general, the turnaround times for serologic test results provided by the WHO Measles/Rubella Laboratory Network are adequate; however, results from specimens collected in remote areas can be… more
Abstract:First responders operate in emergency situations that require ruggedized gear that can survive temperature, impact, and moisture. Utilizing the
communication devices that first responders already carry on them has many benefits including: always on-scene, reduced cost of distributing
Abstract:This proposal develops a new system to track the past location of persons and materiel, based on rapid and accurate collection and classification of pollen grains. Plant pollen stands out among naturally occurring geolocation markers for the following reasons: Pollen is abundant and collects on… more
Abstract:SA Photonics has developed a new class of digital night vision head mounted displays, which represent a breakthrough in digital night vision with their low-profile digital sensors and high resolution, wide field of view displays. For the first time in a head mounted display (HMD), night vision… more
Abstract:Survival rates for soldiers injured by IED blasts and similar trauma are enhanced by prompt, high-quality medical care. Among the survivors, however, increasing numbers report symptoms of Traumatic Brain Injury (TBI). Mild and moderate TBIs with no skull-penetrating wounds are difficult to detect… more
Abstract:SA Photonics is pleased to propose the development of the SENTRY hyperspectal situational awareness system for the detection of liquid chemical agents in the asymetrical terrorist warfare scenario. SA Photonics will be teaming with world renown experts from the University of Arizona for the… more
Abstract:SA Photonics is pleased to propose our FALCON-HBS, High Bandwidth line of site beam Stabilization system for airborne sensor and laser systems such as ALTB and ABIR. Using SA Photonics ultra-compact 20Khz sample rate fiber optic gyroscopes for inertial reference, proprietary Fast Steering Mirror… more
Abstract:ABSTRACT: As the data rates of satellite communication links increase due to inclusion of high resolution imagery and video, a high bandwidth backbone network is required to support all uses of the network. Free-Space Optical (FSO) communication links have the ability to provide very high data… more
Abstract:ABSTRACT: SA Photonics is pleased to propose the development of the SENTRY multi-function laser system. SENTRY incorporates SA Photonics high energy fiber optic technology and AccuPoint beam control system to enable precision tracking of space debris BENEFIT: Orbital planes are getting… more
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