Abstract:It is extremely important to understand the temporal characteristics of electron beams at accelerator photoinjectors. Measuring and setting the electron bunchlength is critical to the operation of the accelerator, and can ultimately determine if physics experiments at user-based accelerators can be… more
Abstract:DESCRIPTION (provided by applicant): Chronic gingival inflammation of the soft tissue surrounding the tooth afflicts over half of all American adults. In the most severely affected, progression of this inflammatory process to the deeper periodontal ligaments and alveolar bone results in tooth loss… more
Abstract:DESCRIPTION: Glycans have several distinct properties that make them excellent targets for disease biomarkers. Firstly, the location of the glycans on the cell surface makes them the first point of contact of cellular interactions and thus crucial in thecontrol of normal metabolic processes. Cell… more
Abstract:FPGAs are widely used in nearly every DoD electronics system because of their processing capabilities, low NRE costs, field programmability, and time to market advantages over ASICs. However, FPGAs"greatest strength reconfigurability is also the source of their low performance and high power… more
Abstract:To enable NASA's next-generation missions, there is a critical need for a reconfigurable FPGA that can withstand the wide temperatures ranges and radiation of the space environment while consuming minimal power without compromising on performance. To address this need, GoofyFoot Labs proposes… more
Abstract:DESCRIPTION (provided by applicant): Acute kidney injury (AKI) is common, expensive, and highly morbid. There are currently no therapies for AKI, and prevention and treatment represents a 6.3 billion market opportunity annually in the U.S. Moreover, patients are developing AKI more frequently and… more
Abstract:DESCRIPTION (provided by applicant): Myelosuppression continues to represent the major dose-limiting toxicity of cancer chemotherapy, resulting in considerable morbidity and mortality along with frequent reductions in chemotherapy dose intensity, which maycompromise disease control and survival.… more
Abstract:ABSTRACT: We propose a novel SWIR/MWIR imaging system targeted for deployment at geosynchronous orbits. The new system is based on interferometric principles, is scalable, light-weight, and uses easily replicable inexpensive optics. The optics, detectors, and interferometric signal processing… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to develop a topical formulation incorporating a polymeric platform that releases therapeutic levels of nitric oxide gas, and assess its efficacy in dispersing wound-relevant bacterial biofilms. The intellectual merit of the… more
Abstract:Three dimensional (3D) imaging and single-wavelength active sensors are very effective for distinguishing moving targets, such as missiles, from decoys and for cutting through natural clutter and thermal noise. For systems equipped with ALS to accurately acquire, track and point moving objects,… more
Abstract:DESCRIPTION (provided by applicant): Animal models of disease are transforming preclinical research, allowing critical insights into disease mechanisms and evaluation of new therapeutics. While the utility and availability of animal models in research isswiftly expanding often the research tools… more
Abstract:ABSTRACT: Ground Surveillance Radar (GSR) is a fundamental and proven component of Department of Defense"s (DoD) Battlefield Awareness. Advanced radar systems on large remotely piloted aircraft (RPAs) include Synthetic Aperture Radar (SAR) and Ground Moving Target Indicators (GMTI). The… more
Abstract:DESCRIPTION (provided by applicant): Inhibikase Therapeutics is a clinical stage, biopharmaceutical company that has developed a host- targeted mechanism of action to treat AIDS-related and drug-induced progressive multifocal leukoencephalopathy (PML). PMLis a demyelinating disease of the central… more
Abstract:The proposed work seeks to clearly demonstrate the advantage of the multiple-input multiple-output (MIMO) radar architecture over a similar single-input multiple-output (SIMO) or phased array system; the benefit of applying data-adaptive signal processing techniques in favor of their… more
Abstract:As part of an effort funded by HEL-JTO, we recently demonstrated advanced quantum well diode laser designs with enhanced confinement operating at 1500 nm that substantially advanced the state-of-the-art with regard to efficiency, high operating temperature and beam quality. Similar enhanced… more
Abstract:DESCRIPTION (provided by applicant): Acute kidney injury (AKI) is a common, severe complication of cardiopulmonary bypass (CPB) assisted surgeries, and include coronary artery bypass grafts, valve replacements, aortic aneurisms, and organ transplants. Elderly patients, diabetics, and chronic kidney… more
Abstract:DESCRIPTION (provided by applicant): Patients with infective endocarditis (IE) have a poor prognosis with one third of the patients succumbing to the infection within the first year. Treatments for endocarditis involve antibiotic therapy and/or surgery that cost upwards of 100,000 per patient;… more
Abstract:Throughout the past decade, there has been increasing urgency to develop novel technologies for alternative energy sources. This is being driven by the consequential relationships of increased global consumption, rapidly diminishing fossil fuel reserves, growing national energy security concerns,… more
Abstract:DESCRIPTION (provided by applicant): Our long-term goal is to develop a novel therapeutic strategy for childhood acute lymphoblastic leukemia (ALL), with focus on relapsed T-cell leukemia. We intend to accomplish this by targeting a unique molecular masterregulator using a new generation of… more
Abstract:ABSTRACT: The objective of this proposal is to identify and quantify trust metrics for all of the resources in a complex network infrastructure, determine a method for securing communications, and demonstrate the feasibility of our approach to quantify and adopt the end-to-end trust of components… more
Abstract:Pain is subjective and inherently difficult to quantify, yet appropriate pain management is predicated on adequate assessment. Whenever possible, pain is measured by the patient"s self-report. Patients who cannot reliably self-report are at significantly higher risk for inadequately managed… more
Abstract:DESCRIPTION (provided by applicant): Strength and balance training has been demonstrated to prevent physical decline and falls in older adults. The majority of fall prevention studies have focused on supervised group or home-based exercise interventions utilizing qualified personal. The… more
Abstract:DESCRIPTION (provided by applicant): The public health problem addressed by this proposal is that inactivity in individuals with chronic disabilities who use a wheelchair results in signifiant and costly secondary complications, such as pressure ulcers, obesity, diabetes, osteoporosis, and… more
Abstract:Extreme temperature and non-equilibrium processes are both central to DOEs mission of addressing grand challenges in emerging energy and advanced materials; they are also crucial steps in the manufacture of many high value-add industrial products. MDI is advancing the ability to process and study… more
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