IMPROVED SYNTHESIS OF RADIORECEPTOR LIGANDS

THIS RESEARCH WILL EXPAND UPON PRELIMINARY STUDIES THAT DEMONSTRATED THE FEASIBILITY OF A SOLID-PHASE, FLOW-THROUGH DEVICE TO CARRY OUT CATALYTIC HYDROGEN TRANSFER REACTIONS. THESE STUDIES USED PALLADIUM-COATED GLASS FIBER FILTERS AS WELL AS SILICA/POLYVINYLCHLORIDE MEMBRANE. PHASE I RESEARCH WILL EVALUATE OTHER SUPPORTS, FOR EXAMPLE, CONTROLLED PORE GLASS AND SILICA/POLYETHYLENE MEMBRANES, AS MATRICES FOR THIS PROCEDURE. IN ADDITION, A THIOL SCAVENGER SUPPORT WILL BE PREPARED AND TESTED AS A DEVICE TOREDUCE OR ELIMINATE CATALYST POISONING. STUDIES WILL ALSO BE CARRIED OUT TO DETERMINE IF NICKEL DEPOSITED ON THESE MATRICES WILL SUPPORT CATALYSIS IN THE SAME WAY AS THE PALLADIUM-COATED SUPPORTS. THE UTILITY OF ISOPROPANOL AS A HYDROGEN DONOR IN CATALYTIC HYDROGEN TRANSFER REACTIONS WILLALSO BE STUDIED. BASED ON THE ABOVE, A DEVICE AND PROTOCOL WILL BE DEVELOPED THAT CAN CATALYZE DEHALOHYDROGENATION REACTIONS WITH THE ULTIMATE GOAL BEING DEVELOPMENT OF A FACILE METHOD FOR THE PREPARATION OF ISOTOPICALLY LABELED LIGANDS FOR USE IN A VARIETY OF BIOMEDICAL/BIOCHEMICAL APPLICATIONS.