Abstract:DESCRIPTION (provided by applicant): The goal of this proposal is to develop an effective enzyme replacement therapy (ERT) for Sanfilippo A patients by exploiting safety, supply, and cost advantages of plant-based enzyme bioproduction while integrating novel ERT delivery strategies being development… more
Abstract:EOIR will develop a next generation Cloud Analytics Collaboration Environment using the commercial HTML 5 standard while maintaining compatibility with the existing DOD Cloud Computing architecture to include the Ozone Framework. This will be implemented by a"compose-able"set of… more
Abstract:DESCRIPTION (provided by applicant): The aim of this project is to investigate a simple method for slowing down the rate of electrophoretic translocation of DNA through a nanopore. Unique modulations of current across nanopores produced by individual basesduring such translocation forms the basis of… more
Abstract:The innovation is a new approach to structuring, collecting and using historical geospatial data that will make it possible to rapidly assign a geographic location for text descriptions appearing in historic documents. Geospatial location is a critical element of most documents, and historical… more
Abstract:The goal of this SBIR effort is to develop an autonomous capability that image analysts will utilize to extract useful information from a large volume of data in real time. A key component of this capability is the development of a tool that will fully utilize very large intelligence data streams, e… more
Abstract:Parachutes are a vital technology for moving equipment, ammunition, and other supplies to the battlefield. Cargo parachutes are used to drop military equipment and supplies from aircraft. The U.S. Army currently uses Low Cost Aerial Delivery Systems (LCADS) parachutes for 99% of operational airdrops… more
Abstract:The project team is developing a prototype of a web-based intervention for pre-kindergarten and kindergarten students to prepare for the transition to grade school. The product will support students as they create stories using a step-by-step scripted interactive process. The stories will focus on… more
Abstract:Hall of Heroes will be a web-based game for fifth graders to engage with pedagogical agents (animated life-like characters) to solve tailored social problem solving tasks and build social skills to use in challenging situations. Instructional content will focus on six core Social Skill Units… more
Abstract:This project team will develop a web-based product to engage 11th and 12th grade high school students with HF-ASD in a self-paced online interactive course to learn about the transition to college, learn specific resilience strategies for coping with the transition to college, and to practice… more
Abstract:There is growing interest in computerized systems to increase accessibility of assessments for students with disabilities. Technology offers an ideal platform for implementing Universal Design (UD) principles for assessment to better accommodate student diversity and support broad student… more
Abstract:The innovation addresses problems of data I/O inefficiency and virtualization in High Performance Computing (HPC). Conventional High Performance Computing (HPC) methods are both inefficient and incompatible with virtualization methods commonly used in servers, creating a roadblock to supercomputing… more
Abstract:DESCRIPTION (provided by applicant): Over the past several decades, a large number of evidence-based prevention initiatives for alcohol, tobacco, and other drug (ATOD) use have been rigorously tested and shown to be efficacious. However, despite availability, evidence-based interventions (EBIs) for… more
Abstract:DESCRIPTION (provided by applicant): Early childhood research indicates that school readiness is a key determinant of a successful transition to school. Between 9.5% and 14.2% of young children experience social-emotional problems that negatively impact school-readiness, and nearly half of children… more
Abstract:Small Unmanned Air Systems (SUAS) are being developed for numerous applications, but size and weight constraints severely limit the capability and endurance of such vehicles. Many missions could be extended by landing for certain periods, entering a low-power state, and re-launching as needed,… more
Abstract:Describe the problem or situation being addressed. The DOEs and publics interest in the problem should be clearly stated (typically one to three sentences). RF couplers used in all of the superconducting accelerator user facilities consist of a stainless steel base material (for thermal isolation)… more
Abstract:Statement of the Problem or Situation that is Being Addressed Describe the problem or situation being addressed. The DOEs and publics interest in the problem should be clearly stated (typically one to three sentences). High Energy Physics has a number of superconducting radiofrequency accelerator… more
Abstract:Laser plasma accelerators have the potential to greatly reduce the cost and size of particle accelerators. A breakthrough in the gas profile used to accelerate the particles is required. Alameda Applied Sciences Corporation proposes to increase the repetition rate of our fast valve from 1… more
Abstract:A primary goal of the Department of Energys Isotope Development and Production for Research and Applications Program (Isotope Program) within the Office of Nuclear Physics (NP) is to produce isotopes that are in short supply in the U.S. and of which there exists no or insufficient domestic… more
Abstract:High-current particle accelerators have need for low-impedance bellows connecting accelerating cells and in other areas of the accelerator. Typical techniques to decrease surface impedance are to use shields of superconducting Nb, however, as these shields move they produce particulates that can be… more
Abstract:Current computer systems are dumb automatons; their blind execution of instructions makes them open to attack. Their inability to reason means they don"t consider the larger, constantly changing context outside their immediate inputs. Their nearsightedness is particularly dangerous because, in… more
Abstract:ABSTRACT: 21CT proposes the Classification Labeling of Aggregated Data (CLAD) Phase 2 effort. CLAD supports a"need-to-share"paradigm to aid in historical cyber traffic analysis and cyber target discovery. The alert-to-share capability determines if multiple analysts are continually… more
Abstract:DESCRIPTION (provided by applicant): Obesity is considered the number one health problem in the US and Europe, affecting 10% to 30% of adult populations. Obese individuals are more likely to acquire a variety of secondary diseases including diabetes, heartproblems, immune deficiencies, some types of… more
Abstract:There are a significant number of people in the U.S. whose literacy deficits significantly limit opportunities for written self-expression, including individuals with intellectual disabilities. While this population can offer revealing insights given their unique perspectives, self-expression often… more
Abstract:People with intellectual disability depend a great deal on work for their quality of life. Working in community-based jobs can make substantial differences in income, relationships and self-esteem. Technology has improved opportunities for this population to independently express their career… more
Abstract:DESCRIPTION (provided by applicant): The program outlined in this application has been designed to accelerate the development and commercialization of a Glucagon Mini-Dose Pen to change the paradigm for treatment of moderate hypoglycemia in insulin-using diabetics. This research is directly relevant… more
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