Abstract:DESCRIPTION (provided by applicant): Mirna Therapeutics, a Texas-based company, is developing non-small cell lung cancer (NSCLC) therapies using tumor suppressor miRNAs. This approach, miRNA replacement therapy , is based on the concept that re-introduction of miRNAs depleted in cancer cells… more
Abstract:Aircraft Flight Operations Quality Assurance (FOQA) programs are implemented by most of the aircraft operators. Vast amounts of FOQA data are distributed between many computers, organizations, and geographic locations. This project develops methodology for transforming such distributed data into… more
Abstract:DESCRIPTION (provided by applicant). Several leading authorities, including the World Health Organization (WHO) and the U.S. Department of Health and Human Services (DHHS), have identified asthma as a priority disease area, and have called for action to reduce chronic disability and premature death… more
Abstract:DESCRIPTION (provided by applicant): Researchers and contractors are under increasing pressure to produce rapid turnaround times for data releases and publications. Inadequate data management is a common threat to good research and impedes the quick release of high value data. Despite its importance… more
Abstract:Low pressure filtration and dewatering techniques for solid-liquid separation (SLS) of particulate material from dilute streams are of great importance in reducing the cost and energy consumption of processing materials in wide variety of food, water, pharmaceutical and energy related industries. … more
Abstract:DESCRIPTION (provided by applicant): Each year in the US, approximately 600,000 total knee replacement (TKR) surgeries are performed at a total annual cost of 15B and nearly 4.5M Americans are currently living with a TKR implant. The survival rate of TKRdevices declines dramatically after ten years… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will establish proof of concept for enhancing fungal bioinsecticide to control bark beetles, important forestry pests. Although research shows potential of fungal insect pathogens as bark beetle bioinsecticides, no commercial products… more
Abstract:The proposed Wireless, passive, SAW sensor system operates in a multi-sensor environment with a range in excess of 45 feet. This proposed system offers unique features in two (2) important areas. The first is in the development of a new sensor type, a strain gauge that is based on OFC techniques and… more
Abstract:Mobile Intelligence Corporation (MIC) and Wayne State University propose a virtual teleoperation and visual landmark navigation system for UGV teleoperation in buildings, tunnels and caves. The challenge is search and navigation in complex structures with sparse visual cues, high-latency… more
Abstract:Teleoperation of high speed ground robots is very difficult. People use an enormous amount of proprioceptive cues to estimate safe travel speeds and compensate for motion jitter. Simply moving the controls off-board takes away those cues, and makes the task much harder. Worse, the reality of radio… more
Abstract:In order to provide the highest level Quality of Service (QoS) for both tracking and discrimination functions it is imperative that information from all sensors be associated correctly. Due to potential bandwidth, latency and timeline impacts, it may be necessary to limit downlinked Airborne… more
Abstract:One of the principle challenges in developing a robust missile defense architecture is the characterization and classification of objects in a threat complex. The Ballistic Missile Defense System (BMDS) performance depends on data from diverse EO/IR and RF sensors. The objective of this proposal… more
Abstract:The task of managing employment planning and real time tasking of sensor resources in complex ballistic missile defense target environments demands innovative techniques. As the complexity of a threat scene grows, the resources required to survey the situation grow at an even faster rate. Sensor… more
Abstract:ABSTRACT: As satellite technology has become increasingly pervasive in both our military warfighting capability and civilian society, the ability to determine and forecast space environmental impacts on these satellites is critical. AFRL, NOAA and NASA have been nowcasting and forecasting space… more
Abstract:The proposed Phase II.5 work builds upon previous Phase II work for this SBIR program. MTSI will perform several tasks during the Phase II.5 program to extend the previous work and increase the Technology Readiness Level (TRL) to TRL 5. The previous Phase I and Phase II work applied probabilistic… more
Abstract:Accurate assessment of burn size, depth and the compromise of normal tissue physiology, as well as the tracking of wound response, is essential for successful treatment of burns and one of the major problems that face clinicians and surgeons. The primary method of burn wound assessment is subjective… more
Abstract:DESCRIPTION (provided by applicant): Diabetes mellitus affected 285 million adults worldwide in 2010 and is expected to increase in prevalence to 439 million people by the year 2030. Foot ulceration continues to be a major comorbidity of diabetes and afflicts as many as 15 to 25% of subjects with… more
Abstract:ABSTRACT: We propose to develop an assured information sharing framework for cloud-based systems that leverages our ongoing work in the areas of policy-based usage management and semantic interoperability. The development of this framework will involve the creation of a novel approach to… more
Abstract:Modus Operandi proposes to develop Inception, a collaborative intelligent wiki for searching, gathering, interpreting, validating, capturing and documenting the characterization of stakeholder needs for Modeling and Simulation systems. The first phase or the inception phase of the systems… more
Abstract:ABSTRACT: A nightmare scenario for the U.S. Air Force is where multiple satellites suddenly stop communicating without warning, indicating a possible hostile anti-satellite campaign on the nation"s space assets. In order to mitigate this significant national risk, the Air Force Space Command… more
Abstract:Navy operators are being inundated with intelligence information, especially text. Better methods and tools are needed to help them identify the mission-relevant"needles"within these information"haystacks."Researchers have made progress using ontologiesrepresented as RDF… more
Abstract:Modus Operandi proposes the development of the Semantic Targeting and All-source Fusion Framework (STAFF), an innovative, net-centric framework for fusing human intelligence (HUMINT), video and imagery intelligence (IMINT), signals intelligence (SIGINT), and other intelligence data for high-value… more
Abstract:Early identification of indicators or behaviors of adversarial intent is critical to protecting US soldiers from attack during counter-insurgency and peace-keeping missions. Furthermore, the enemy goes to great lengths to hide his activities, making detection even more difficult. Modus Operandi… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project is directed towards the development of an ultrahigh speed micro-spindle for micro-machining. The proposed spindle for micro-milling and micro-grinding at speeds near 500,000 rpm will be implemented with existing commercial… more
Abstract:ABSTRACT: The overall objective and scope of this proposed effort includes determining bearing requirements for a high performance 1000 lbf thrust class gas turbine engine; a review of materials suitable for extreme environment bearings; preliminary trade studies to assess thrust bearing design;… more
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