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Biotechnology and Biomaterials

Description:

Emphasis is on the development of novel biomaterials and technologies for promoting repair, regeneration, restoration and reconstruction of diseased and injured oral and craniofacial tissues. This includes development of natural and synthetic biomaterials for dental repair and for manufacturing of craniofacial tissue replacement constructs, quantitative methods for evaluating the quality and performance of biomaterials and tissue constructs, as well as their interactions with host tissues. Specific examples of relevant small business applications could include but are not limited to:

A. Develop technologies for design and fabrication of biocompatible biomaterials and tissue constructs to be used for reconstruction and regeneration of oral and craniofacial tissues.

B. Develop non-destructive in vitro and in vivo methods for imaging of cells, tissue constructs and biomaterials.

C. Develop methods for curtailing disease-associated inflammation and promoting wound healing and endogenous regeneration of oral and craniofacial tissues.

D. Develop synthetic analogues of oral and craniofacial tissues and organs for use in high throughput biological assays of tissue function and physiology.

E. Develop sensitive methods for measuring and quantification of biomaterial-tissue biocompatibility and biotoxicity including restorative materials interacting with secondary decay.

F. Develop mathematical and computer algorithms for modeling oral and craniofacial tissue function and physiology.

G. Develop technologies for ensuring sterility of biomaterials and tissue engineered constructs prior to implantation.

H. Develop efficient and non-immunogenic viral and non-viral gene delivery systems to oral and craniofacial tissues.

I. Develop nanotechnology-based implantable biomaterials for dental, oral and craniofacial tissue restoration.

J. Develop improved surgical techniques for replacement of dental, oral and craniofacial tissues and organs.

K. Develop safe and effective technologies for the diagnosis and treatment of temporomandibular joint disorders (TMJDs).

L. Develop safe and effective biomaterials and construct fabrication technologies for repairing TMJDs.

M. Develop new or improved composite biomaterials and adhesive sealants (possibly replacing Bis-GMA resin-based systems) suitable for restoring crowns of posterior teeth and exposed roots of teeth.

N. Develop new effective orthodontic and other prosthetic appliances and constructs.

O. Develop approaches for generating complex tissue/organ structures, such as teeth, periodontal ligament, TMJ, and vascularized and innervated bone and muscle.

P. Develop methods for standardization and comparison of different stem and progenitor cell populations for use in dental and craniofacial tissue engineering.

Q. Develop methods for targeted delivery and release of therapeutic biomolecules to oral and craniofacial tissues.

R. Development of instrumentation for early caries detection and comparison studies on specificity and selectivity with respect to current clinical practice.

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