Abstract:DESCRIPTION (provided by applicant): Over 8 million Americans have peripheral vascular disease (PAD). Percutaneous transluminal artery (PTA) treatment of severe PAD involves the use of balloons and stents, but delivery of these therapies is often suboptimal due to inaccuracies in angiographic… more
Abstract:DESCRIPTION (provided by applicant): Transseptal (TS) access for left heart procedures is an important and rapidly growing space for diagnostics and therapy delivery with an expected total of over 10 million U.S. patients. In the U.S. and/or Europe, TS access procedures are used for atrial… more
Abstract:DESCRIPTION (provided by applicant): Coronary artery disease (CAD) is a national and worldwide epidemic that places the largest clinical and economic burden on the healthcare system of any disease condition. Patients with stable and acute coronary conditions are often treated with percutaneous… more
Abstract:DESCRIPTION (provided by applicant): A critical need currently exists in the pharmaceutical market for microparticles that can accurately and effectively control the release of poorly water-soluble compounds. Although these poorly water-soluble drugs areprojected to have high clinical efficacy,… more
Abstract:DESCRIPTION (provided by applicant): The SHARE Program: Supporting Health, Activities, Resources, and Education is a seven-session early stage intervention for care dyads (the IWD and a family CG) that takes advantage of a time when the IWD can still discuss the diagnosis and plan for the future.… more
Abstract:NASA requires new instrumentation technologies that can be applied to measure dynamic quantities such as acceleration and flow velocity under extreme temperatures where traditional sensing methodologies cannot be applied. The proposed Phase I SBIR research effort will seek to create accelerometers… more
Abstract:This Small Business Innovation Research Phase I project will develop nanocomposite capacitor films with high energy density and low loss through the use of a unique synthesis process for high aspect ratio nanowires of previously unrealized compositions in this form. High power capacitors are a… more
Abstract:Spectral beam combination (SBC) of fiber lasers is the most practical approach to DEW-class HELs using diode-pumped fiber lasers. Use of conventional diffraction gratings to combine wavelengths is limited in that metal is inherently absorbing. Regardless of the metal layer thickness, optical power… more
Abstract:Conventional generation of a high-quality RF carrier (signal) beyond 50GHz requires high precision cavity engineering that inherently restricts contiguous bandwidth coverage. Worse, even if one were capable of fabricating a set of such stabilized, frequency-dense cavities to mimic discrete 30-120GHz… more
Abstract:ABSTRACT: In contrast to the NIR band, which is supported by an infrastructure of devices developed to serve telecommunication applications, the SWIR band remains out of reach for critical defense and commercial applications. While it is relatively simple to construct a low-noise oscillator within… more
Abstract:DESCRIPTION (provided by applicant): The overall goal of this phase 2 SBIR proposal is to position our novel biologic GE2 for human clinical trials in allergic disease though the completion of critical preclinical development research activities. GE2, a genetically engineered human fusion protein… more
Abstract:Discovery of frozen volatiles at the lunar poles is transformative to space exploration. In-situ resources will provide fuel to support far-reaching exploration and enable commercial endeavors. While satellite data supports presence of polar ice, driving and drilling must confirm presence, determine… more
Abstract:ABSTRACT: The Etched Air Taper Combiner as fist proposed by the US Air Force Academy has the advantages in that the input fiber bundle, the combining section, and the output to the gain fiber can be individually improved and optimized and then the components are spliced together to create the… more
Abstract:This Small Business Innovation Research Phase I project seeks to develop novel hydrogel drug-delivery systems. We have developed linkers for drug conjugation to circulating macromolecules that release the native drug by beta-eliminative cleavage at predictable rates with half-lives spanning hours to… more
Abstract:ABSTRACT Technological aids supporting medication management for chronically ill patients are proliferating, offered in electronic telehealth devices. Pill organizers, reminders, monitors, and usage communicators have enabled an array of home health aids to support users and caregivers in pill… more
Abstract:Opiate-agonist pharmacotherapy utilizing buprenorphine/naloxone is known to decrease illicit opiate use. However, poor medication management and misuse during self-managed opioid substitution therapy (OST) constrains efficacy, while aggrandizing relapse,hospitalizations and mortality. One of the… more
Abstract:MDA plans to use sensors such as PTSS, SM-3, UEWR, and AN/TPY-2 to track and intercept ballistic missiles. In order to be successful, the C2BMC element must: 1) achieve and maintain stereo tracks, 2) perform target characterization, 3) prioritize and assign targets to interceptors, and 4) handover… more
Abstract:ABSTRACT: Over the last twenty years the United States has become dependent on space technology for communications, precision tracking and many other applications. Globalization of the world"s economy, which has also dramatically increased over the past twenty years, has resulted in this same… more
Abstract:One of the primary research objectives for multi-sensor data fusion within the Ballistic Missile Defense System (BMDS) is the development of novel techniques to enable robust target discrimination. While great strides have been made in recent years to advance capabilities through the use of… more
Abstract:Missile Defense Agency (MDA) recently adopted the Phased Adaptive Approach (PAA) to enhance the Ballistic Missile Defense System"s (BMDS) ability to counter emerging threats in the Middle East and Southeast Asia. PAA primarily focuses on fielding new sensor technology (e.g. AN/TPY-2 and PTSS)… more
Abstract:GoGames will be a tablet-based multiplayer role-play game for middle school social studies classrooms and will focus on topics in civics. GoGames is intended to enable more efficient and effective implementation of traditional civics interventions by replacing static paper content and training… more
Abstract:This proposal addresses the challenge of providing weather and climate information to support the operation, management and planning for wind-energy systems. There is a growing need for extended range forecast information as wind power increases its penetration into the grid. Future scenarios on… more
Abstract:ABSTRACT: Future spacecraft could benefit from onboard planning and scheduling autonomy to effectively fulfill their missions. By eliminating the need to wait for the ground, planning decisions can be made faster based on event and status information available onboard. This is especially… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project will develop a novel ion gate membrane with controlled pore size for redox flow battery. Redox flow battery is one of the most promising electric energy storage (EES) technologies. However, the cost of the state-of-the-art (SOA)… more
Abstract:This Small Business Innovation Research Phase I project proposes to develop a highly permeable inorganic membrane for olefin/paraffin separation. Zeolite membranes have a number of advantages over polymer membranes and other inorganic membranes, including greater chemical and mechanical stability,… more
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