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Alanyl-glutamine as Oral Rehydration & Nutrition Therapy

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: N/A
Agency Tracking Number: 1R43DK058419-01A1
Amount: $100,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 2001
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
327 W MAIN ST
CHARLOTTESVILLE, VA 22902
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 RICHARD GUERRANT
 () -
Business Contact
Phone: (804) 971-6800
Email: DZISK@AOL.COM
Research Institution
N/A
Abstract

DESCRIPTION (Scanned from the Applicant's Abstract): This resubmission with
substantially sharpened goals and experimental design based on considerable new
preliminary data now fully addresses the reviewers' questions. Building on
promising preliminary data, we shall define the dose effects of
alanyl-glutamine relative to glutamine, glucose, and other glutamine
derivatives (including acetyl-glutamine) both in vitro and in vivo.
Specifically, in vitro studies will examine intestinal epithelial repair,
differentiation and prevention of apoptosis. In vivo studies will examine
cyclic AMP and cyclic GMP-mediated secretory diarrhea induced by the toxins of
V. cholerae and ST of E. coli, respectively, and the inflammatory, destructive
enteritis induced by C. difficile toxin A or cytotoxic chemotherapy. Our
overall goal for this first year is to have essential in vitro and in vivo data
to support pilot human studies of alanyl-glutamine's effectiveness. Success
will open commercial development of an effective new ORNT product for enhancing
intestinal repair and absorptive function that could have relevance across a
diverse range of human and animal applications.
PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

* Information listed above is at the time of submission. *

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