Abstract:DESCRIPTION (provided by applicant): Middle Peak Medical (MPM) is developing a novel percutaneous transcatheter technology, the MPM Mitral Leaflet Repair System, to eliminate mitral regurgitation (MR) caused by degeneration of the posterior leaflet. The System consists of the Coaptation Mesh (CM, an… more
Abstract:DESCRIPTION (provided by applicant): Dry eye (DE) affects 25-30 million people in the U.S. alone and is responsible for 3.84 billion in direct annual health care costs. Evaporative dry eye (EDE) results from a lipid deficiency in tears causing the premature evaporation of tears. The problem to be… more
Abstract:DESCRIPTION (provided by applicant): Finding the signal processing parameter values that are most appropriate for an individual patient is one of the essential components of hearing aid fitting. In common practice, the hearing aid user only plays a small role in selecting these values. This proposal… more
Abstract:DESCRIPTION (provided by applicant): The goal of this project is to develop a dual-mode PET/x-ray mammography scanner (PET/X) to improve the way in which breast cancer therapies are matched to patients by providing early evaluation of therapy efficacy through 'window' studies on an… more
Abstract:DESCRIPTION (provided by applicant): There is no known cure for Osteoarthritis (OA), a debilitating disease that afflicts 27 million people and costs 125 billion, annually. In OA, the articular cartilage is degraded and it has a limited capacity to self-heal; therefore, rendering a diagnosis at a… more
Abstract:DESCRIPTION (provided by applicant): Over 3 million emergency intubations are performed in the US every year and failure rates can be as high as 50% (3-5). Success is highly dependent on how frequently the responder performs this life-saving procedure on humans (6). Brio Device, LLC, an airway… more
Abstract:DESCRIPTION (provided by applicant): Type 1 diabetes often leads to short-term and long-term complications which impair quality of life. Though many research groups are developing versions of an artificial endocrine pancreas (AP) system, current systems require at least one hormone delivery… more
Abstract:Gen9 is developing a DNA synthesis platform that aims to produce synthetic DNA products at an industry leading length, price point and turnaround time. In this proposal we outline our plans to meet the requirements of the solicitation: $0.05per base pair, 7 day order turnaround time and perfect… more
Abstract:DESCRIPTION (provided by applicant): The goal of this project is to develop a DNA synthesizer capable of synthesizing synthetic DNA, called oligonucleotides, a dramatically lower cost than competing technologies. Specifically, we will synthesize oligos ina sample plate that can hold up to 1,536… more
Abstract:DESCRIPTION (provided by applicant): Calista Therapeutics has discovered a first-in-class, proprietary PDZ1-2 lead drug, AT010, that is being optimized and developed as an inhaled daily therapy for cystic fibrosis (CF). CF is a deadly inherited genetic disorder that disrupts chloride channel… more
Abstract:DESCRIPTION (provided by applicant): Orthopaedic Surgical Site Infections (SSIs), including Prosthetic Joint Infections (PJIs), are an extremely costly health care problem, illustrated by the 70,000- 114,000 average total cost per case to treat more than20,000 hip and knee replacement infections… more
Abstract:DESCRIPTION (provided by applicant): Mental health disorders exact very high personal, social and economic costs in our country and around the world, presenting a significant public health challenge. Cogito has developed and deployed technology that listens to natural conversation and produces… more
Abstract:Access to a library of structurally defined N-glycans is an urgent scientific need for glyco-arrays for rapid analysis of carbohydrate binding proteins (CBPs), development of diagnostics and therapeutics for many diseases. However, only a small number ofN-glycans are currently commercially… more
Abstract:Understanding complex system behavior and designing resilient systems is becoming progressively more difficult. Additionally, tools available to visualize interactional behaviors within and surrounding the system of interest are lacking. Therefore, as identified in the OSD SBIR call, there is a… more
Abstract:DESCRIPTION (provided by applicant): The goal of the current project is to elaborate upon, reconstruct and advance to pivotal trial readiness a recently validated Plasticity-based Adaptive Cognitive Remediation program (PACR) for the treatment of HIV-Associated Neurocognitive Disorders (HAND). In… more
Abstract:DESCRIPTION (provided by applicant): Revenue growth and market capitalization of pharmaceutical firms have plunged over the past 10 years. Why? An important factor is that the engine for growth in drug discovery has come to a standstill. Historic relianceon synthetic organic chemistry and more… more
Abstract:This Small Business Innovation Research Phase I project develops sustainable materials for use in injection molding. The technical problem addressed is the development of novel biobased polymer nanocomposites that are suitable for injection molding. The research objective is to exploit a novel… more
Abstract:The innovation in this project is the design and development of a novel Skills- and Assessments-Based Learning Environment (SABLE) to meet the needs of teachers, school districts and parents in helping high school students develop problem-solving skills. Currently, US students' poor performance… more
Abstract:This Small Business Innovation Research (SBIR) Phase 1 project is concerned with photovoltaic (PV) solar technology. Microinverters are presently sold as separate boxes that are bolted either onto the racking or the panel frame and still require DC cables, connectors and the junction box. Partoe?s… more
Abstract:SA Photonics proposes the development of the NeptuneLITE free space optical communication system for aircraft interrogation of sonobuoy fields. NeptuneLIITE enables high data rate (>1 Mb/s) at long range (>40 nautical miles) in a compact form factor with very low cost per sonobuoy.
Abstract:SA Photonics is please to propose the NeptuneLITE free space optical communication system for 3U CubeSat applications. NeptuneLITE allow high data rate communication between sensor satellites, relay satellites, and round terminals. NeptuneLITE will all bi-directional east-east ring communication in… more
Abstract:US and Coalition ground forces depend on armored vehicles for protection from small arms fire, rocket propelled grenades (RPGs) and especially from IEDs during their patrols. Rapid and reliable Battle Damage Assessment and Repair (BDAR) analysis in the field is critical because a vehicle may be… more
Abstract:This proposal develops a new instrument to fully characterize radio-wave interactions in all angles and polarizations at frequencies between 40 and 220 GHz. The instrument's deployment to Department of Defense (DOD) test facilities and to civilian research facilities will accelerate… more
Abstract:From the 19th century until today, we have seen an almost tenfold increase in the ocular injury rate on the battlefield. Injuries to the torso that in the past would have been fatal are now prevented or reduced through use of effective body armor. Although the ocular surface area represents only 0… more
Abstract:ABSTRACT: The ability to maintain precision navigation without periodic position updates from external sensors such as GPS is challenging. One particularly challenging scenario is navigation for transonic through hypersonic weapon systems and UAVs. The flight dynamics and operational environment of… more
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