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Cytokines And Cytokine Assays For Swine

Award Information
Agency: Department of Agriculture
Branch: N/A
Contract: N/A
Agency Tracking Number: 37710
Amount: $48,995.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Solicitation Year: N/A
Award Year: 1997
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
30 Commerce Way
Woburn, MA 01801
United States
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
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Business Contact
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Research Institution

Cytokines play a key role in the immunobiology of swine, and have the potential to improve themanagement of these animals. The pattern and tissue distribution of inflammatory cytokine expressionmay be indicative of the health or infectious status of the animal. Thus, the development of rapidcytokine tests is necessary to exploit this useful diagnostic information.Cytokines may also play another important role in protecting swine health; they are reported to beuseful as a vaccine adjuvants in animals. The availability of purified biologically active cytokines isessential to elucidate the roles of these cytokines in the initiation and maintenance of immune responseand to develop a source of these proteins for vaccination studies.With the exception of recombinant porcine Tumor Necrosis Factor alpha (TNF?) and an immunoassayfor porcine TNF? (both developed and marketed by Endogen, Inc.), there are no commerciallyavailable porcine cytokine reagents.In Phase 1, Endogen proposes to express, purify and characterize recombinant porcine Interleukin 1beta (IL-1¿), Interleukin 6 (IL-6), Interleukin 8 (IL-8), Interleukin 12 (IL-12), and Interferon Gamma(IFN?). These recombinant cytokines will then be used to achieve the Phase II goals; the developmentof a panel of cytokine immunoassays for swine health monitoring, and the investigation of recombinantcytokines as vaccine adjuvants.

* Information listed above is at the time of submission. *

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