Abstract:DESCRIPTION (provided by applicant): Minimal Residual Disease Monitoring by T-cell Receptor Repertoire Profiling T-cell neoplasms are generally more aggressive and have poorer outcomes than comparable B-cell lymphomas. In addition, for many of these patients, prognosis following disease relapse is… more
Abstract:DESCRIPTION (provided by applicant): Many patients requiring stem cell transplantation for hematological malignancies are unable to find a suitable HLA-matched sibling or unrelated donor. Transplants using stem cells from umbilical cord blood provide an alternative for these patients, allowing… more
Abstract:Immunotherapy has emerged as a promising method to treat several cancers. In 2012 the FDA approved a new immunotherapy agent, ipilimumab, for metastatic melanoma. Ipilimumab activates T-cells and globally increases the adaptive immune response and resultsin an enhanced response to the cancer. In a… more
Abstract:DESCRIPTION (provided by applicant): The goal of this Phase I SBIR is the pre-clinical development of a novel gene-based delivery system for bevacizumab (anti-VEGF antibody) to treat wet age-related macular degeneration (AMD). The premise is based on: (1)the demonstrated efficacy of monthly… more
Abstract:Technology focusing on collection, processing, and analysis of real-time data is playing a major role in military and civilian applications. With the advent of GPU and accelerator computing, the collection, processing, and analysis of real-time data streams is technically possible at an… more
Abstract:DESCRIPTION (provided by applicant): Project Summary We propose to develop a non-invasive method to predict mammalian oocyte quality by analyzing the surrounding cumulus cells' gene expression patterns (cGEP). The result of the cGEP assay---a cGEP score---can be used to predict embryo quality… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project aims to develop inexpensive carbon dioxide sensors for heating, ventilation and air conditioning (HVAC) controls. CO2 sensors are now being used to lower heating bills and improve air quality in new commercial buildings, but they have… more
Abstract:Foundational studies of desktop-bound technical computing users, referred to as the missing-middle of the high performance computing (HPC) market, have identified the lack of simple software, limited access to technical talent, and difficulty in estimating the return on investment (ROI) as critical… more
Abstract:Nimbis in partnership with UCLA and Smart Manufacturing Leadership Coalition (SMLC) will provide an open workflow environment that supports the sequential execution of 3rd party APPS using net-worked information based modeling and data analytic technologies to integrate manufacturing intelligence… more
Abstract:Develop an inexpensive, easy to use, aerosolized delivery system of a combination of anti-tubercular drugs that could be used for the treatment of multi-drug resistant tuberculosis (MDR TB ). PUBLIC HEALTH RELEVANCE
Abstract:DESCRIPTION (provided by applicant): Goals: The goal is to expand the known pharmacological relationships among arrestin and G protein biased ligands. Starting with the Gi-coupled dopamine D2 receptor (D2R), we will predict biased ligands, evaluatingour methods both retrospectively and via… more
Abstract:DESCRIPTION (provided by applicant): Bioactive small molecules can act on multiple targets, and these off-target activities underlie many of the adverse reactions from which drugs suffer. The motivating idea of this proposal is that these Adverse Drug Reaction (ADR) targets may be predicted… more
Abstract:DESCRIPTION (provided by applicant): The detection and diagnosis of fractures in teeth is a difficult but very common clinical problem that has been specifically identified as a top research priority by the American Association of Endodontists Foundation.Currently, dentists use patient history,… more
Abstract:This Small Business Innovation Research Program (SBIR) Phase I project will focus on the design, construction, and verification of a terahertz (THz) hydration mapping system for use in paper manufacturing. THz radiation is defined as the submillimeter region of the electromagnetic spectrum, and is a… more
Abstract:DESCRIPTION (provided by applicant): Rogers Sciences' mission is to provide effective, low morbidity and cost-effective cancer care through the development and commercialization of therapeutic systems based on Continuous Low Irradiance Photodynamic Therapy (CLIPT). The initial application and… more
Abstract:DESCRIPTION (provided by applicant): The most common malignancy in American women is breast cancer. Breast reconstruction for mastectomy currently involves two choices, implant or autologous tissue flap. Implant reconstruction is relatively simpler but istemporary, whereas flap reconstruction is… more
Abstract:This project will develop SciSkillQuest, a web-based multiplayer game intended to teach middle school students scientific inquiry skills and to foster academic growth mindsets in science. Students will pursue quests, employing inquiry skills to navigate and succeed in the game, including Questioning… more
Abstract:ABSTRACT: Investing in innovation that moves toward the widespread use of satellite autonomy has the potential to yield significant benefits to the space situational awareness (SSA) community. Most notably, if satellite platforms have the ability to detect and respond to events without exchanging… more
Abstract:ABSTRACT: This program develops a Modular Propulsion system design and demonstration test bed that continues the efforts of the Phase I program that established the feasibility of a green propellant based modular propulsion system. Two reduced toxicity propellants will be considered: LMP-103S and… more
Abstract:ABSTRACT: Incorporating hosted payloads onto satellites deployed for other primary missions is an approach that has the potential to provide benefits to both the hosted payload user community and the host satellite providers. But getting rides to space and accommodation on a dedicated satellite bus… more
Abstract:ABSTRACT: The Air Force has identified the need to improve satellite communications by increasing bandwidth, yet seeks to accomplish this without increasing the antenna payload footprint and without introducing vulnerability to transmission interference or jamming. One mature and popular… more
Abstract:NASA's future X-ray astronomy missions will require X-ray optics that have large effective areas, are lightweight, and cost effective. Recent X-ray telescopes, such as the Chandra Observatory, utilized reflectors made from zerodur which were up to 20mm thick. The thickness of the reflector as… more
Abstract:The project team is developing a prototype of InfoWriter, a Web 2.0 concept mapping tool and writing environment to support students in writing informational and explanatory texts. The product will be used in middle and high school English Language Arts classrooms, and others as appropriate, to… more
Abstract:Substitution of standard military tires for low rolling resistance tires have yielded 7% fuel costs savings on Army demonstrator vehicles. However, tire changes to improve rolling resistance affect other areas of tire performance. A tire is a composite structure made up of different rubber… more
Abstract:The ability of soldiers to determine the locations of other personnel within their vicinity based upon line-of-bearing estimates of radio transmissions is of great importance to the army. The relative positions of both friends and foe within the area of operations provides great tactical advantages… more
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