Abstract:ABSTRACT: In today"s limited government budget environment, the push is towards smaller spacecraft with more rapid development times (<24 months) than traditional systems, which are averaging 48-60 month development timelines. Our team has been a proponent of small satellites and… more
Abstract:ABSTRACT: Scientic, Inc. will team with Vanderbilt University to produce innovative new vacuum field emission (VFE) devices developed from Vanderbilt proprietary laterally configured VFE triode configurations. As a prototype demonstration device, Scientic and Vanderbilt will develop a novel low… more
Abstract:ABSTRACT: C9 Proposes to Develop a high Temperature Heating Element to Augment the Wind Tunnel at AEDC. The element will be fabricated by molding a creamic composite molding compound using methods developed for other defense and commercial applications. The element will be capable of surface… more
Abstract:State-of-the-art software protection and anti-tamper systems move critical software and data"out-of-band"to the adversary, by using a hypervisor or on"secure"hardware. Unfortunately, the systems running this software are built using untrusted commercial-off-the-shelf (COTS) parts… more
Abstract:The NASA's PATH mission includes the GeoSTAR satellite that carries aboard a microwave sounder employing an array of 375 microwave antennas with corresponding receivers. Each receiver is tuned to the 180GHz frequency, while the intermediate frequency (IF) reaches 500MHz. The IF signal is… more
Abstract:Modern flight-critical systems include hundreds of thousands to millions of lines of code. The Boeing 777, for instance, includes over 2 million lines of code. Future projects will only feature an increasing amount of source code, mostly written in the C programming language. The only way to… more
Abstract:This Phase I project is relevant to the ultimate goals of this program announcement given the prevalence of the IED which often creates complex burn wounds on the face and skin that often form hypertrophic scars that often contract over time. Burn wound healing is a complex process that includes… more
Abstract:Improvements in body armor, availability of equipment, and decreased patient transport times have dramatically improved Soldiers"survival of combat injuries. Data suggests that future conflicts will require more aggressive wound management at the point of injury to deal with more complex… more
Abstract:The US Department of Energy has a stated goal to increase the energy efficiency of turbines, and one well recognized method of achieving this is through the use of ceramic thermal barrier coatings (TBCs). However, state of the art zirconia-based TBCs have a temperature limit of about 1200oC, and new… more
Abstract:In this SBIR Project MagiCom proposes several innovative concepts to develop a light weight and low power communication system to enable small kill vehicle communications in flight. The proposed Communications Concept will have the lowest possible weight impact on the KV. MagiCom proposes an… more
Abstract:DESCRIPTION: Significant increase in the efficiency and speed of MS-based tissue imaging (IMS) performed at atmospheric conditions using high-resolution mass spectrometer will have a profound impact on method applications to the entire analytical field ofcharacterization of biomarkers in tissues.… more
Abstract:DESCRIPTION (provided by applicant): Koronis Biomedical Technologies (KBT) proposes a novel tool to test the integrity of implantable cardioverter- defibrillator (ICD) leads in-situ. Siilar to pacemakers, ICDs are surgically implanted just under the skin outside of the patient's rib cage. An… more
Abstract:ABSTRACT: The expense in operating legacy aircraft is reduced if the aerodynamic performance can be improved. Many of these aircraft were designed before modern prediction methods and flow controls were available and it is probable that operating costs could be reduced if recent advances were used.… more
Abstract:DESCRIPTION (provided by applicant): This SBIR grant application is in response to PA-11-335, from Lab to Marketplace: Tools for Biomedical and Behavioral Research. The intent of PA-11-335 is to help move useful technologies from non-commercial laboratories into the commercial marketplace by… more
Abstract:DESCRIPTION (provided by applicant): We propose an innovative microtechnology-enhanced surgical device that solves a significant therapeutic bottleneck in the treatment of lens cataract in children. As the leading cause of childhood blindness, lens cataract interferes with the optical performance of… more
Abstract:DESCRIPTION (provided by applicant): This project aims to generate blood tests for: 1. mild cognitive impairment (MCI), and 2. conversion risk from MCI to full-blown Alzheimer's disease (AD). We have reported that systemic footprints, increases in key micro- RNA (miR) levels, are identifiable… more
Abstract:DESCRIPTION (provided by applicant): This Phase IIB SBIR application is responsive to NHLBI RFA HL-13-016, NHLBI SBIR Phase IIB Bridge Awards to Accelerate the Commercialization of Technologies for Heart, Lung, Blood and Sleep Disorders and Diseases (R44) . This RFA solicits work on basic,… more
Abstract:DESCRIPTION (provided by applicant): This application, Imaging Software of Functional Connectivity MRI for Alzheimer's Disease , is written in response to (PA-11-134) Lab to Marketplace: Tools for Brain and Behavioral Research (SBIR [R43/R44]) . Alzheimer's disease (AD) is the most… more
Abstract:DESCRIPTION (provided by applicant): The long-term goal of this project is to identify and validate biomarkers of mitochondrial dysfunction due to environmental stressors. Diverse acute insults from surgery, trauma, ischemia/reperfusion (I/R) and drug andenvironmental chemical toxicity lead to… more
Abstract:DESCRIPTION (provided by applicant): This Phase II SBIR application proposes the development and testing of a theory-based health promotion mobile phone application, BodiMojo, for adolescents (ages 13-18). The product is designed to: (1) promote wellness,healthy eating and physical activity in… more
Abstract:Whole blood remains the cornerstone specimen type used in molecular analysis. Changes in the DNA, RNA, protein, peptide, metabolic, and blood cell analyte levels during pre-analytic specimen handling between collection and eventual molecular analysis impacts testing accuracy and delegitimizes any… more
Abstract:DESCRIPTION (provided by applicant): Minimal Residual Disease Monitoring by T-cell Receptor Repertoire Profiling T-cell neoplasms are generally more aggressive and have poorer outcomes than comparable B-cell lymphomas. In addition, for many of these patients, prognosis following disease relapse is… more
Abstract:DESCRIPTION (provided by applicant): Many patients requiring stem cell transplantation for hematological malignancies are unable to find a suitable HLA-matched sibling or unrelated donor. Transplants using stem cells from umbilical cord blood provide an alternative for these patients, allowing… more
Abstract:Immunotherapy has emerged as a promising method to treat several cancers. In 2012 the FDA approved a new immunotherapy agent, ipilimumab, for metastatic melanoma. Ipilimumab activates T-cells and globally increases the adaptive immune response and resultsin an enhanced response to the cancer. In a… more
Abstract:DESCRIPTION (provided by applicant): The goal of this Phase I SBIR is the pre-clinical development of a novel gene-based delivery system for bevacizumab (anti-VEGF antibody) to treat wet age-related macular degeneration (AMD). The premise is based on: (1)the demonstrated efficacy of monthly… more
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