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Miniature Elctrohydraulic Total Artificial Heart

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1 R43 HL53887-01,
Agency Tracking Number: 29523
Amount: $100,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Solicitation Year: N/A
Award Year: 1995
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
24 Cherry Hill Drive
Danvers, MA 01923
United States
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Farhad Zarinetchi
 () -
Business Contact
Phone: () -
Research Institution

The limited availability of donor hearts for people with end stage heart failure has driven the condevelopment of mechanical circulatory support systems (MCSSs). MCSSs can be broadly classified intocontinuous flow systems. Pulsatile systems drive blood indirectly through blood pumps, resulting inThis disadvantage of these systems, however, is their relatively large size. Continuous flow systemssimplicity, but with a flow driver that directly contracts blood, resulting in increased tendency tohemolysis. The MCSSs described here can potentially combine the blood compatibility of pulsatile MCSthe simplicity and small size of continuous MCSSs. This device modifies our existing electrohydrauliinformation intentionally deleted] The device operates as a simpler, low stroke volume and high beatdeliver up to 12 L/min against a 100 mmHg afterload, and has the potential to be 1/2 the size of exiPhase I studies will focus on complete in vitro characterization of the device, incorporation of Staand preliminary in vivo evaluation. Phase II studies will focus on miniaturization and further in viincluding studies of nonpulsatile versus pulsatile circulatory support.

* Information listed above is at the time of submission. *

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