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AUTOMATIC SUTURING AND LIGATING DEVICE

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: HL57064-01A1
Agency Tracking Number: 39358
Amount: $99,979.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 1997
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
12 SOUTH ST
Marblehead, MA 01945
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 EGAN, THOMAS D
 () -
Business Contact
Phone: (617) 631-2001
Research Institution
N/A
Abstract

AUTOMATIC SUTURING AND LIGATING DEVICE technology forms a completed stitch of absorbable or nonabsorbable polymer monofilament in second, even in areas of limited access such as laparoscopic surgery. Suture is threaded through tissue, tensioned, cut to length and welded in place using a proprietary process. This research seeks to demonstrate the feasibility of suturing using this device and method and establish its equivalency to knotted sutures. This will be accomplished by building a development prototype device, mechanical testing of sutures formed by the device to the requirements of USP XXIII and other standards, and a histological examination of the effects of the suturing process in both acute and chronic studies in an animal model. Proving equivalency to conventional sutures is a vital step toward development of a procedure-specific commercial product to be developed in Phase II. $ = TOTAL AWARD AMTS & NOT LIMITED TO PORTION OF PROJECT RELATED TO SUBJECT OF SEARCH SUBPROJECT $ = TOTAL AWARD AMOUNT DIVIDED BY NUMBER OF SUBPROJECTS SOURCE: CRISP FORMAT F FY 97 LAST UPDATE 04-07-98 1QUERY 1536 ID SEARCH 06/01/98 PAGE 413 --PROJECT NUMBER......1 R43 HL57070-01A1 INVESTIGATOR NAME/ADDRESS FY 97 MOLINA, LUIS IRG/INTRAMURAL UNIT..ZRG3 MOLICHEM-MAGELLAN AWARD AMOUNT......... $71,500 2135 N LAKESHORE DRIVE CHAPEL HILL, NC 27514 PERFORMING ORGANIZATION: MOLICHEM-MAGELLAN TITLE CLINICAL DEVELOPMENT OF DURAMYCIN FOR CYSTIC FIBROSIS ABSTRACT: DESCRIPTION: (adapted from applicant's abstract) Duramycin is a polycyclic peptide, which increases chloride transport and water mobilization when applied to the apical surface of the airway mucosa. Cystic fibrosis (CF) is a complex inherited disorder that affects children and young adults. Approximately 75,000 patients worldwide suffer from CF. In CF the mutated gene encodes a defective chloride channel. The resulting decreased chloride permeability reduces net water secretion increasing mucus viscosity in the lungs, where mucus plugs the airways and leads to infection. Drugs such as duramycin, targeted to chloride transport, are rational candidates for preventive therapy for CF. The purpose of this project is to test the ability of duramycin to induce chloride secretion in vivo, using potential difference measurements in the nose of normal and CF patients. $ = TOTAL AWARD AMTS & NOT LIMITED TO PORTION OF PROJECT RELATED TO SUBJECT OF SEARCH SUBPROJECT $ = TOTAL AWARD AMOUNT DIVIDED BY NUMBER OF SUBPROJECTS SOURCE: CRISP FORMAT F FY 97 LAST UPDATE 04-07-98 1QUERY 1536 ID SEARCH 06/01/98 PAGE 414 --PROJECT NUMBER......1 R43 HL57157-01A1 INVESTIGATOR NAME/ADDRESS FY 97 WALASZEK, ZBIGNIEW IRG/INTRAMURAL UNIT..ZRG2 BIOCHEMIX, INC AWARD AMOUNT......... $100,000 PO BOX 161391 AUSTIN, TX 78746 PERFORMING ORGANIZATION: BIOCHEMIX, INC. TITLE GLUCARATE REDUCTION OF SERUM CHOLESTEROL NO ABSTRACT ON FILE $ = TOTAL AWARD AMTS & NOT LIMITED TO PORTION OF PROJECT RELATED TO SUBJECT OF SEARCH SUBPROJECT $ = TOTAL AWARD AMOUNT DIVIDED BY NUMBER OF SUBPROJECTS SOURCE: CRISP FORMAT F FY 97 LAST UPDATE 04-07-98 1QUERY 1536 ID SEARCH 06/01/98 PAGE 415 --PROJECT