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Compliance Measurements for Diagnosis of Atherosclerosis

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1 R43 HL54363-01,
Agency Tracking Number: 29532
Amount: $100,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Solicitation Year: N/A
Award Year: 1995
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
Box 381593, Harvard Square
Cambridge, MA 02238
United States
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Michael Curley
 () -
Business Contact
Phone: () -
Research Institution

This project will result in a catheter and associated instrumentation that will use measurements ofof coronary arteries caused by atherosclerotic lesions to diagnose and characterize those lesions. Tinserted into the coronary arteries to a location proximal to the lesion. It will generate low-press1 and 50 kHz to diagnose the lesion. The change in the compliance or distensibility, of the vessel nwill cause some of the pulses energy to be reflected back toward the catheter. The catheter will meawhich will indicate the character, the fractional blockage and the length of the lesion. All measureproximal to the lesion, so measurements can be made regardless of the fractional blockage caused bycompliance is most sensitive to the character of the lesion (soft vs. calcified), and by the residuafractional blockage), and so this catheter will be a unique tool, capable of complete characterizatisingle measurement. It will be useful for guiding the choice of angioplasty or atherectomy therapy,assessing the effectiveness of the therapy used.

* Information listed above is at the time of submission. *

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