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ANALYSIS OF ICE NUCLEATION GENE PRODUCTS BY SITE-DIRECTED MUTAGENESIS

Award Information
Agency: National Science Foundation
Branch: N/A
Contract: N/A
Agency Tracking Number: 2596
Amount: $210,000.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 1987
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
6701 San Pablo Ave
Oakland, CA 94608
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Gareth Warren
 Dir Of Bacterial Genetics
 (415) 547-2315
Business Contact
Phone: () -
Research Institution
N/A
Abstract

AN ICE NUCLEATION GENE FROM PSEUDOMONAS SYRINGAE IS CLONED IN E. COLI AND ANALYSED BY DIRECTED MUTAGENESIS. PRECISE DUPLICATIONS AND DELETIONS OF REPETITIVE DOMAINS ARE GENERATED; NON-REPETITIVE DOMAINS ARE TARGETED FOR PARTIAL DELETION. THE RESULTING CONSTRUCTS ARE ANALYSED FOR THEIR EFFECTS ON THE TEMPERATURE SPECTRUM OF NUCLEATION FREQUENCY AND FOR THE ABILITY OF THEIR GENE PRODUCTS TO BE INCORPORATED INTO INNER AND OUTER CELL MEMBRANES. THE RESULTS WILL PROVIDE INFORMATION ON THE ASSEMBLY AND FUNCTION OF ICE NUCLEI IN VIVO. THIS WILL MAKE POSSIBLE THEGENETIC ENGINEERING OF ICE NUCLEI FOR REDUCED VARIABILITY, WHICH WILL IMPROVE THEIR SUITABILITY FOR COMMERCIAL USE.

* Information listed above is at the time of submission. *

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