NUMBER......1 R43 HL57186-01A1 INVESTIGATOR NAME/ADDRESS FY 97 MORAN, PATRICK T IRG/INTRAMURAL UNIT..ZRG4 ADVANCED MEDICAL DEVICES INC AWARD AMOUNT......... $99,845 152 WEST WISCONSIN AVE, STE 93 MILWAUKEE, WI 53203 PERFORMING ORGANIZATION: ADVANCED MEDICAL DEVICES, INC. TITLE TRANSTELEPHONIC MONITORING OF HYPERTENSION IN AFRICAN AMERICANS ABSTRACT: DESCRIPTION: (Adapted from Investigator's Abstract). In the era of decreasing resources for medical care it is likely that the quality of care, especially to the poor inner-city population, may suffer considerably. However, in appropriate instances using sophisticated computerized technology, we may be able to reduce the cost of care while improving quality of care. The purpose of this proposal is to determine the feasibility of long-term monitoring of poorly controlled hypertension in the inner-city African American population using a simple-to-operate transtelephonic physiologic monitoring system. We hypothesize that close monitoring of blood pressure and body weight in a routine daily basis will allow the care giver to reinforce therapy, improve drug compliance, assess efficacy of treatment, and provide patient education with regard to dietary and other deleterious habits. The goals of this investigation are to: (1) determine patients' ability to independently operate the home monitoring system; (2) determine patient compliance with a predefined monitoring schedule; (3) determine initial efficacy; (4) measure the cost to operate and maintain a service center which will be devoted to the monitoring and treatment of under-served patient population; and (5) determine the validity of Home Health Monitor data as compared with standard hospital instrumentation at the patient home. $ = TOTAL AWARD AMTS & NOT LIMITED TO PORTION OF PROJECT RELATED TO SUBJECT OF SEARCH SUBPROJECT $ = TOTAL AWARD AMOUNT DIVIDED BY NUMBER OF SUBPROJECTS SOURCE: CRISP FORMAT F FY 97 LAST UPDATE 04-07-98 1QUERY 1536 ID SEARCH 06/01/98 PAGE 416 --PROJECT NUMBER......1 R43 HL57690-01 INVESTIGATOR NAME/ADDRESS FY 97 JEWELL, JACK L IRG/INTRAMURAL UNIT..ZRG3 PICOLIGHT INCORPORATED AWARD AMOUNT......... $99,939 4622 SUNSHINE CANYON DR BOULDER, CO 80302 PERFORMING ORGANIZATION: PICOLIGHT, INC. TITLE ON-AIRWAY--IDEAL SPECTROSCOPIC SENSOR FOR CARBON DIOXIDE ABSTRACT: This Small Business Innovation Research Phase I project begins development of the ideal on-airway carbon dioxide respiratory sensor: a spectroscopic sensor based on vertical-cavity surface-emitting lasers (VCSELs). The proposed sensor is sensitive, low cost, fast, small, lightweight, low power, eye-safe, reliable, and requires no consumables. Spectroscopic sensors based on laser diodes are becoming the sensor of choice due to the qualities listed above. VCSELs have superior spectroscopic and beam qualities over other laser diodes, and are becoming far less expensive than existing lasers. Key to the program is development of VCSELs at the about 1.6 micron wavelength used for carbon dioxide sensing. The VCSEL development and eventual component cost will be greatly leveraged by development of VCSELs at similar wavelengths for optical fiber communications. A about 1.6 micron VCSEL will be produced in Phase I using novel materials. Its wavelength, spectrum, and tuning characteristics will be verified in a setup using carbon dioxide gas. The phase II program will produce a sensor nearly ready for use in hospitals. The sensor will also be ideal for monitoring carbon monoxide in homes and industry.

* Information listed above is at the time of submission. *

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