Abstract:It is desirable for the standard Intersystem EMC electromagnetic environments that aircraft must operate in and demonstrate survivability of prior to production and deployment to be a single environment that provides both peak and average field level tests at the same time (instead of splitting the… more
Abstract:The quiet operation and high efficiency of fuel cells provide an ideal solution for portable electric power generation for a wide range of military and commercial applications. A compact and efficient fuel processor that provides hydrogen from multiple types of liquid fuels will allow fuel cell… more
Abstract:ABSTRACT: The current designs of telescopes for space borne applications use monolithic glass, beryllium, or silicon-carbide optics. With the existing optical technology, it is increasingly difficult or impossible to meet the new goals and requirements of AF, ORS, and other modern DoD missions. … more
Abstract:Building on the prior standards based work for the Tool Output Integration Framework (TOIF) and KDM - ISO/IEC 19506, this project will bring
together dynamic and static analysis test results from multiple tools into a single solution that will provide a unified platform for security testing… more
Abstract:ABSTRACT: The overall objective of this program is to develop a robust, state-of-the-art, remote data recovery (RDR) system for on-board data acquisition (OBDA) and fuzing systems used during weapon development research programs. The Phase I effort will include supporting a technical start-up… more
Abstract:DESCRIPTION (provided by applicant): Eden Medical proposes to develop a Self-Sealing Therapy Ostomy Pouch (S2TOP) to stop leakage that leads to skin breakdown and trauma for ostomy care patients. The S2TOP will detect leakage, inform the patient, and prevent leakage occurrence providing better… more
Abstract:Eden Park Illumination, Inc. performed research for the development and commercialization of lamps comprising large arrays of microcavity plasmas capable of generating light in the UVB and C wavelength ranges in a slim and flat form factor. UV light is an efficient light source for a number of… more
Abstract:Hybrid-Electric distributed propulsion (HEDP) is becoming widely accepted and new tools will be required for future development. This Phase I SBIR proposal creates a turbo-electric, hybrid electric propulsion system sizing and weight synthesis tool specifically designed for use in an MDAO framework… more
Abstract:Hybrid-Electric distributed propulsion (HEDP) is becoming widely accepted and new tools will be required for future development with validation and demonstrations during ground and eventually flight testing. To monitor the overall HEDP system health in real time, a virtual requirement to flight… more
Abstract:DESCRIPTION (provided by applicant): This is a phase I proposal to determine the feasibility of developing newly discovered fluorinated sulfamoylbenzamide (FSBA) derivatives as therapeutic agents for the treatment of chronic hepatitis B virus (HBV) infection. These molecules have been identified as… more
Abstract:DESCRIPTION (provided by applicant): This is a proposal to implement a novel high throughput assay system to detect inhibitors of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) formation and/or maintenance. HBV cccDNA is essential to the virus life cycle and its elimination during… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project concerns the design and high-throughput and low-cost manufacturing of metal-based miniature gas chromatograph (mGC) sensor structures. The proposed mGC sensor design and manufacturing is unique and offers competitive advantages as… more
Abstract:ABSTRACT: Engineering & Scientific Innovations, Inc. (ESI) has an extensive background in aircraft survivability and vulnerability reduction and has specific experience in the fundamental understanding of the fire suppressant transport phenomena in highly cluttered spaces such as engine… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project proposes the creation of a mixed-criticality Java virtual machine (VM) and native code hypervisor of unprecedented flexibility and capability. Current generation mixed-criticality systems rely on proprietary and expensive operating… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project proposes to develop a novel radio-frequency (RF) sensing method to provide a real-time measurement of black carbon emissions. The feasibility of this concept was demonstrated in Phase I, and engine emissions measurements are targeted in… more
Abstract:We propose developing high energy density, non-toxic, environmentally friendly zinc-water battery system, which can be manufactured in various form factors including flexible cells, based on novel metal hydrated ruthenium (IV) oxide chemistry. The cells are flexible and have a low recharge voltage.… more
Abstract:DESCRIPTION (provided by applicant): DC-SIGN (dendritic cell specific ICAM-3-grabbing non-integrin), a membrane protein of C-type lectin family, is found in high levels on monocyte-derived DCs, some macrophages, and activated B cells. In vivo, DC-SIGN- positive cells were demonstrated in lymph nodes… more
Abstract:DESCRIPTION (provided by applicant): Acinetobacter are strictly aerobic, non-fermentative Gram-negative bacilli that are of major concern in human health, in particular the species Acinetobacter baumannii. They are responsible for clinically important infections that cause a wide variety of maladies… more
Abstract:DESCRIPTION (provided by applicant): We have identified a novel Type IIb prodrug of riluzole, FC-311, which has the potential to revolutionize therapy for the treatment of the devastating condition of metastatic melanoma acting via a novel glutamatergic mechanism of action, and also be useful to… more
Abstract:It is extremely important to understand the temporal characteristics of electron beams at accelerator photoinjectors. Measuring and setting the electron bunchlength is critical to the operation of the accelerator, and can ultimately determine if physics experiments at user-based accelerators can be… more
Abstract:DESCRIPTION: Plant-derived secondary metabolites have proven to be a rich source of pharmaceuticals. From 1981 to 2010, over 65% of the 1355 new chemical entities introduced worldwide were natural products or natural product derivatives. The benzylisoquinoline alkaloids (BIAs) represent a diverse… more
Abstract:This Small Business Innovation Research (SBIR) project aims to engineer microbes for the cost-effective production of specialty chemicals. Currently, engineered microbial strains bear mutations that increase the production of chemicals of interest by inhibiting the cell's ability to produce off… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to produce microbes capable of cost-effective production of amino acids used as animal feed supplements. Technical research herein will test the feasibility of applying cutting edge synthetic biology and metabolic engineering… more
Abstract:DESCRIPTION: Therapeutic peptides are used to treat human diseases ranging from HIV to diabetes and have some of the best features of small molecule and recombinant protein drugs. Therapeutic peptides account for 13 billion of annual pharmaceutical salesand are part of a growing sector of the… more
Abstract:Glycans are directly involved in the pathology of many major diseases. Glycosylated biomolecules are involved in biological functions including cell signaling, cell growth, immunity, three-dimensional protein folding and target interaction. However, medical benefits resulting from glycobiology are… more
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