Abstract:At present, trains use various dissipative braking systems to slow and stop, and this significant braking energy is ultimately converted to heat and wasted. APEI, Inc. has proposed a hybrid tender which can capture and reuse a significant fraction of this braking energy (at least 50%). The hybrid… more
Abstract:There are a number of critical telemetry measurements to be monitored under continuous field operation, including temperature data across the reactor chamber and the nozzle, pressure data, neutron flux density and flow rate of the propellant. Real-time monitoring of this data in nuclear thermal… more
Abstract:In this project, APEI, Inc. will design and develop a high performance, high voltage SiC MCPM that is low cost, manufacturable, reliable and reworkable. The target utility scale energy storage applications include power conversion systems for grid-tie, solar array, wind turbine, and vehicle-to-grid… more
Abstract:ABSTRACT: To significantly reduce procurement overhead and recognizing the mission strategic importance of developing modular power electronics for interfacing the battery to the spacecraft bus, APEI, Inc. is proposing to develop a novel multi-module, inherently scalable, high power density,… more
Abstract:APEI, Inc."s Phase II goal is to develop, fabricate and test a compact, high temperature, high performance isolated gate drivers utilizing HTSOI integrated circuits, discrete SiC devices, and high frequency coreless magnetics. Additionally, leveraging its existing high performance high… more
Abstract:Increasing electrification of the modern military ground vehicle fleet places ever-increasing demand on each vehicle"s electric power generation and distribution systems. The quantity of instrumentation, computing, and electronic weaponry countermeasures systems is rapidly growing, as is their… more
Abstract:DESCRIPTION (provided by applicant): Type II Mucopolysaccharidosis (MPS), also known as Hunter's syndrome, is a genetic disease that affects the lysosomal enzyme, iduronate-2-sulfatase (IDS). Consequently, patients with MPS-II develop extensive lysosomal storage product accumulation in tissues,… more
Abstract:DESCRIPTION (provided by applicant): Tumor necrosis factor (TNF)- plays a pro-inflammatory role in brain diseases. The biologic TNF inhibitors (TNFI), such as the TNF decoy receptor cannot be developed for brain diseases, because the TNFIs are large molecules that do not cross the blood-brain… more
Abstract:DESCRIPTION (provided by applicant): Metachromatic leukodystrophy (MLD) is an genetic disease caused by mutations in the gene encoding the lysosomal enzyme, arylsulfatase A (ASA). Symptoms including neurodegeneration and mental retardation appear during infancy or childhood; and early death can… more
Abstract:ABSTRACT: ArmorWorks will develop an airman"s personal power distribution system that employs inductively coupled power transfer at connection nodes to portable electronic equipment. The system reduces battery logistic burdens created by the use of airman mounted electronic devices and will… more
Abstract:It is no longer sufficient to design and build single mission vessels, large or small. In today"s world, vessels need to be multi-functional and adaptable to changing world conditions and scenarios. Art Anderson Associates has developed a concept design for a multi-mission capable, amphibious… more
Abstract:DESCRIPTION (provided by applicant): Dehydration is a frequent cause of morbidity and mortality in the elderly. Identifying at risk individuals and maintaining adequate fluid balance is an essential component of health care in the aging population. Currently, there is no effective tool available… more
Abstract:DESCRIPTION (provided by applicant): Umbilical cord blood (UCB) provides unique advantages over bone marrow (BM) and mobilized peripheral blood (MPB) as a source of hematopoietic stem cells (HSCs) for transplants, as it allows use of partially HLA-matchedunits without increasing GvHD incidence.… more
Abstract:This effort proposes to design, build, and demonstrate a new instrument for icing research and flight safety capable of discriminating liquid water from ice while simultaneously measuring the diameter, velocity, and temperature of droplets or the velocity and size for ice crystals. From these… more
Abstract:This proposal address innovations to the Laser-Induced Incandescence method aimed at (1) improving the lower detection limit of soot volume fraction by as much as two orders of magnitude and increasing overall measurement range by two orders of magnitude to meet new regulation that are in place or… more
Abstract:ABSTRACT: Development of advanced multi-angle illumination and multi-dimensional image correlation strategies set forth in this proposal will be instrumental in revealing and gaining a better understanding of the complexities of fuel injection, spray formation and spray dynamics associated with… more
Abstract:DESCRIPTION (provided by applicant): The overall goal of the proposed research is to develop orally active inhibitors of myeloperoxidase MPO as a treatment forAlzheimer's disease. MPO is an abundant enzyme in leukocytes but its expression can be induced inastrocytes in Alzheimer's disease.… more
Abstract:ABSTRACT: This phase I project will develop and merge the different technologies to reduce the defect-density of mid-bandgap (1.4 eV) chalcopyrite based solar absorbers to enable>15% efficient modules (at standard test conditions) on lightweight and flexible polymer substrates. As an added… more
Abstract:Among thermal control methods, variable-emittance materials remain the most promising for addressing deficiencies of current systems (mechanical louvers, loop heat pipes, MEMS, electrostatics, phase change materials, others), especially, e.g., for missions in extreme light/dark environments,… more
Abstract:ABSTRACT: Advanced Li battery technology remains beset with performance deficiencies at low/high temperatures/extreme environments (high vacuum, radiation, vibration/shock), primarily from poor conductivity/mobility in organic electrolytes used under such conditions. In this respect, electrolytes… more
Abstract:A new, very inexpensive, lightweight (25 mg/cm^2), low power (micro-W/cm^2), electrochemical voltammetric sensor technology for CW agents, based on unique conducting polymer microporous membranes and ionic liquid electrolytes with very wide operating temperature, is offered. Voltammetric sensing… more
Abstract:This Small Business Innovation Research Phase I project will develop a fiber optically coupled in situ probe utilizing a superluminescent diode (SLD) optical source for monitoring bioreactor fermentations with ASL?s bioreactor monitor. The current ASL monitor uses a conventional, thermal light… more
Abstract:Aspen Systems Inc. proposes a novel personal cooling system that uses a vapor compression chiller to circulate cooled water through flow channels in a wearable vest to facilitate improved cooling of personnel in high-temperature environments. The system is designed to cycle coolant delivered to… more
Abstract:High power microwave (HPM) sources have been developed over the past few decades for many important DoD missions ranging from electronic warfare to intentional EMI to impulse radar. One important area of development for HPM devices is ballistic missile defense (BMD). HPM systems and techniques may… more
Abstract:Since there is no clear final configuration, ASR has chosen to contemplate a design concept to be accomplished during a potential Phase II award along with a Phase I work plan to demonstrate feasibility of the Phase II concept. ASR proposes to develop an HPM source for deployment into the MLRS M26… more
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