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Automated Rational Design of Antibodies

Award Information
Agency: Department of Defense
Branch: Office for Chemical and Biological Defense
Contract: W911SR-04-P-0043
Agency Tracking Number: C041-105-0100
Amount: $67,765.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: CBD04-105
Solicitation Number: 2004.1
Solicitation Year: 2004
Award Year: 2004
Award Start Date (Proposal Award Date): 2004-05-17
Award End Date (Contract End Date): 2004-11-17
Small Business Information
100 Glenn Way, #1
San Carlos, CA 94070
United States
DUNS: 123955655
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Arvind Rajpal
 Principal Investigator
 (650) 654-5811
Business Contact
 Peter Matlock
Title: President
Phone: (650) 654-5811
Research Institution

Bioren's technology provides an efficient, automated, in vitro system to generate and optimize antibodies and antibody fragments through a rational, hypothesis-driven approach. Bioren's patented technology is based on synthetic oligonucleotide chemistry to create defined antibody mutations. Hypotheses regarding the impact of a specific amino acid's side-chain chemistry within the antigen binding pocket can then be explored in a systematic manner. Bioren's Look Through MutagenesisT (LTMT) and Walk Through MutagenesisT (WTMT) technologies enable targeted amino acids to be inserted in each individual position and in all possible combination of multiple positions in an antibody's CDR to create a compact and structured library. These technologies allow for the exploration of additive and co-operative consequences of substituting specific amino acids into multiple positions within the CDRs We will utilize Bioren's technology platform to improve the affinity of an existing anti- Botulinum neurotoxin type B (BoNT/B) antibody fragment. This higher affinity antibody fragment can be utilized to increased the sensitivity and selectivity of current detection and monitoring devices against the toxin.

* Information listed above is at the time of submission. *

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