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Development of Artificial, Collagen Based Corneal Grafts

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1 R43 EY10485-1,
Agency Tracking Number: 25070
Amount: $72,044.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Solicitation Year: N/A
Award Year: 1994
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
125 Nagog Park
Acton, MA 01720
United States
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Dale Devore
 (508) 263-6992
Business Contact
Phone: () -
Research Institution

The objective is to develop an artificial full-thickness corneal graft to replace damaged corneain millions of people who suffer from blindness due to damaged or diseased cornea. The specific aimsof Phase I are to fabricate prototype grafts composed of a clear, soluble collagen core surrounded by aperipheral ring, or skirt, containing' intact collagen fibers embedded in soluble collagen. Preliminaryevaluations in the rabbit model have demonstrated biocompatibility, rapid healing of the host-graftjunction, variable re-epithelialization, and reasonable optical stability. However, additional developmentis needed to improve and demonstrate optical and biological stability of the optic core, provide consistentreepithelialization of the entire graft, and show long-term biocompatibility in animal models. Results fromPhase I will lead to more extensive and longer-term evaluations in animal models. These results will benecessary for submitting appropriate applications to FDA to initiate phased, human clinical trials.

* Information listed above is at the time of submission. *

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