Abstract:This Small Business Innovation Research Program (SBIR) Phase I project is focused on the development of a scalable high performance state of the art computational software platform for simulation of the quasi-static ion optics devices and motion dynamics of many (more than 1 million) charged… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project will demonstrate a prototype frequency tunable quantum cascade laser (TQCL) operating at terahertz frequencies (2-5 THz) for applications including gas spectroscopy and non-destructive imaging. This novel source is based on distributed… more
Abstract:DESCRIPTION (provided by applicant): Koronis Biomedical Technologies (KBT) proposes a novel tool to test the integrity of implantable cardioverter- defibrillator (ICD) leads in-situ. Siilar to pacemakers, ICDs are surgically implanted just under the skin outside of the patient's rib cage. An… more
Abstract:ABSTRACT: The expense in operating legacy aircraft is reduced if the aerodynamic performance can be improved. Many of these aircraft were designed before modern prediction methods and flow controls were available and it is probable that operating costs could be reduced if recent advances were used.… more
Abstract:DESCRIPTION (provided by applicant): This SBIR grant application is in response to PA-11-335, from Lab to Marketplace: Tools for Biomedical and Behavioral Research. The intent of PA-11-335 is to help move useful technologies from non-commercial laboratories into the commercial marketplace by… more
Abstract:DESCRIPTION (provided by applicant): We propose an innovative microtechnology-enhanced surgical device that solves a significant therapeutic bottleneck in the treatment of lens cataract in children. As the leading cause of childhood blindness, lens cataract interferes with the optical performance of… more
Abstract:DESCRIPTION (provided by applicant): This project aims to generate blood tests for: 1. mild cognitive impairment (MCI), and 2. conversion risk from MCI to full-blown Alzheimer's disease (AD). We have reported that systemic footprints, increases in key micro- RNA (miR) levels, are identifiable… more
Abstract:DESCRIPTION (provided by applicant): This Phase IIB SBIR application is responsive to NHLBI RFA HL-13-016, NHLBI SBIR Phase IIB Bridge Awards to Accelerate the Commercialization of Technologies for Heart, Lung, Blood and Sleep Disorders and Diseases (R44) . This RFA solicits work on basic,… more
Abstract:DESCRIPTION (provided by applicant): This application, Imaging Software of Functional Connectivity MRI for Alzheimer's Disease , is written in response to (PA-11-134) Lab to Marketplace: Tools for Brain and Behavioral Research (SBIR [R43/R44]) . Alzheimer's disease (AD) is the most… more
Abstract:DESCRIPTION (provided by applicant): The long-term goal of this project is to identify and validate biomarkers of mitochondrial dysfunction due to environmental stressors. Diverse acute insults from surgery, trauma, ischemia/reperfusion (I/R) and drug andenvironmental chemical toxicity lead to… more
Abstract:DESCRIPTION (provided by applicant): This Phase II SBIR application proposes the development and testing of a theory-based health promotion mobile phone application, BodiMojo, for adolescents (ages 13-18). The product is designed to: (1) promote wellness,healthy eating and physical activity in… more
Abstract:Whole blood remains the cornerstone specimen type used in molecular analysis. Changes in the DNA, RNA, protein, peptide, metabolic, and blood cell analyte levels during pre-analytic specimen handling between collection and eventual molecular analysis impacts testing accuracy and delegitimizes any… more
Abstract:DESCRIPTION (provided by applicant): Minimal Residual Disease Monitoring by T-cell Receptor Repertoire Profiling T-cell neoplasms are generally more aggressive and have poorer outcomes than comparable B-cell lymphomas. In addition, for many of these patients, prognosis following disease relapse is… more
Abstract:DESCRIPTION (provided by applicant): Many patients requiring stem cell transplantation for hematological malignancies are unable to find a suitable HLA-matched sibling or unrelated donor. Transplants using stem cells from umbilical cord blood provide an alternative for these patients, allowing… more
Abstract:Immunotherapy has emerged as a promising method to treat several cancers. In 2012 the FDA approved a new immunotherapy agent, ipilimumab, for metastatic melanoma. Ipilimumab activates T-cells and globally increases the adaptive immune response and resultsin an enhanced response to the cancer. In a… more
Abstract:DESCRIPTION (provided by applicant): The goal of this Phase I SBIR is the pre-clinical development of a novel gene-based delivery system for bevacizumab (anti-VEGF antibody) to treat wet age-related macular degeneration (AMD). The premise is based on: (1)the demonstrated efficacy of monthly… more
Abstract:Technology focusing on collection, processing, and analysis of real-time data is playing a major role in military and civilian applications. With the advent of GPU and accelerator computing, the collection, processing, and analysis of real-time data streams is technically possible at an… more
Abstract:DESCRIPTION (provided by applicant): Project Summary We propose to develop a non-invasive method to predict mammalian oocyte quality by analyzing the surrounding cumulus cells' gene expression patterns (cGEP). The result of the cGEP assay---a cGEP score---can be used to predict embryo quality… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project aims to develop inexpensive carbon dioxide sensors for heating, ventilation and air conditioning (HVAC) controls. CO2 sensors are now being used to lower heating bills and improve air quality in new commercial buildings, but they have… more
Abstract:Foundational studies of desktop-bound technical computing users, referred to as the missing-middle of the high performance computing (HPC) market, have identified the lack of simple software, limited access to technical talent, and difficulty in estimating the return on investment (ROI) as critical… more
Abstract:Nimbis in partnership with UCLA and Smart Manufacturing Leadership Coalition (SMLC) will provide an open workflow environment that supports the sequential execution of 3rd party APPS using net-worked information based modeling and data analytic technologies to integrate manufacturing intelligence… more
Abstract:Develop an inexpensive, easy to use, aerosolized delivery system of a combination of anti-tubercular drugs that could be used for the treatment of multi-drug resistant tuberculosis (MDR TB ). PUBLIC HEALTH RELEVANCE
Abstract:DESCRIPTION (provided by applicant): Goals: The goal is to expand the known pharmacological relationships among arrestin and G protein biased ligands. Starting with the Gi-coupled dopamine D2 receptor (D2R), we will predict biased ligands, evaluatingour methods both retrospectively and via… more
Abstract:DESCRIPTION (provided by applicant): Bioactive small molecules can act on multiple targets, and these off-target activities underlie many of the adverse reactions from which drugs suffer. The motivating idea of this proposal is that these Adverse Drug Reaction (ADR) targets may be predicted… more
Abstract:DESCRIPTION (provided by applicant): The detection and diagnosis of fractures in teeth is a difficult but very common clinical problem that has been specifically identified as a top research priority by the American Association of Endodontists Foundation.Currently, dentists use patient history,… more
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