Abstract:This Small Business Innovation Research (SBIR) Phase II project proposes to develop and validate a non-invasive, multiplex urine dipstick for clinical diagnosis of Acute Febrile Illness (AFI) caused by polymicrobial infections. The target diseases include leptospirosis, typhoid fever, dengue, as… more
Abstract:Formic acid (FA, CH2O2) is the simplest carboxylic acid. It is mainly used as a preservative and antibacterial agent in livestock feed. A significant fraction of FA is used in the leather-processing, textile and rubber industries and a small fraction of formic acid is used as a cleaning agent… more
Abstract:This Small Business Innovation Research Phase II project will further develop new proprietary cellulolytic Bacillus subtilis strains that can produce high-titer, optically- pure L-lactate in high yields from pretreated lignocellulosic biomass through consolidated bioprocessing (CBP) technology.… more
Abstract:The project team is developing a prototype of a web-based game utilizing the illustrations of chemical elements and science terms created by Simon Basher in his three books, The Periodic Table: Elements with Style!, Chemistry: Getting a Big Reaction!, and Physics: Why Matter Matters! The game will… more
Abstract:This Small Business Innovation Research Phase II project focuses on the design and construction of a medical device that treats ischemic stroke by virtue of breaking-down endovascular occlusions using a proprietary Electro-Fluidic Thrombolysis (EFT) technology. EFT utilizes low energy electrical… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will study the feasibility of using abundant elements in metallization pastes for crystalline silicon solar cells. Currently, silver-based pastes dominate the market because they do not oxidize and can be processed at high temperatures.… more
Abstract:We are proposing a Wirelessly Powered Smart Tag (WiPST) that integrates a miniaturized novel antenna with a high efficiency rectifier circuit. Our proposed design integrates our latest breakthrough developments in highly efficient rectifier design and wireless power transfer unit. We will leverage… more
Abstract:ABSTRACT: During phase I, we successfully designed a low-profile dual-linear polarization UWB (20-50 GHz) phase array antenna design. A key component of our UWB array is that it has a wide angle scan capability that is critical to achieving uninterrupted communication on the move. We showed that it… more
Abstract:There is no capability to rapidly assess the electrical properties of nanofiber films during manufacturing and prepregging process. Continuous monitoring of these films will guide the U.S. nanofiber manufacturing industry in optimizing and increasing the yield rate with proper process optimization… more
Abstract:ABSTRACT: In Phase I, PaneraTech demonstrated feasibility of a Foldable Lightweight Parabolic Antenna (FLPA) that had the minimum required beamwidth and gain to view at least one GPS satellite anywhere on the earth any time of the day. We achieved significantly high gain compared to traditional GPS… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project aims to develop a prototype 3-D imaging sensor for high temperature furnaces used in the glass industry. These furnaces are also used in many other industries, including cement, coke, iron & steel, and pulp & paper industries.… more
Abstract:The innovation in this project comes from the novel call audio analysis techniques that can be used to create a fingerprint of the source of a telephone call. Such fingerprints can reveal valuable information about the call source, including the type of the calling device (landline, Voice-over IP or… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project will support the development and commercialization of Lightwave Photonics, Inc.?s novel light emitting diode (LED) technology for use in solid-state lighting. Adoption of LED solid-state lighting is still constrained by the prohibitive… more
Abstract:The use of concentrating optics to reduce the area of photovoltaic cells needed in solar power modules has the potential to reduce overall system costs, making solar energy less expensive and speeding its widespread adoption as a cost-effective and sustainable power source. An ideal… more
Abstract:Ocean wave energy has the potential to support approximately 10% of domestic and global electricity demand. Despite considerable investment over the past decade, however, wave energy is unlikely to make a material contribution to domestic or global energy supplies unless new technologies with… more
Abstract:The web-based game, Numbershire II, will include modules to support students with or at-risk for disabilities in learning 2nd grade level mathematics, as defined by Common Core State Standards, including fluency with place value ideas, foundations of multiplication, and procedural fluency with… more
Abstract:DESCRIPTION (provided by applicant): The overall goal of this project is to continue development and commercialization of a Balance Sensory Augmentation and Substitution System (B-SASS). The device termed Walkasins measures foot pressure through a thin sole insert, developed under recent Phase I… more
Abstract:DESCRIPTION (provided by applicant): Tuberculosis (TB) disease, which results from infection with Mycobacterium tuberculosis (Mtb), is a leading cause of infectious morbidity and mortality in children lt 5 years old worldwide. In TB endemic regions, in which the vast majority of the world's… more
Abstract:DESCRIPTION (provided by applicant): Avatar is developing HIV vaccine immunogens based on dityrosine (DT) crosslinking of soluble, native, Env gp140 trimers. Several of the most potent broadly neutralizing Abs ( bnAbs ) preferentially bind native Env trimers, and a trimeric immunogen thus would… more
Abstract:DESCRIPTION (provided by applicant): We are developing a novel immunomodulatory approach to arrest pancreatic islet injury and restore specific immune tolerance in new-onset Type 1 diabetes mellitus (T1D). Damage of pancreatic islets in T1D may result fromexcess pathogenic Th1/Th17 cells and… more
Abstract:DESCRIPTION (provided by applicant): We are developing a novel small molecule cytoprotective drug (R-100) for the prevention of contrast- induced nephropathy (CIN) following IV radiocontrast media (CM) injection. R-100 is a novel cell- permeable redox-active agent formed from the covalent fusion of… more
Abstract:DESCRIPTION (provided by applicant): Radikal Therapeutics is developing a novel small molecule therapy (R-801) for neonatal prematurity that triggers an endogenous cytoprotective defense and thereby blocks pulmonary inflammation and acute lung injury (ALI). R-801 is formed from the covalent fusion… more
Abstract:DESCRIPTION (provided by applicant): Radikal Therapeutics (RTX) is developing a novel cytoprotective agent (R-801) for the prevention of ischemia-reperfusion injury (IRI) following lung transplantation (LTX). In rodent models of severe redox injury, R-801profoundly reduces organ dysfunction, tissue… more
Abstract:DESCRIPTION (provided by applicant): High volume mechanical ventilation (MV) induces a lethal pulmonary complication, termed ventilator induced lung injury (VILI), via the generation of toxic free radical and oxidant species that damage the alveolocapillary membrane, trigger pro-inflammatory gene… more
Abstract:DESCRIPTION (provided by applicant): Radikal Therapeutics (RTX) is developing a novel pharmaceutical therapy for prematurity that targets a developmental deficiency in thioredoxin (Trx), a protein that serves as a central regulator of cellular reductant status. Trx is expressed t levels in the fetal… more
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