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Biomaterials for Orbit Reconstruction

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: PHS2001-2
Agency Tracking Number: 1R41EY013524-01
Amount: $99,984.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 2001
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
177 BOVET RD, STE 600 SAN MATEO, CA 94402
SAN MATEO, CA 94402
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 RAJENDRA BHATNAGAR
 (650) 638-2353
 THAPLI@AOL.COM
Business Contact
 BHATNAGAR, MARY E
Phone: (415) 341-1126
Email: MEB@BIOMIMESYS.COM
Research Institution
 UNIVERSITY OF CALIFORNIA
 
UNIVERSITY OF CALIFORNIA
SAN FRANCISCO, CA 97584
United States

 Nonprofit College or University
Abstract

DESCRIPTION (Verbatim from Applicant): We will develop biomimetic materials for
repair and orthoplasty of the orbit and surrounding bony structures. These
scaffolds will incorporate a cell binding peptide related to collagen which
will allow them to serve as collagen-like anchorages for cells. These Collagen
Surrogate Matrices (CSM) will facilitate haptotactic migration of cells from
host tissue, promote 3-D colony formation, and they will provide a permissive
environment for cell differentiation and tissue remodeling. In Phase I studies,
we will (1) examine quantitatively the adhesion, migration, and colonization of
CSM by osteoblast-like cell lines, (2) characterize the morphology of cellular
colonies using histological and electron microscopic procedures, (3) determine
the effect of various growth factors on the attachment, proliferation, and
differentiation of cells on synthetic scaffolds, and (4) examine the expression
of bone-specific molecules (type I collagen, alkaline phosphatase, osteonectin,
osteocalcin), and growth factors (TGF-B1, BMPs 2, 4, 6 and 7) using PCR. In
Phase II we will examine the performance of these matrices as grafts in animal
models as space fillers in tissues. CSM will be also useful for tissue
augmentation and tissue engineering.
PROPOSED COMMERCIAL APPLICATIONS:
There is a major need for biomaterials for repair of the bony orbit and surrounding cranio-facial skeletal structures. Such materials can also be useful for repair of bone elsewhere. The overall market value of biomaterials for orthopedic grafts and implants is estimated to be in billions of dollars.

* Information listed above is at the time of submission. *

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