Abstract:Historically, tissue sample analysis was limited due to lack of practical high throughput techniques. An advance in tissue analysis came with the invention of the multitumor tissue block. This technology was improved upon, refined and eventually evolvedinto the Tissue Microarray (TMA), currently a… more
Abstract:Following ablative surgery for thyroid cancer, follow-up management of patients includes monitoring for radioiodine uptake or serum TG levels. Recombinant human thyroid stimulating hormone (rhTSH) is currently used to increase the sensitivity of measurements in patients on thyroid hormone … more
Abstract:This technology introduces a new non-invasive, biopsy-adjunct with a MNP platform for targeted tumor delivery. It employs closely sized magnetic nanoparticles (CS-MNP's) for determining their concentration and spatial distribution in tumor vasculatures asmeasured by magnetic resonance imaging… more
Abstract:Surgical resection of malignant tumors is the single most effective therapy for cancer. Long-term patient outcomes are strongly determined by the extent to which the surgeon can completely remove all diseased tissues. Present cancer imaging and detectionmethods often fail to provide a clear… more
Abstract:TP-0413 is a novel small molecule inhibitor of the BMP pathway that has significant potential to be developed to treat anemia of cancer. Anemia of cancer is cytokine driven and results in the up-regulation of a liver hormone called hepcidin through the function of BMP receptors. Increased hepcidin… more
Abstract:Cancer is a leading cause of death that affects millions of lives across the world. It is a complex disease that is likely to require multifactorial measurements for earlier and more accurate diagnosis and patient stratification. Tissue biopsies and fine needle aspirates are commonly collected… more
Abstract:The Hsp90 inhibitor 17-DMAG will be encapsulated in a nano-sized liposome formulation that is long-circulating with controlled drug release properties in tumor tissue. Reformulation of 17-DMAG in a nanoliposome will increase the dose intensity of 17-DMAG in solid tumors while reducing the hepatic,… more
Abstract:This project aims to develop a stabilized epothilone B (Epo B)-loaded micelle for the intravenous delivery of Epo B to solid tumors. The data should demonstrate that Epo B is encapsulated within the micelle with weight-loadings in the range of 1-5% wt/wt Epo B. Crosslinking chemistries will be… more
Abstract:The aim of this project is to reformulate a highly lipophilic anti-cancer agent, valrubicin (AD-32) that has only been approved for vesicular treatment of bladder cancer due to its poor dose limiting toxicities due to poor water solubility. LipoMedics willreformulate valrubicin (AD-32) utilizing a… more
Abstract:To modify the Contractor's ID-Cap medication adherence system to add biometric identification and secure communication systems that enable compliance improvement programs. Thr result is that it can allow for accurate, real-time monitoring of medication adherence with no effort by the patient.… more
Abstract:We have entered a stage where there are plentiful of therapeutic agents either in clinical use or in development for clinical use. The difficulty is not in finding drugs for treatment, but to tailor fit treatment to the patients- personalized medicine. Personalized medicine demands both… more
Abstract:Cardiovascular disease is a leading cause of morbidity and mortality and both high LDL-C and low HDL-C remain validated factors that predict and contribute to risk. Reliance on the lipid, cholesterol, as the surrogate marker to measure total LDL and HDL has limitations and provides inadequate… more
Abstract:Folic acid is a water-soluble vitamin that serves as a cofactor in 1-carbon transfers required for DNA replication. Humans lack the enzymes to synthesize folate, so dietary intake is necessary. Its deficiency is associated with neural tube defects (NTDs) in fetuses. The global burden of folate… more
Abstract:Breast, cervical, and colorectal cancer can be successfully prevented and/or diagnosed and successfully treated at the earliest stages through use of appropriate and timely screening and adequate follow-up and care coordination. Recognizing the importance of cancer screening, groups like the… more
Abstract:A rapid respond to outbreaks critically depends on laboratory confirmation of suspected measles cases. In general, the turnaround times for serologic test results provided by the WHO Measles/Rubella Laboratory Network are adequate; however, results from specimens collected in remote areas can be… more
Abstract:DESCRIPTION (provided by applicant): Strain background can strongly influence the outcome of toxicity tests in animals. Time and cost constraints preclude in vivo approaches to longstanding concerns about the lack of genetic diversity in animal models. Anin vitro platform is vastly more efficient… more
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