Abstract:DESCRIPTION (provided by applicant): NexImmune is developing nanoparticles that stimulate immune responses against cancer and other diseases. This Artificial Immune Modulating (AIM(R)) platform is comprised of an artificial matrix to which various antigen-presenting and immune modulating proteins… more
Abstract:DESCRIPTION (provided by applicant): More than 100,000 patients worldwide have some form of permanently implanted neural interface in the brain. Although effective, these interfaces have several technical limitations that limit the full scope of their clinical efficacy. For severa decades, silicon… more
Abstract:The innovation of network forecasting is a new approach to securing industrial control networks that is based upon 1) discovering, monitoring, and modeling all devices on a network, 2) using these models to predict future device behavior, 3) evaluating past predictions with current observations of… more
Abstract:DESCRIPTION (provided by applicant): Despite remarkable advances in cancer detection and treatment, the disease continues to be a leading cause of mortality in the US accounting for 23% of all deaths in 2011. Cancer of the breast and prostate are by far the most common forms diagnosed in US women… more
Abstract:DESCRIPTION (provided by applicant): Chronic obstructive pulmonary disease (COPD) is a highly and increasingly prevalent disorder characterized by incomplete reversible airflow limitations. It is presently the third leading cause of death in the US, with over 13 million peopl suffering from the… more
Abstract:DESCRIPTION (provided by applicant): Heart failure following a myocardial infarction (MI) continues to remain a leading killer in the western world. In the United States, the estimated annual incidence of myocardial infarction (MI) is 745,000 new and 410,000 recurrent episodes. There is a critical… more
Abstract:DESCRIPTION (provided by applicant): Accurate measurement of core body temperature during surgery as well as in critical care is imperative to a positive outcome and ongoing quality of life for patients. Core temperature management of patients during extended anesthesia such as cardio-pulmonary… more
Abstract:The goal of this application is to synthesize heparan sulfate (HS) library consisting of structurally homogeneous oligosaccharides, in response to a SBIR contract call from NCI- 321 Chemically Defined Glycan Libraries . Glycan Therapeutics is a company specializing in the synthesis of structurally… more
Abstract:DESCRIPTION (provided by applicant): For most Americans, understanding and planning a healthy daily menu can be a confusing and multi- faceted process. The cognitive challenges faced by people with intellectual disabilities (ID) create even greater barriers in understanding the complexity of… more
Abstract:Breast cancer is the most common cancer type among women. Approximately one in every eight women is diagnosed with breast cancer at some time in their life and 30% to 40% of the women who get breast cancer die. Early and accurate detection is viewed asthe best method to decrease breast cancer… more
Abstract:The current emphasis in fish nutrition is fish meal replacement with a variety of alternative protein sources including plant-based, terrestrial and marine proteins. We propose to focus specifically upon the protein quality of these alternate protein sources and its potential impacts on marine fish… more
Abstract:DESCRIPTION (provided by applicant): We propose a novel and competitive urinary tract silicone Foley catheter made from a proprietary polymeric formulation to effectively reduce catheter-associated urinary tract infections (CAUTI) via nitric oxide (NO) release. Preliminary studies show that the… more
Abstract:DESCRIPTION (provided by applicant): We propose a novel and price competitive Tunneled Dialysis Catheter (TDC) made from a proprietary polymeric formulation to effectively reduce TDC dysfunction via long-term nitric oxide (NO) release, particularly duringthe period of AVF maturation in incident… more
Abstract:Transit Agency Information required for managing Service centers on resources and assets that need to be available to operate the transit service as designed. An opportunity exists to design an Integrated Framework providing Service delivery and Maintenance Management Information to quantify the… more
Abstract:Secure trusted biometric validation of identity has never been more important. The increase in global terrorism, unfettered identity theft and new legislation requiring multi-factor authentication are a few of the driving factors. The biometrics industry has not actively responded to the changing… more
Abstract:Consumable submarine and ship subsystem components are often costly to replace and require impractically long procurement cycles. These factors can result in loss of weapon system availability and thus decrease mission readiness. The Kinetic Metallization (KM) process offers the opportunity to… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will investigate the application of a novel tissue engineering approach to the fabrication of animal products, in particular leather. The approach relies on the automated deposition of conveniently prepared multicellular units into a… more
Abstract:Evaluation of the Antigenicity of Black-Restricted Haplotypes of Factor VIII ABSTRACT About 30% of congenital Hemophilia A (HA) patients develop alloantibodies that neutralize the activity of replacement Factor (F) VIII proteins. Such patients, who are termed inhibitor patients, are typically… more
Abstract:DESCRIPTION (provided by applicant): Feasibility of a nerve imaging agent to reduce neurological complications of prostatectomies A key challenge in radical or nerve-sparing prostatectomies is to minimize the neurological complications that can lead to impotence in about 10%-30% of cases and… more
Abstract:Robots need to know their location to map of their surroundings but without global positioning data they need a map to identify their surroundings and estimate their location. Simultaneous localization and mapping (SLAM) solves these dual problems at once. SLAM does not depend on any kind of… more
Abstract:Cryogenic propellants are important to NASA's missions. Improvements in cryogenic propellant storage and transfer are critical to future long duration NASA spacecraft and missions. Advanced Cooled Shield - IMLI (ACS-IMLI) is an innovative ultra high performance system in which an Advanced… more
Abstract:Solar Electric Propulsion drives down the cost of space missions by using its high propulsion efficiency to step down from one launch class to another. As launch costs can be up to a third of total mission costs, stepping down to a smaller rocket can be a mission enabling technology in today's… more
Abstract:An eye-safe, multispectral cross-track scan subsystem with a large receiver aperture and a narrow FOV is proposed for the NASA Cloud Physics Lidar to increase horizontal area coverage. The +/-15 degree cross-track scan capability will cover +/- 5 km from nadir at a 20 km altitude. The cross-track… more
Abstract:NASA has numerous missions that involve radar and radiometry. In the past, the practice has been to build each system as a one-off program, which makes MMIC design unattractive from a cost perspective. In an era of reduced budgets and the need for higher efficiencies both in R & D cost reduction… more
Abstract:A new detector evaluation method (DEM) is proposed to determine the response of graphene detectors to low fluxes of photons, neutral atoms/molecules, and ions in the space environment of high to ultra-high vacuum. The method, aimed mainly at evaluation for space applications of new graphene… more
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