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High-throughput Direct Structural Screening for Drug Lead Compounds

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-06-C-0399
Agency Tracking Number: A064-032-0056
Amount: $99,946.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: A06-T032
Solicitation Number: N/A
Solicitation Year: 2006
Award Year: 2006
Award Start Date (Proposal Award Date): 2006-08-18
Award End Date (Contract End Date): 2007-08-17
Small Business Information
3333 N. Torrey Pines Ct.
La Jolla, CA 92037
United States
DUNS: 926035262
HUBZone Owned: No
Woman Owned: Yes
Socially and Economically Disadvantaged: No
Principal Investigator
 Gary Fogel
 (858) 455-6449
Business Contact
 David Fogel
Title: Chief Executive Officer
Phone: (858) 455-6449
Research Institution
 Gaea Armour
900 Otay Lakes Road
Chula Vista, CA 91910
United States

 (619) 482-6563
 Domestic Nonprofit Research Organization

The Army has an obvious and immediate need for greater exploration of small molecules in the search for novel anti-malarial drugs. The innovative techniques offered in this proposal utilize methods of iterated automated fragment assembly coupled with an intelligent compound screening tool to facilitate scientific advancement. The resulting computational methods can increase the rate and exploration of small molecule space for novel malaria inhibitors. The proposed Phase I research makes use of docking algorithms as prototyping methods for these computational approaches with DHFR as the target of interest. Docking methods will be expanded to include NMR research in Phase II. The Phase I research and development sets the stage for continued Phase II research and development and transition for field use. The technology’s applications go beyond Army needs to all branches of the military, and also commercial and academic drug discovery pipelines. The prospect for commercialization for the resulting technology in the bioinformatics sector is high in light of the increased need for rapid small molecule search strategies.

* Information listed above is at the time of submission. *

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