Abstract:We propose to develope a 64x64 far infrared germanium focal-plane array with the following key design features:1-Four top-illuminated, 32x32 germanium sub-arrays will be tiled together to form a 64x64 mosaic array. Germanium offers very low noise and proven performance in the 50-140?m range.2-The… more
Abstract:Refractory alloys such as tantalum-tungsten and ceramics are being pursued as a solution to high temperature erosive wear of gun barrels. However rifling of these materials with conventional broaching and electrochemical milling is proving to be difficult. This proposal seeks to demonstrate an… more
Abstract:DESCRIPTION (provided by applicant): Retinitis pigmentosa (RP), a hereditary disease of the retina affecting 100,000 Americans, is the major cause of blindness in adults aged 25-60. There is no approved therapy for the disease and gene therapy, while promising, is limited because of the diversity of… more
Abstract:DESCRIPTION (provided by applicant): The osteoporosis market is still in demand for new therapeutics due to the lack of safe orally available bone building drugs. Currently, parathyroid hormone (PTH; FORTEOTM) and its analogs are the only bone building therapies available yet they capture only 8% of… more
Abstract:ABSTRACT: In Phase II, we will fabricate a SQUID array antenna. We will develop cryopackaging and control electronics for these devices. We integrate the device onto a cryocooler and build a laboratory prototype. We will then have all of the building blocks to build a fieldable prototype in Phase… more
Abstract:DESCRIPTION: Biomarkers currently employed for the detection of organ toxicity are often not sensitive enough to detect the early stages of acute organ damage, i.e. at a stage when reducing or eliminating exposure to a toxin could prevent progression of organ damage or a disease process, nor do… more
Abstract:Failures in aircraft electrical power systems can compromise the readiness, safety, and capabilities of the war-fighter. Furthermore, if the root cause for the failure cannot be quickly identified, this can lead to increased maintenance costs and potential downtime for the aircraft. In this effort,… more
Abstract:State-of-the-art electrical starter/generator (ES/G) systems have become increasingly complex in design and integration due to significant power-demand increase in more electric aircraft initiatives such as the Joint Strike Fighter (JSF). They must provide high performance and high efficiency with… more
Abstract:The overall objective of this research project is to investigate autonomous control architectures for spacecraft power systems. Such techniques will be critical for deep space missions that face inhospitable environments, unpredictable operating conditions, and communication delays. The distributed… more
Abstract:The US Army and Marines rely significantly on fossil-fuel based tactical power generation to provide electrical energy to deployed troops in small camps and forward operation bases. These generators are sized to support the expected maximum power but are often operated far below rated power due to… more
Abstract:ABSTRACT: The move towards more-electric aircraft continues to increase the complexity of electrical power systems (EPS) on modern airborne platforms. In addition to ever expanding peak and regenerative power demands, several of the loads can introduce very high rates of current change (dI/dt)… more
Abstract:The movement to more-electric architectures during the past decade in military and commercial airborne systems continues to increase the complexity of designing and specifying the electrical power system. The addition of numerous high-power electric loads has drastically altered the dynamics of… more
Abstract:PCKA has developed a dynamic, real-time thermal capacity algorithm and gauge for predicting current and anticipated fuel heat sink capability on a fifth-generation tactical aircraft. Relevant internal and external sources and sinks are tracked with prognostics and adaptive intelligence designed to… more
Abstract:DESCRIPTION (provided by applicant): The goal of this proposal is to develop tumor necrosis factor (TNF )-inhibiting compounds as neuroprotectant drugs for treating Alzheimer's disease (AD). Current FDA-approved AD interventions are symptomatic treatments with limited efficacy which do not… more
Abstract:ABSTRACT: The overall objective of the proposed SBIR program is to rapidly advance and optimize the manufacturing of dual-use carbon fiber/polyimide matrix composites with high thermo-oxidative stability (TOS) for use in aircraft components with service temperatures exceeding those of PMR-15. This… more
Abstract:A miniature (5 pounds, 10 watts) LWIR multi-spectral/hyperspectral imaging system will be developed for applications in remote detection and identification of chemical and biological warfare agents, toxic industrial chemicals (TIC"s), homemade explosives (HME"s) and disturbed soil… more
Abstract:In today"s world, unmanned vehicles play ever-increasing roles in the military, firefighting, deep-sea and space exploration, and border defense. There is often a one-to-one ratio between operator and these unmanned vehicles; in some systems, an entire team of humans is required to operate a… more
Abstract:Unmanned systems are taking on an increasing role in the U.S. military. Monitoring unmanned vehicles, sensors, and events in dynamic environments is an intense and demanding task. Today"s unmanned systems provide limited support for detecting problems and anomalies, and deliver alerts that are… more
Abstract:Decision making is driven by context. Context can be hard to operationalize and harness to the design of decision support systems. Modern military task displays often omit important context which can lead to singificant errors. This problem is exemplified in undersea warfare and specifically contact… more
Abstract:During Phase II, Pacific Science & Engineering (PSE) developed a composable, standardized display design called a Janus module to support multi-tasking supervision. Janus enables supervisors to scan multiple modules to quickly determine critical issues. Janus was successfully applied to the PEO… more
Abstract:This Small Business Innovation Research Program (SBIR) Phase I project will research autonomous, dynamic power management to reduce power consumption in data center servers by up to 15-20%, strongly supporting the Environmental Protection Agency's push toward low-power data centers and rapid… more
Abstract:DESCRIPTION (provided by applicant): We propose to develop a therapy for neurodegenerative tauopathies that uses a recombinant adeno- associated viral (AAV) vector to achieve long-term, stable central nervous system (CNS) delivery of a therapeutic tau N-terminal antibody (TNT-Ab). To this end, we… more
Abstract:DESCRIPTION (provided by applicant): The overall goal of this project is the preclinical development of a novel Rho kinase inhibitor (TRX-101) as a new therapy for scleroderma/systemic sclerosis (SSc). SSc is a chronic disease of unknown etiology characterized by severe and often progressive… more
Abstract:DESCRIPTION (provided by applicant): Diabetic nephropathy (DN) is the most common cause of end-stage renal disease (ESRD) in the world and affects about 15-25% of type I diabetes patients and 30-40% of patients with type II diabetes. The development of DNis thought to result from the cumulative… more
Abstract:DESCRIPTION (provided by applicant): Iron-overload disorders, including hereditary hemochromatosis, are typically insidious, causing progressive and sometimes irreversible end-organ injury before clinical symptoms develop. Iron overload in vital organs increases the risk for liver disease (cirrhosis… more
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