Abstract:DESCRIPTION (provided by applicant): Cochlear implants have restored hearing in thousands of patients over the last two decades. However, because residual hearing is damaged in the process of insertion, this valuable procedure has been restricted to thosepatients with profound or total deafness.… more
Abstract:DESCRIPTION (provided by applicant): Even as the cost and throughput of commercial sequencers has continued to improve over the last 5 years, there is still a need to further reduce sequencing costs, to increase throughput and sequencing accuracy and to reduce the costs associated with sample… more
Abstract:ABSTRACT ST segment myocardial infarction (STEMI) is a serious acute coronary condition that affects 500,000 Americans each year and results in significant U.S. healthcare costs ( 31B/year for acute MI treatment). STEMI mortality directly relates to the extent of the total myocardial injury and even… more
Abstract:DESCRIPTION (provided by applicant): New dosage forms are needed to address the shortcomings of current practice with regard to administration of medications to pediatric populations. Specifically, in the absence of pediatric-specific products - formulations that are both palatable (to ensure… more
Abstract:DESCRIPTION (provided by applicant): Mosquito-borne members of the Flavivirus family include four serotypes of dengue virus (DENV1-4) and West Nile Virus (WNV) and are classified as re-emerging pathogens due to the frequency and severity of recent epidemics. There are an estimated 100 million DENV… more
Abstract:DESCRIPTION (provided by applicant): The proposed project will further develop marketable ELISA and lateral-flow immunoassay diagnostics (LFI) in both monoplexed and multiplexed formats for the NIAID category A, BSL-4 filoviruses, and will drive pre-clinical development and validation for these… more
Abstract:DESCRIPTION (provided by applicant): While organ transplantation is a vital last resort therapy to treat patients with end-organ failure of the lung there is a growing waiting list of patients who are eligible for transplants as the number of suitable donor organs fall far short of the demand for… more
Abstract:Advanced pulsed power capacitors with energy densities of above 10 J/cc and high breakdown strength are required for the military of the future. While polymers such as BOPP and PET offer excellent loss characteristics, their low energy density has led to a search for alternative polymer dielectrics… more
Abstract:NASA requires instrumentation technologies that can be applied to measure flow under extreme temperatures where traditional sensing methodologies cannot be used. The proposed Phase II SBIR research effort will seek to create wall shear sensors that can be applied to measure signals at temperatures… more
Abstract:Conventional generation of a high-quality RF carrier (signal) beyond 50GHz requires high precision cavity engineering that inherently restricts contiguous bandwidth coverage. Worse, even if one were capable of fabricating a set of such stabilized, frequency-dense cavities to mimic discrete 30-120GHz… more
Abstract:Digital equalizers have been the major enablers in RF communications in terms of managing component imperfections and channel impairments. Specifically, the ever increasing processing power of the dedicating computing processors has availed a steady increase in the ability of complex communication… more
Abstract:Spectral beam combination (SBC) of fiber lasers is the most practical approach to DEW-class HELs using diode-pumped fiber lasers. Use of conventional diffraction gratings to combine wavelengths is limited in that metal is inherently absorbing. Regardless of the metal layer thickness, optical power… more
Abstract:ABSTRACT: In contrast to the NIR band, which is supported by an infrastructure of devices developed to serve telecommunication applications, the SWIR band remains out of reach for critical defense applications. While it is relatively simple to construct a low-noise oscillator within the… more
Abstract:Future NASA and commercial missions will increasingly target destinations with challenging topography and limited communication including unmapped asteroids, comets, and outer planet moons; surface rendezvous sites for sample return; and challenging sites like polar peaks, crater rims, and skylights… more
Abstract:Advances in computer-aided mission planning can enhance mission operations and science return for surface missions to Mars, the Moon, and beyond. While the innovations envisioned by this program are broadly applicable, they serve an immediate and urgent need for missions to prospect for volatiles at… more
Abstract:Ion channels are membrane proteins that allow the selective movement of charged molecules through cellular membranes. Many disease states, such as cystic fibrosis, muscular dystrophies, hypertension, and cardiac arrhythmias are caused by ion channel pathologies. Ion channels have been identified by… more
Abstract:DESCRIPTION (provided by applicant): Ion channels are membrane proteins that allow the selective movement of charged molecules through cellular membranes. Many disease states, such as cystic fibrosis, muscular dystrophies, hypertension, and cardiac arrhythmias are caused by ion channel pathologies.… more
Abstract:ABSTRACT: The semiconductor pumped fiber laser has generated considerable interest for High Energy Lasers (HELs) in a number of BMDS applications including long range sensing, communications and missile defense. The potential efficiency, compact size and low weight, reliability and ruggedness are… more
Abstract:DESCRIPTION (provided by applicant): Transmission electron microscopy is a valuable technique for characterizing biological therapeutics, vaccines, drug delivery vehicles, and nanoparticles. There is considerable evidence that links the physical propertiesof these samples to their bio-distribution,… more
Abstract:DESCRIPTION (provided by applicant): The principal goal of this SBIR Phase II proposal is to establish the clinical value of a novel prostate cancer (PCa) non-aggressiveness biomarker present in various physiological samples e.g. Prostatic Fluids, (PFs),Expressed Prostatic Secretions, (EPS), or… more
Abstract:Project Summary With an increasing older population, including the generational aging of the baby boomers , age-related eye diseases are common and becoming more prevalent. Currently, it is estimated that 11 million Americans suffer from age-related macular degeneration (AMD) - a number that is… more
Abstract:ABSTRACT: The modern warfighter requires freedom of action in space for friendly forces, and when necessary, the ability to defeat adversary efforts that interfere or attack US or allied space systems and to negate adversary space capabilities. Freedom of action in space is enabled by Space… more
Abstract:The objective of this effort is to develop and test a multi-sensor data fusion algorithm suite that will fuse information from multiple electro-optic (EO) and radio frequency (RF) sensors to estimate tracked objects physical properties and dynamics for the purpose of aiding in predicting signatures… more
Abstract:In order to counter emerging threats from the Middle East and Southeast Asia, the Ballistic Missile Defense System (BMDS) is acquiring new sensor (e.g. AN/TPY-2 and PTSS type) and weapon technology (SM-3). As these new technologies are fielded, the BMDS's Command, Control, Battle Management… more
Abstract:ABSTRACT: Orbit Logic and the University of Colorado propose a web-based Heimdall System to schedule observations of known objects and search for and establish custody of unknown objects from the Maui Space Surveillance Site. The Heimdall System includes a modeling environment and a scheduler… more
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