Abstract:This solicited Phase II proposal builds on L-Nutra s successful Phase I results which identified a dietary formulation (Chemolieve) that protects mice against the toxicity of chemotherapy drugs and retards the growth of cancer masses while enhancing the efficacy of chemotherapy. The proposed Phase… more
Abstract:The overarching goal of this project is to develop and commercialize a nanotechnology-based diagnostic platform capable of monitoring tumor microenvironments in vivo. Specifically, PKC will develop a biosensor based on carbon nanotube transistor technologies for monitoring levels of vascular… more
Abstract:Conventional methods of performing dietary self-assessments are cumbersome. In addition they yield inaccurate data which is one of the biggest barriers to understanding the way diet is related to diseases. The proliferation of smartphones and tablets provides an opportunity to conveniently and… more
Abstract:Tumor Paints for real-time intraoperative visualization of solid tumors enable more complete resection while sparing surrounding normal tissue. For brain tumors this is of paramount importance, since removal of additional tissue can unnecessarily increasecognitive and functional impairment. The… more
Abstract:Historically, tissue sample analysis was limited due to lack of practical high throughput techniques. An advance in tissue analysis came with the invention of the multitumor tissue block. This technology was improved upon, refined and eventually evolvedinto the Tissue Microarray (TMA), currently a… more
Abstract:Following ablative surgery for thyroid cancer, follow-up management of patients includes monitoring for radioiodine uptake or serum TG levels. Recombinant human thyroid stimulating hormone (rhTSH) is currently used to increase the sensitivity of measurements in patients on thyroid hormone … more
Abstract:This technology introduces a new non-invasive, biopsy-adjunct with a MNP platform for targeted tumor delivery. It employs closely sized magnetic nanoparticles (CS-MNP's) for determining their concentration and spatial distribution in tumor vasculatures asmeasured by magnetic resonance imaging… more
Abstract:Surgical resection of malignant tumors is the single most effective therapy for cancer. Long-term patient outcomes are strongly determined by the extent to which the surgeon can completely remove all diseased tissues. Present cancer imaging and detectionmethods often fail to provide a clear… more
Abstract:TP-0413 is a novel small molecule inhibitor of the BMP pathway that has significant potential to be developed to treat anemia of cancer. Anemia of cancer is cytokine driven and results in the up-regulation of a liver hormone called hepcidin through the function of BMP receptors. Increased hepcidin… more
Abstract:Cancer is a leading cause of death that affects millions of lives across the world. It is a complex disease that is likely to require multifactorial measurements for earlier and more accurate diagnosis and patient stratification. Tissue biopsies and fine needle aspirates are commonly collected… more
Abstract:The Hsp90 inhibitor 17-DMAG will be encapsulated in a nano-sized liposome formulation that is long-circulating with controlled drug release properties in tumor tissue. Reformulation of 17-DMAG in a nanoliposome will increase the dose intensity of 17-DMAG in solid tumors while reducing the hepatic,… more
Abstract:This project aims to develop a stabilized epothilone B (Epo B)-loaded micelle for the intravenous delivery of Epo B to solid tumors. The data should demonstrate that Epo B is encapsulated within the micelle with weight-loadings in the range of 1-5% wt/wt Epo B. Crosslinking chemistries will be… more
Abstract:The aim of this project is to reformulate a highly lipophilic anti-cancer agent, valrubicin (AD-32) that has only been approved for vesicular treatment of bladder cancer due to its poor dose limiting toxicities due to poor water solubility. LipoMedics willreformulate valrubicin (AD-32) utilizing a… more
Abstract:To modify the Contractor's ID-Cap medication adherence system to add biometric identification and secure communication systems that enable compliance improvement programs. Thr result is that it can allow for accurate, real-time monitoring of medication adherence with no effort by the patient.… more
Abstract:We have entered a stage where there are plentiful of therapeutic agents either in clinical use or in development for clinical use. The difficulty is not in finding drugs for treatment, but to tailor fit treatment to the patients- personalized medicine. Personalized medicine demands both… more
Abstract:Cardiovascular disease is a leading cause of morbidity and mortality and both high LDL-C and low HDL-C remain validated factors that predict and contribute to risk. Reliance on the lipid, cholesterol, as the surrogate marker to measure total LDL and HDL has limitations and provides inadequate… more
Abstract:Folic acid is a water-soluble vitamin that serves as a cofactor in 1-carbon transfers required for DNA replication. Humans lack the enzymes to synthesize folate, so dietary intake is necessary. Its deficiency is associated with neural tube defects (NTDs) in fetuses. The global burden of folate… more
Abstract:Breast, cervical, and colorectal cancer can be successfully prevented and/or diagnosed and successfully treated at the earliest stages through use of appropriate and timely screening and adequate follow-up and care coordination. Recognizing the importance of cancer screening, groups like the… more
Abstract:A rapid respond to outbreaks critically depends on laboratory confirmation of suspected measles cases. In general, the turnaround times for serologic test results provided by the WHO Measles/Rubella Laboratory Network are adequate; however, results from specimens collected in remote areas can be… more
Abstract:This SBIR will study the application of a brain machine interface (BMI) to enable crew to remotely operate and monitor robots from inside a flight vehicle, habitat and/or during an extra-vehicular activity (EVA). The goal is to improve robot operator productivity, situational awareness, and… more
Abstract:DESCRIPTION (provided by applicant): Advanced Medical Electronics Corporation (AME) proposes to develop a smartphone-based audiovisual array that enables hearing aid users to converse with multiple speakers in reverberant environments with significant speech babble noise where their hearing aids do… more
Abstract:This project creates an easy to use and unobtrusive hearing aid accessory that solves a very common problem for hearing aid users: understanding speech in noisy environments. A common problem amongst hearing aid users is trouble understanding speech while listening to a conversation in environments… more
Abstract:DESCRIPTION (provided by applicant): Alzheimer's disease (AD) is the leading cause of dementia and the early stage of the disease is characterized by forgetfulness and trouble with remembering words and names. AD is the leading cause of dementia and the sixth leading cause of death in the… more
Abstract:DESCRIPTION (provided by applicant): This proposed project aims to develop technology that facilitates care of infants that are typically in transition from a neonatal intensive care unit (NICU). The focus of this technology is to monitor the conditions associated with chronic lung disease of… more
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