Abstract:DESCRIPTION (provided by applicant): The overall goal for this SHIFT SBIR application is to develop new, easy-to-use conjugatable adjuvant lipid vesicle (CALV) kits which contain Toll-like Receptor (TLR) agonists 3 and 7/8. Utilizing our proprietary VesiVax(R) CALV system and the Bacillus anthracis… more
Abstract:DESCRIPTION (provided by applicant): The overall goal of this SBIR AT application is to develop a multi-adjuvant liposomal vaccine formulation that targets dendritic cells and can be applied to our current vaccine programs. The innovation is a dual adjuvant system where VesiVax(R) lipid vesicles are… more
Abstract:DESCRIPTION (provided by applicant): A kit based PET agent: edotreotide Ga 68 for clinical imaging of somatostatin receptor expressing tissue. Synthetic peptides targeted to Somatostatin receptors (SSTR) were developed almost 30 years ago by Novartis to inhibit the effects of endogenous growth… more
Abstract:DESCRIPTION (provided by applicant): We propose to develop a software package to automatically evaluate a subject's beta amyloid PET scan (using either C11-PIB, F18-florbetaben, or F18-florbetapir, F18-flutemetamol) by normalizing the subject's scan, masking away non-gray matter tissue… more
Abstract:DESCRIPTION (provided by applicant): According to the NIAID fact sheet on Botulism, the extreme toxicity of botulinum neurotoxins (BoNT) and the ease of production, transport, and delivery make this an agent of extreme bioterrorism concern. Nonetheless, although there are major vaccine… more
Abstract:DESCRIPTION (provided by applicant): Although a rapid and accurate diagnosis is crucial to the management of patients suspected of bacterial infection, the currently available radiopharmaceuticals are not capable of distinguishing between sterile inflammation and bacterial infections. Our goal is to… more
Abstract:DESCRIPTION (provided by applicant): Using conservative criteria it is estimated that 7 percent of the population in North America and 7-10 percent worldwide have Irritable Bowel Syndrome (IBS), a relapsing functional bowel disorder with unclear etiology.Disabling symptoms of IBS account for a… more
Abstract:Resodyn Corporation is proposing a material and application system that will create a low friction coating on concrete median barriers. The advanced material developed for the low friction coating is an affordable, tough, weather resistant, and environmentally friendly copolymer. The proposed… more
Abstract:ABSTRACT: The current polyurethane based coatings on the landing skis/skids of US Air Force aircraft require frequent maintenance due to exposure to extreme conditions. A long-lasting, low-friction, hydrophobic, impact and abrasion resistant coating on the landing ski/skids is highly desired to… more
Abstract:The U.S. Navy seeks an in-situ powder coating material and application method for spot repair. Resodyn Corporation proposes a unique restoration and repair polymer thermal spray coating (R & RPTS) system that provides the ease of repair, safety in handling, and effective coating protection to… more
Abstract:Electromagnetic grid structures buried in optical ceramic domes may be accurately located using an electromagnetic sensing and detection techniques. Under the Phase I effort, Resodyn Corporation developed a sensor and detection technology that demonstrated position location to within 1 mil is… more
Abstract:DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase I project will develop and demonstrate a broad-application prototype Artificial Accessory Cell that can be used as a supplement and/or replacement for cytokines for the directed differentiation of stem cells into… more
Abstract:DESCRIPTION (provided by applicant): NeuroPlay Adventures addresses the need to develop innovative neuroscience educational tools to benefit children in kindergarten through 12th grade (K-12). The goals of this project are: (1) to develop mobile apps for tablets and smart phones and a web-site that… more
Abstract:The proposed innovation is an automated UAS mission planning system that will rapidly identify emergency (contingency) landing sites, manage contingency routing, and dynamically evaluate route changes for viability and safe operations in the NAS. Specifically, RAMPS will feature a pre-flight… more
Abstract:NASA's System Oriented Runway Management (SORM) project is studying operational concepts and algorithms to improve the efficiency and capacity of metroplex operations, where performance is measured not only at the runways but across the airport surface and metroplex airspace. Current SORM… more
Abstract:Growing concern over global climatic and environmental changes and our urgent need to quantify track and understand their impact on our planet¿s atmosphere, oceans, and land surfaces have prompted the development of extremely sensitive and technologically sophisticated instruments. To meet the… more
Abstract:High performance infrared detectors in the LWIR regime are highly needed in a number of missile defense missions. In order to image targets from long distance, it is important that imagers have high sensitivity and high resolution. This leads to technical goals of having low noise, low dark current… more
Abstract:Infrared countermeasure and standoff chemical detection applications require a light source with high power output, good beam quality, and a wide tuning range. There are a limited number of viable mid-infrared (3-5 micron wavelength) solutions that can provide these features in a compact and power… more
Abstract:Recent development of Antimonide-based Type-II superlattice infrared detectors has resulted in significant breakthroughs in terms of device performance as well as FPA imaging quality. Improvement in material quality and processing technique, as well as evolutionary modifications in device… more
Abstract:MSP is introducing in this proposal a practical approach to a family of cascade impactors capable of real-time measurement of the size-distributed mass concentration of particles in the atmosphere. Further, because of the high sensitivity of the proposed mass transducers, these impactors will also… more
Abstract:Multiform Harvest Inc. ("Multiform") produces the fertilizer struvite, which is magnesium ammonium phosphate hexahydrate. Multiform produces the struvite by extracting it from wastewaters containing excess phosphorus. Multiform sells into two markets: 1) wastewater generators who need to… more
Abstract:Munro offer an innovatiive, intelligent, fully integrated hardware and software cockpit system solution for handling many General Aviation (GA) and UAV emergencies so as to minimize NextGen ATM disruption while saving lives. This ADS-B-ER system will provide GA airplanes and UAVs automated -ER… more
Abstract:S-Band vacuum loads at the SLAC linac are encountering operational problems, now that they have to operate under the stringent requirements of the LCLS: 50 MW peak power, 6 kW average power, and extremely-tight phase stability for the linac. Failure mechanisms have been studied which suggest an RF… more
Abstract:Advanced beam diagnostics are essential for high performance accelerator beam production and for reliable accelerator operation. It is important to have noninvasive diagnostics which can be used continuously with intense beams of accelerated particles. Recently, an electron probe was tested to… more
Abstract:The objective of lab-on-chip (LOC) is to integrate and perform multiple analytical processes on a microchip platform. So far, most LOC research has been focused on electrophoretic separations. Limited progress has been made on multi-process integration, due mainly to the lack of a robust and… more
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