You are here

IDENTIFICATION AND EXPRESSION OF INSECTICIDE TARGETS

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41AI051791-01
Agency Tracking Number: AI051791
Amount: $106,597.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 2002
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
CAMBRIA BIOSCIENCES, LLC 8A HENSHAW ST
WOBURN, MA 01801
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 SCOTT CHOUINARD
 (781) 275-2800
 SCHOUINARD@CAMBRIABIO.COM
Business Contact
 SUSAN BATTITE
Phone: (781) 938-1333
Email: SBATTITE@CAMBRIABIO.COM
Research Institution
 UNIVERSITY OF CONNECTICUT HEALTH CENTER
 
UCT
FARMINGTON, CT 06030
United States

 Nonprofit College or University
Abstract

DESCRIPTION (Provided by applicant): Insect-borne infectious diseases such as
malaria affect at least 1 billion people worldwide, and over 1.5 million of
these infected individuals die each year. Malarial parasites and many other
vector-borne pathogens have developed resistance to current drugs, and vaccines
are not available or feasible for many of these pathogens. Insect vector
control programs have historically been an effective strategy for reducing
disease transmission. However, some of these diseases have remained intractable
while others are experiencing a resurgence. The long-term goal of this project
is to identify new safe, selective, and effective insecticides that can be
incorporated into an integrated approach for insect vector management. This
project will exploit naturally occurring insect-specific pesticidal compounds
isolated from the venom of the Australian funnel-web spider Hadronyche versuta.
Individual peptide toxins will be used as probes to identify genetically
validated insecticide targets that can be moved into an insecticide discovery
program. The specific aims for phase I of this project are; A) to continue the
functional analysis of three toxins exhibiting a high degree of insect
selectivity; B) perform genetic screens with transgenic Drosophila melanogaster
lines carrying peptide toxin-encoding genes to identify genetic loci conferring
target-site resistance to transgenically-expressed toxins; C) establish stably
transformed insect cell lines expressing target genes for use in phase II
chemical screens. This multidisciplinary approach will identify genetically
validated pesticide targets, which will form the basis of a novel
high-throughput screen for safe and selective insecticides in the phase II and
III stages of this study.

* Information listed above is at the time of submission. *

US Flag An Official Website of the United States Government