Abstract:DESCRIPTION (provided by applicant): The adoption of electronic health record (EHR) systems is a national healthcare priority. However studies show massive physician productivity drop of up to 25-40% upon transition to EHR. The majority of workflow delay is based on the need to perform manual… more
Abstract:DESCRIPTION (provided by applicant): Post-traumatic stress disorder (PTSD) and its consequences place a large burden on the public and on the individuals who suffer from it, yet the clinical evaluation of PTSD is limited by its dependence on the subjectiveself-report of patients. Physiological… more
Abstract:DESCRIPTION (provided by applicant): Mortality from colorectal cancer (CRC) can be reduced through screening programs. Regardless of the primary strategy (fecal occult blood testing, sigmoidoscopy, colonoscopy, fecal DNA, computed tomographic colonography[virtual colonoscopy]) colonoscopy is… more
Abstract:DESCRIPTION (provided by applicant): Tobacco use is the leading cause of cancer death. While daily tobacco consumption in the United States has declined to 18.1%,1, 2 nondaily smoking (smoking on some days but not every day) is increasing,3 particularly among young adults.2 Yet, nondaily smokers are… more
Abstract:DESCRIPTION (provided by applicant): Adherence with prostate cancer screening (such as PSA tests, and physician follow-ups), is less than perfect. In large part, this is because members of at-risk populations need to keep track of which tests are requiredand at what time. As screening guidelines and… more
Abstract:DESCRIPTION (provided by applicant): Of the 24 million patients diagnosed with diabetes in the US, 6.5 million (27%) depend on a strict regime of insulin administration. Limited or unreliable patient reporting of critical diabetes care parameters (blood glucose measurements, carbohydrate intake, and… more
Abstract:DESCRIPTION (provided by applicant): Postmenopausal osteoporosis is a more dangerous disease than previously thought and is one of the most common diseases in older women. One in two women over age 50 will have an osteoporosis-related fracture during their lives, and fractures in postmenopausal… more
Abstract:DESCRIPTION (provided by applicant): This Fast-Track SBIR application submitted by SimpleC of Atlanta, Georgia, requests funds to test our current behavior management technology for persons with dementia (PWD), the SimpleC Companion, and to develop and test a new mobile tablet, the SimpleC Wellness… more
Abstract:DESCRIPTION (provided by applicant): The objective of this research application is the development of a simple, highly portable test system for rapid screening for human immunodeficiency virus (HIV) and hepatitis at the point of care (POC). This test system will be capable of identifying patients… more
Abstract:DESCRIPTION (provided by applicant): Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer. The lesions are typically surgically removed. However, there is a risk of recurrence as another DCIS or as a more dangerous invasive cancer. If the DCIS is large, full mastectomy is used,… more
Abstract:DESCRIPTION (provided by applicant): After an interim period of inactivity based on a select alternative commercial focus, and after consultation with the FDA, Neoprobe Corporation is rapidly reinitiating efforts to develop and commercialize 125Iodine-labeled HuCC49 CH2 anti-Tumor Associated… more
Abstract:DESCRIPTION (provided by applicant): According to the American Cancer Societylt s 2009 report, one in eight women will develop breast cancer in her lifetime. Early detection of breast cancer through periodic screening using x-ray mammography has been highly effective in lowering mortality-rates.… more
Abstract:DESCRIPTION (provided by applicant): According to the Centers for Disease Control and Prevention, cigarette smoking causes the vast majority of lung cancers and over 400,000 deaths annually with a total monetary cost exceeding 190 billion. While the majority of the 45+ million US smokers want to… more
Abstract:DESCRIPTION (provided by applicant): Preservation of functioning renal parenchyma is important and nephron-sparing surgery substitutes for radical nephrectomy in appropriately selected patients with renal cell carcinoma. Laparoscopic partial nephrectomy (LPN) has demonstrated excellent outcomes in… more
Abstract:DESCRIPTION (provided by applicant): Dramatic increases in the incidence of obesity, diabetes, and the metabolic syndrome are increasing the prevalence of chronic liver diseases. Liver fibrosis arising from an excessive deposition of type I collagen in theparenchyma, occurs in advanced stages of… more
Abstract:DESCRIPTION (provided by applicant): A pocket-sized device for personal exposure level assessment Abstract Detecting environmental toxicants is critical for better understanding of the relationship between chemical exposures and many diseases, and for more effective prevention of the related… more
Abstract:DESCRIPTION (provided by applicant): The ultimate goal of this program is to enable a new generation of high performance, low cost ophthalmic Optical Coherence Tomography OCT technology based on new MEMS-tunable vertical cavity surface-emitting laser (MEMS-VCSEL) swept light sources. This will be… more
Abstract:DESCRIPTION: Synthetic Biology is full of promises ranging from discovery and production of new drugs, targeted therapies modifying organisms such as yeast or E. coli or creating totally new ones, higher crop yields, CO2 sequestration to bio-energy projects. However, these goals have been difficult… more
Abstract:DESCRIPTION (provided by applicant): Diagnosis of preterm labor is the most difficult and important task facing medical practitioners in maternity care today. Knowing when labor has begun as well as predicting when it will start is important for both normal and complicated pregnancies. Presently,… more
Abstract:The goal of this project is to develop a mobile, smartphone/tablet-based neurocognitive assessment that will provide a multifactoral (i.e., neural, physiological, performance) evaluation of cognitive functioning associated with impaired driving due to stimulant or depressant usage. The Mobile… more
Abstract:Aminoglycosides are an important class of antibiotics for the treatment of aerobic, gram-negative bacteria (Pseudomonas, Acinetobacter, Enterobacter) and mycobacteria (Mycobacterium tuberculosis, M. avium), causes of serious co-infections in HIV-infected persons. Widespread use of aminoglycosides… more
Abstract:This solicited Phase II proposal builds on L-Nutra s successful Phase I results which identified a dietary formulation (Chemolieve) that protects mice against the toxicity of chemotherapy drugs and retards the growth of cancer masses while enhancing the efficacy of chemotherapy. The proposed Phase… more
Abstract:The overarching goal of this project is to develop and commercialize a nanotechnology-based diagnostic platform capable of monitoring tumor microenvironments in vivo. Specifically, PKC will develop a biosensor based on carbon nanotube transistor technologies for monitoring levels of vascular… more
Abstract:Conventional methods of performing dietary self-assessments are cumbersome. In addition they yield inaccurate data which is one of the biggest barriers to understanding the way diet is related to diseases. The proliferation of smartphones and tablets provides an opportunity to conveniently and… more
Abstract:Tumor Paints for real-time intraoperative visualization of solid tumors enable more complete resection while sparing surrounding normal tissue. For brain tumors this is of paramount importance, since removal of additional tissue can unnecessarily increasecognitive and functional impairment. The… more
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