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Biodegradable Antibiotic Beads for Osteomyletis

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1 R43 AR43539-01,
Agency Tracking Number: 29175
Amount: $79,941.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 1995
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
21-C Olympia Avenue
Woburn, MA 01801
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Elie Nuwayser
 () -
Business Contact
Phone: () -
Research Institution
N/A
Abstract

Deep infection following open fractures or bone surgery are a challenging orthopedic problem. The ugentamicin-impregnated PMMA cement or beads has become a successful part of the management of osteomchronic post-fracture infections, but these materials have disadvantages, such as the need for a secthe PMMA, the existence of many gentamicin-immune organisms, and highly non-uniform delivery. The obprogram is to develop improved anti-osteomyelitic beads based on biodegradable polymers, better anticontrolling coating. The proposed 3 to 6 mm beads will employ two antibiotics in a porous polylactidcore surrounded by a rate-controlling PLG coating. The beads are intended to deliver a minimum inhibantibiotic for 60 days and to disappear within 60-90 days. The proposal describes methods of bead prcharacterization for a six month Phase I program. Phase II will optimize the formulation, conduct instudy stability, and prepare and submit an IND.

* Information listed above is at the time of submission. *

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