Abstract:DESCRIPTION (provided by applicant): Severe oxalate-related conditions such as primary hyperoxaluria (PH), secondary hyperoxaluria (SH) (as a result of short bowel syndrome, chronic inflammatory bowel disease, cystic fibrosis, post bariatric, and other malabsorption syndromes), Zellweger spectrum… more
Abstract:The overall goal of this Phase I SBIR application is to develop a non-cell-based means of inhibiting coagulation and platelet activation on engineered vascular grafts, so that small-diameter arterial grafts may be available off the shelf. This arterial graft will consist of human engineered tissue… more
Abstract:DESCRIPTION (provided by applicant): The goal of this Phase IIB SBIR application is to test the Sentien cellular bioreactor product (the Sentinel ) in a first-in-man study to assess safety and preliminary efficacy. Fifteen post-cardiac surgery patients that are diagnosed with acute kidney injury and… more
Abstract:DESCRIPTION (provided by applicant): Non-small cell lung cancer (NSCLC) is the most common lung cancer. Half of NSCLC shows WNT activation, marking poor survival. StemSynergy Therapeutics Inc (SSTI) has identified a family of WNT inhibitors based on a novel chemical scaffold, with our lead molecule… more
Abstract:The objective of the proposed work is to determine whether Dioxide Materials' miniature C02 sensors have the potential to be adapted for autonomous measurement of ocean carbon. The existing sensors have many advantages for measurements of ocean carbon. They are much smaller and less costly than… more
Abstract:ABSTRACT: The objective of this project is to move an energy efficient process for the conversion of carbon dioxide and water into syngas, a key feedstock for the production of synthetic chemicals. BENEFIT: If we are successful we will have a new process to convert air water and sunlight into… more
Abstract:Abstract Chronic pain occurs in a social context, frequently impacting couples in a committed relationship. Most couples have a reciprocal influence on one another. Partners of people with chronic pain are both affected by pain and may play a (positive ornegative) role in pain management. Depending… more
Abstract:DESCRIPTION (provided by applicant): Asthma is increasingly common and expensive. Current estimates place the number of people in the US with asthma at over 25M. Asthma accounts for one-quarter of all emergency room visits in the US. Direct treatment and indirect patient costs rose from 53B in 2002… more
Abstract:ABSTRACT: Tactical weapons have followed an evolutionary pattern of progressive capability that allows them to be ever more lethal against specific targets, but the resulting systems are highly optimized,"stove-piped"solutions to a very specific set of requirements. Modern warfare… more
Abstract:ABSTRACT: We propose to develop and demonstrate a rapid store trajectory analysis tool that uses pre-computed, highly-resolved Detached Eddy Simulation (DES) Computational Fluid Dynamics (CFD) data which has been compressed and stored in an easily reusable and distributable format. The tool will… more
Abstract:ABSTRACT: The thermal spray process has many inherent complexities within each sub-process including feedstock manufacturing, component surface preparation and masking, torch parameter selection, robot trajectory and laboratory coating evaluation. Each sub-process is governed by rigid… more
Abstract:ABSTRACT: ReliaCoat Technologies, LLC, in conjunction with program collaborators of Boeing Company and Sulzer Metco propose to develop an innovative engineered thermal spray coating solution for landing gear ID application. EHC coating replacement effort has led to HVOF WC-CoCr coating for landing… more
Abstract:NASA's future X-ray astronomy missions will require X-ray optics that have large effective areas, are lightweight, and cost effective. Recent X-ray telescopes, such as the Chandra Observatory, utilized reflectors made from zerodur which were up to 20mm thick. The thickness of these reflectors… more
Abstract:ABSTRACT: The purpose of the project is to develop and deliver an integrated cooling, heating, and power system that operates from multiple energy sources can be easily incorporated onto a building similar to a standard air conditioning system. The objective of the project is to build a prototype… more
Abstract:ABSTRACT: The objective of this sequential Phase II SBIR is to deliver a Technology Readiness Level 6 (TRL-6) airborne HF, VHF and UHF RF direction finding system that is suitable for integration with SUAS and to demonstrate it in a realistic airborne environment against representative signals. … more
Abstract:ABSTRACT: We propose to develop a compact and very capable micro airborne relay system which will will extend broadband communications range and provide the ability to transfer multiple HD video and data streams beyond the horizon. We can leverage technology we have previously developed which will… more
Abstract:The Office of Nuclear Energy, fuel cycle research and development program, requires improved radioisotope detectors for spent fuel rod monitoring and process control. Processing spent fuel rods releases large amounts of the fission by-product gas krypton-85 (Kr-85). This beta emitting radioisotope… more
Abstract:ABSTRACT: Identify approaches to increase spatial resolution of advanced emitter arrays. Provide an analysis of alternatives that evaluates the feasibility of each approach and identifies the best approach to pursue. Provide a system performance prediction for the chosen approach. BENEFIT: … more
Abstract:ABSTRACT: Current Air Force and industry radome designs are time- and resource-exhaustive, and require frequent maintenance and inspection throughout product lifecycle, due to outdated technologies. Typical panels are constructed with one of several joint types mated to the adjoining panel with… more
Abstract:Directed plasma discharge using Knite Inc."s Kinetic Spark Ignition (KSI) hardware is proposed as a means to quell augmentor screech tone. Contrary to typical plasma ignitors, where plasma discharge is between anode and cathode, the KSI can discharge plasma into the flow in a reproducible… more
Abstract:There is a need to further develop the internal combustion engine to increase its efficiency and reduce emissions. In this RFP, DoE has correctly concluded that presently utilized ignition technology is a limiting factor in further improvements. DoE has specified certain performance targets which it… more
Abstract:The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project is an environment resistant inertial measurement unit (eIMU) for commercial/industrial applications. This eIMU is a miniaturized navigation device that will enable enhanced GPS navigation down… more
Abstract:This Small Business Innovation Research Phase II project anticipates bringing forth a disruptive mouth guard technology that answers the urgent need for better dental protection. In the US alone, every year more than 1 million dental injuries occur, resulting in medical costs of roughly $500 million… more
Abstract:The Phase I objective of this SBIR was to develop a nanothermite-based ignition composition to improve the no-fire performance of electro-explosive devices (EEDs). The developed nanoparticulate aluminum/cupric oxide (nACO) ignition composition provided a significant improvement in no-fire… more
Abstract:For spacecraft design and development teams concerned with cost and schedule, the Quick Spacecraft Thermal Analysis Tool (QuickSTAT) is an innovative software suite that will significantly reduce labor costs and effort associated with the design, analysis, and optimization of spacecraft. Unlike… more
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