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Metabolomic Evaluation of Combat Personnel for Optimum Fitness and Performance

Award Information
Agency: Department of Defense
Branch: Army
Contract: W911SR-04-P-0096
Agency Tracking Number: A045-020-0042
Amount: $100,000.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: A04-T020
Solicitation Number: N/A
Solicitation Year: 2004
Award Year: 2004
Award Start Date (Proposal Award Date): 2004-09-21
Award End Date (Contract End Date): 2005-09-21
Small Business Information
2545 Boatman Avenue
West Sacramento, CA 95691
United States
DUNS: 111558156
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Steven Watkins
 (916) 371-7974
Business Contact
 Thomas Anderson
Title: Chief Executive Officer
Phone: (916) 371-7974
Research Institution
 University of California
 Louise Ivey
Office of VC/Research, 1 Shields Avenue
Davis, CA 95631
United States

 (530) 752-7076
 Nonprofit College or University

This Phase I proposal for evaluation of combat personnel for optimum fitness and performance will be based on measuring lipid and amino acid biomarkers prior to and during the performance of ultra-marathon participants. Plasma or serum samples will be collected before individuals participate in the marathon and at various times during the race. The specific aims are to analyze and profile structural changes in plasma metabolites that may indicate tissue or metabolic changes and to seek evidence of physiological stress during strenuous physical activity by measurement of eicosanoids, which are produced by macrophages and that can indicate possible compromise to the immune system. This study will be related to the research topic by developing analytical tools to identify biomarkers of physical readiness, and markers that will be predictive of potential stress damage and damage that occurs in individual soldiers during times of physical stress. Based on plasma metabolite profiles, Phase II research would seek nutritional means to optimize soldier physiological performance under stress in the field.

* Information listed above is at the time of submission. *

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