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Channel to Droplet Sample Extraction and Purification Using Electrowetting Device

Award Information
Agency: Department of Homeland Security
Branch: N/A
Contract: NBCHC050123
Agency Tracking Number: 0511198
Amount: $99,929.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: H-SB05.1-001
Solicitation Number: N/A
Timeline
Solicitation Year: 2005
Award Year: 2005
Award Start Date (Proposal Award Date): 2005-05-31
Award End Date (Contract End Date): N/A
Small Business Information
1100 Glendon Avenue 17th Floor
Los Angeles, CA 90024
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Uichong Yi
 (310) 689-7316
 uyi@coremicrosolutions.com
Business Contact
 Wayne Liu
Phone: (310) 689-7316
Email: wliu@coremicrosolutions.com
Research Institution
N/A
Abstract

To develop advanced ¿channel-to-droplet¿ sample extraction and purification functions on a compact cartridge that is free of sensitive and complex microfluidic components, Core Microsolutions (CMSS) and Professor Sung Cho of the University of Pittsburgh propose to integrate Electrowetting-on-Dielectric (EWOD) droplet handling and in-droplet concentration capabilities with well proven channel-based separation methods to: a) separate target particles, b) extract the concentrated target particles in a mobile droplet, c) bifurcate the particle mix within the droplet using Dielectrophoretic separation methods for a 2nd level of concentration effects, and then d) drive the target-rich droplet to a sensing point or pipette extraction site. This proposed DHS work will develop the sample extraction and purification methods needed to complement CMSS¿ ongoing two year $1M NIH Biodefense Phase I grant that will produce the hardware and driving systems needed for novel bacteria immuno-capture and transduction on an EWOD sensing cartridge. This hybridization of channel and droplet-based sample handling on a generic slide cartridge will enable elegant transfer of channel-based separation products to an array of electronic, optical, surface plasmon resonance (SPR), mass spectrometry (MS) instrumentation. Comparisons in cost/performance will be made against existing methods at the end of Phase I.

* Information listed above is at the time of submission. *

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